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Il3ra interleukin 3 receptor, alpha chain [ Mus musculus (house mouse) ]

Gene ID: 16188, updated on 21-Apr-2024

Summary

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Official Symbol
Il3raprovided by MGI
Official Full Name
interleukin 3 receptor, alpha chainprovided by MGI
Primary source
MGI:MGI:96553
See related
Ensembl:ENSMUSG00000068758 AllianceGenome:MGI:96553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD123; SUT-1; CDw123
Summary
Enables interleukin-3 binding activity and interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Located in membrane. Is expressed in several structures, including cardiovascular system mesenchyme; dorsal aorta; early conceptus; genitourinary system; and umbilical or vitelline vessel. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 13.7), testis adult (RPKM 11.5) and 26 other tissues See more
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Genomic context

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Location:
14 A1; 14 7.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (8114270..8123851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14345912..14355493)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 35 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5422 Neighboring gene olfactory receptor family 2 subfamily T member 1 Neighboring gene STARR-seq mESC enhancer starr_35990 Neighboring gene STARR-seq mESC enhancer starr_35989 Neighboring gene predicted gene 3895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3. Baumeister T, et al. J Invest Dermatol, 2003 Aug. PMID 12880419
  2. Genetic basis of hypo-responsiveness of A/J mice to interleukin-3. Leslie KB, et al. Blood, 1996 Apr 15. PMID 8605333
  3. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. Ichihara M, et al. EMBO J, 1995 Mar 1. PMID 7889941, Free PMC Article
  4. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Hara T, et al. Blood, 1995 May 1. PMID 7727767
  5. [Effect of total saponins from Sanguisorba officinalis on megakaryocyte progenitor cells proliferation, differentiation and relative receptor expression]. Dai YP, et al. Zhongguo Zhong Yao Za Zhi, 2014 May. PMID 25095385

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.
    Title: EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.
  2. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha.
    Title: MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
  3. High IL3RA expression is associated with breast cancer.
    Title: IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway.
  4. expression of the interleukin 3 receptor alpha (Il3ra also known as Cd123) subunit is dependent on Jmjd2/Kdm4 through a mechanism involving removal of H3K9me3 from the promoter of the Il3ra gene.
    Title: Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.
  5. Data indicate that the proliferative and differentiative effect of saponins from Sanguisorba officinalis (DYS) on megakaryocyte progenitor cells is correlated to the up-regulation of IL-3 receptor and c-kit expression.
    Title: [Effect of total saponins from Sanguisorba officinalis on megakaryocyte progenitor cells proliferation, differentiation and relative receptor expression].
  6. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor.
    Title: SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
  7. Interleukin-3/dendritic cells expressed higher levels of interleukin-3 receptor.
    Title: Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-3 receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within interleukin-3-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-3-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-3 receptor subunit alpha
Names
IL-3 receptor alpha chain
IL-3 receptor subunit alpha
IL-3R subunit alpha
IL-3R-alpha
IL-3RA
Il-3 alpha subunit
interleukin-3 receptor class II alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418423.1 → NP_001405352.1  interleukin-3 receptor subunit alpha isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  2. NM_001418424.1 → NP_001405353.1  interleukin-3 receptor subunit alpha isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  3. NM_001418425.1 → NP_001405354.1  interleukin-3 receptor subunit alpha isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  4. NM_001418427.1 → NP_001405356.1  interleukin-3 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  5. NM_001418428.1 → NP_001405357.1  interleukin-3 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  6. NM_001418429.1 → NP_001405358.1  interleukin-3 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  7. NM_001418436.1 → NP_001405365.1  interleukin-3 receptor subunit alpha isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689
    UniProtKB/Swiss-Prot
    B9VI80, P26952

  8. NM_001418437.1 → NP_001405366.1  interleukin-3 receptor subunit alpha isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689
    UniProtKB/Swiss-Prot
    B9VI80, P26952
    Related
    ENSMUSP00000153358.2, ENSMUST00000224163.2

  9. NM_001418440.1 → NP_001405369.1  interleukin-3 receptor subunit alpha isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  10. NM_001418442.1 → NP_001405371.1  interleukin-3 receptor subunit alpha isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  11. NM_001418443.1 → NP_001405372.1  interleukin-3 receptor subunit alpha isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  12. NM_001418445.1 → NP_001405374.1  interleukin-3 receptor subunit alpha isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  13. NM_001418447.1 → NP_001405376.1  interleukin-3 receptor subunit alpha isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  14. NM_001418449.1 → NP_001405378.1  interleukin-3 receptor subunit alpha isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  15. NM_001418450.1 → NP_001405379.1  interleukin-3 receptor subunit alpha isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  16. NM_001418451.1 → NP_001405380.1  interleukin-3 receptor subunit alpha isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  17. NM_001418452.1 → NP_001405381.1  interleukin-3 receptor subunit alpha isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689
    Related
    ENSMUSP00000153086.2, ENSMUST00000224877.2

