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FSIP1 fibrous sheath interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 161835, updated on 5-Mar-2024

Summary

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Official Symbol
FSIP1provided by HGNC
Official Full Name
fibrous sheath interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:21674
See related
Ensembl:ENSG00000150667 MIM:615795; AllianceGenome:HGNC:21674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD10
Expression
Biased expression in appendix (RPKM 7.4), bone marrow (RPKM 3.4) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
15q14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (39597440..39782841, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37402151..37588039, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (39892232..40075042, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:39872371-39873108 Neighboring gene uncharacterized LOC124903470 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39885600-39886799 Neighboring gene THBS1 intronic transcript 1 Neighboring gene thrombospondin 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39909535-39910734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9216 Neighboring gene uncharacterized LOC105370785 Neighboring gene NANOG hESC enhancer GRCh37_chr15:39958804-39959320 Neighboring gene Sharpr-MPRA regulatory region 4200 Neighboring gene uncharacterized LOC105370941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6312 Neighboring gene G protein-coupled receptor 176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176182-40176852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176853-40177522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40177802-40178334 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40178335-40178866 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:40179399-40179929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40186807-40187332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40200676-40201176 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40209802-40209908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40211506-40212311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer. Yan X, et al. Dis Markers, 2022. PMID 35692888, Free PMC Article
  2. Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma. Chen M, et al. Gene, 2020 Oct 30. PMID 32717308
  3. FSIP1 is correlated with estrogen receptor status and poor prognosis. Li X, et al. Mol Carcinog, 2020 Jan. PMID 31713931
  4. Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization. Yan M, et al. Cell Death Dis, 2019 Feb 27. PMID 30814489, Free PMC Article
  5. Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients. Mao Y, et al. Oncotarget, 2017 Feb 14. PMID 28086239, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
    Title: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway.
  2. FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer.
    Title: FSIP1 Is Associated with Poor Prognosis and Can Be Used to Construct a Prognostic Model in Gastric Cancer.
  3. Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.
    Title: Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.
  4. FSIP1 bound to the multidrug resistance protein 1 (MRP1) and stabilized it, and knocking out FSIP1 decreased MRP1 expression and increased cellular docetaxel accumulation. In sum, FSIP1 promotes breast carcinogenesis and mediates docetaxel resistance.
    Title: Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization.
  5. FSIP1 overexpression correlated with decreased overall survival in hormone receptor-positive breast cancer patients.
    Title: FSIP1 is correlated with estrogen receptor status and poor prognosis.
  6. High FSIP1 expression is associated with drug resistance in triple-negative breast cancer.
    Title: FSIP1 regulates autophagy in breast cancer.
  7. FSIP1 binds HER2 directly, which regulates breast cancer growth and invasiveness
    Title: FSIP1 binds HER2 directly to regulate breast cancer growth and invasiveness.
  8. Results suggest that evaluating fibrous sheath interacting protein 1 (FSIP1) status in addition to TNM stage during routine pathological examinations could improve prognostic predictions in non-small cell lung cancer (NSCLC) patients.
    Title: Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients.
  9. FSIP1 may play an important role in the tumorigenesis and invasion of breast cancer and is a potential biomarker for breast cancer diagnosis or prognosis.
    Title: Expression and clinicopathological significance of FSIP1 in breast cancer.
  10. prevalence and uniformity of FSIP1 expression in breast tumors
    Title: Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that FSIP1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with FSIP1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35989

General protein information

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Preferred Names
fibrous sheath-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324338.2 → NP_001311267.1  fibrous sheath-interacting protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC023908, AC037198
    Consensus CDS
    CCDS10050.1
    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03
    Conserved Domains (1) summary
    pfam15554
    Location:2 → 394
    FSIP1; FSIP1 family

  2. NM_152597.5 → NP_689810.3  fibrous sheath-interacting protein 1

    See identical proteins and their annotated locations for NP_689810.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC023908, AC037198, AK093308, BX642685
    Consensus CDS
    CCDS10050.1
    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03
    Related
    ENSP00000280236.3, ENST00000350221.4
    Conserved Domains (1) summary
    pfam15554
    Location:2 → 394
    FSIP1; FSIP1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    39597440..39782841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521305.4 → XP_011519607.1  fibrous sheath-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011519607.1

    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03
    Conserved Domains (1) summary
    pfam15554
    Location:2 → 394
    FSIP1; FSIP1 family

  2. XM_011521306.3 → XP_011519608.1  fibrous sheath-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011519608.1

    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03
    Conserved Domains (1) summary
    pfam15554
    Location:2 → 394
    FSIP1; FSIP1 family

  3. XM_011521311.4 → XP_011519613.1  fibrous sheath-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam15554
    Location:1 → 184
    FSIP1; FSIP1 family

  4. XM_017021972.3 → XP_016877461.1  fibrous sheath-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam15554
    Location:1 → 184
    FSIP1; FSIP1 family

  5. XM_011521309.4 → XP_011519611.1  fibrous sheath-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    NF033479
    Location:5 → 296
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  6. XM_047432212.1 → XP_047288168.1  fibrous sheath-interacting protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    37402151..37588039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377408.1 → XP_054233383.1  fibrous sheath-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03

  2. XM_054377409.1 → XP_054233384.1  fibrous sheath-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6X2C8, Q86Y89, Q8NA03

  3. XM_054377412.1 → XP_054233387.1  fibrous sheath-interacting protein 1 isoform X4

  4. XM_054377413.1 → XP_054233388.1  fibrous sheath-interacting protein 1 isoform X4

  5. XM_054377411.1 → XP_054233386.1  fibrous sheath-interacting protein 1 isoform X3

  6. XM_054377410.1 → XP_054233385.1  fibrous sheath-interacting protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NA03.1 GenPept UniProtKB/Swiss-Prot:Q8NA03

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