  18. NM_001418453.1 → NP_001405382.1  interleukin-3 receptor subunit alpha isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  19. NM_001418454.1 → NP_001405383.1  interleukin-3 receptor subunit alpha isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  20. NM_001418455.1 → NP_001405384.1  interleukin-3 receptor subunit alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT025689

  21. NM_001418456.1 → NP_001405385.1  interleukin-3 receptor subunit alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT025689

  22. NM_001418457.1 → NP_001405386.1  interleukin-3 receptor subunit alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT025689

  23. NM_001418458.1 → NP_001405387.1  interleukin-3 receptor subunit alpha isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  24. NM_001418459.1 → NP_001405388.1  interleukin-3 receptor subunit alpha isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    CT025689

  25. NM_001418460.1 → NP_001405389.1  interleukin-3 receptor subunit alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT025689

  26. NM_001418461.1 → NP_001405390.1  interleukin-3 receptor subunit alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT025689

  27. NM_001418462.1 → NP_001405391.1  interleukin-3 receptor subunit alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    CT025689

  28. NM_008369.2 → NP_032395.1  interleukin-3 receptor subunit alpha isoform 3 precursor

    See identical proteins and their annotated locations for NP_032395.1

    Status: VALIDATED

    Source sequence(s)
    CT025689
    Consensus CDS
    CCDS26827.1
    UniProtKB/Swiss-Prot
    B9VI80, P26952
    Related
    ENSMUSP00000088079.3, ENSMUST00000090591.4
    Conserved Domains (1) summary
    pfam09240
    Location:120 → 233
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    8114270..8123851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247655.1 → XP_030103515.1  interleukin-3 receptor subunit alpha isoform X15

    Conserved Domains (1) summary
    pfam09240
    Location:113 → 223
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  2. XM_017315868.1 → XP_017171357.1  interleukin-3 receptor subunit alpha isoform X18

    Conserved Domains (2) summary
    pfam18611
    Location:149 → 209
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    cl21522
    Location:237 → 272
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_017315866.1 → XP_017171355.1  interleukin-3 receptor subunit alpha isoform X11

    Conserved Domains (2) summary
    pfam18611
    Location:149 → 209
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
    cl21522
    Location:237 → 272
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_036158476.1 → XP_036014369.1  interleukin-3 receptor subunit alpha isoform X10

    Conserved Domains (1) summary
    cl21522
    Location:237 → 272
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_017315865.3 → XP_017171354.1  interleukin-3 receptor subunit alpha isoform X9

    Conserved Domains (2) summary
    pfam09240
    Location:237 → 347
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:149 → 209
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  6. XM_017315864.3 → XP_017171353.1  interleukin-3 receptor subunit alpha isoform X7

    Conserved Domains (2) summary
    pfam09240
    Location:237 → 347
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:149 → 209
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  7. XM_036158475.1 → XP_036014368.1  interleukin-3 receptor subunit alpha isoform X5

    Conserved Domains (1) summary
    pfam09240
    Location:237 → 347
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  8. XM_017315867.3 → XP_017171356.1  interleukin-3 receptor subunit alpha isoform X16

    Conserved Domains (2) summary
    pfam09240
    Location:237 → 347
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:149 → 209
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  9. XM_036158477.1 → XP_036014370.1  interleukin-3 receptor subunit alpha isoform X13

    Conserved Domains (1) summary
    pfam09240
    Location:170 → 280
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  10. XM_036158478.1 → XP_036014371.1  interleukin-3 receptor subunit alpha isoform X19

    Conserved Domains (1) summary
    cl21522
    Location:113 → 148
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  11. XM_006517946.3 → XP_006518009.1  interleukin-3 receptor subunit alpha isoform X21

    Conserved Domains (1) summary
    cl21522
    Location:8 → 85
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  12. XM_036158479.1 → XP_036014372.1  interleukin-3 receptor subunit alpha isoform X20

  13. XM_030247656.1 → XP_030103516.1  interleukin-3 receptor subunit alpha isoform X17

    Conserved Domains (1) summary
    pfam09240
    Location:108 → 218
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

  14. XM_006517940.2 → XP_006518003.1  interleukin-3 receptor subunit alpha isoform X12

    Conserved Domains (2) summary
    pfam09240
    Location:119 → 229
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:31 → 91
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  15. XM_006517942.4 → XP_006518005.1  interleukin-3 receptor subunit alpha isoform X15

    See identical proteins and their annotated locations for XP_006518005.1

    Conserved Domains (1) summary
    pfam09240
    Location:113 → 223
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26952.1 GenPept UniProtKB/Swiss-Prot:P26952

Gene LinkOut

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