Il1rap interleukin 1 receptor accessory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1rapprovided by MGI
Official Full Name: interleukin 1 receptor accessory proteinprovided by MGI
Primary source: MGI:MGI:104975
See related: Ensembl:ENSMUSG00000022514 AllianceGenome:MGI:104975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-1RAcP; 6430709H04Rik
Summary: Enables interleukin-1 receptor activity; interleukin-33 receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of dendrite development; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is expressed in dorsal aorta; future brain; genitourinary system; liver; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 5.5), cortex adult (RPKM 2.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 18.21 cM; 16 B2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (26400259..26548878)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (26581509..26730128)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.
Title: IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.
These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1/IL-1RAcP.
Title: Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation.
We conclude that neuron-specific AcPb plays a critical role in host defenses and sleep homeostasis.
Title: The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge in mice.
In experimental biliary atresia, miR-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 and Il1RAP are down-regulated by miR-29.
Title: MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia.
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.
Title: Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.
Title: A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.
these observations establish AcP as co-receptor for IL-33 signaling via ST2 and suggest a novel role for sAcP in modulating the biological activity of IL-33
Title: The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.
IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family
Title: IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells.
IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex.
Title: IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.
data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI
Title: Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI255955 (e-PCR)
- UniSTS:160549

NoName (e-PCR)
- UniSTS:224828

RH133894 (e-PCR)
- UniSTS:217177

Il1rap (e-PCR), detects polymorphism
- UniSTS:525670

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-1 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-33 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-33-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-33-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by trans-synaptic complex	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling by trans-synaptic complex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: interleukin-1 receptor accessory protein

Names: IL-1 receptor accessory protein; interleukin-33 receptot beta chain

NP_001152789.1

EC 3.2.2.6

NP_001152790.1

EC 3.2.2.6

NP_032390.1

EC 3.2.2.6

NP_598864.1

EC 3.2.2.6

XP_036015684.1

EC 3.2.2.6

XP_036015685.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159317.1 → NP_001152789.1 interleukin-1 receptor accessory protein isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the C-terminus compared to isoform d.

Source sequence(s)

AK034269, AK083209, BU526001

Consensus CDS

CCDS49814.1

UniProtKB/TrEMBL

E9Q6I2, Q3V2X3

Related

ENSMUSP00000128100.3, ENSMUST00000166294.9

Conserved Domains (5) summary

smart00255
Location:404 → 547

TIR; Toll - interleukin 1 - resistance

cd00096
Location:156 → 160

Ig; Ig strand B [structural motif]

cd20931
Location:243 → 349

Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)

cd20992
Location:25 → 132

Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:145 → 235

Ig; Immunoglobulin domain
NM_001159318.1 → NP_001152790.1 interleukin-1 receptor accessory protein isoform d precursor

See identical proteins and their annotated locations for NP_001152790.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (d).

Source sequence(s)

AK034269, AK083209, AK136782, BU526001

Consensus CDS

CCDS49815.1

UniProtKB/TrEMBL

Q3V2X3

Related

ENSMUSP00000093843.3, ENSMUST00000096129.9

Conserved Domains (5) summary

smart00255
Location:404 → 547

TIR; Toll - interleukin 1 - resistance

cd00096
Location:145 → 150

Ig; Ig strand A [structural motif]

cd20931
Location:243 → 349

Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)

cd20992
Location:25 → 132

Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:145 → 235

Ig; Immunoglobulin domain
NM_008364.2 → NP_032390.1 interleukin-1 receptor accessory protein isoform a precursor

See identical proteins and their annotated locations for NP_032390.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus compared to isoform d.

Source sequence(s)

AC154234, AK045686, BU526001

Consensus CDS

CCDS28089.1

UniProtKB/Swiss-Prot

Q3UVZ1, Q61730, Q8VCB9

Related

ENSMUSP00000023156.7, ENSMUST00000023156.13

Conserved Domains (4) summary

cd00096
Location:262 → 346

Ig; Immunoglobulin domain

PHA02785
Location:3 → 325

PHA02785; IL-beta-binding protein; Provisional

pfam01582
Location:405 → 546

TIR; TIR domain

cl11960
Location:26 → 131

Ig; Immunoglobulin domain
NM_134103.2 → NP_598864.1 interleukin-1 receptor accessory protein isoform b precursor

See identical proteins and their annotated locations for NP_598864.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform d.

Source sequence(s)

AK039582, AK149467, BU526001

Consensus CDS

CCDS57023.1

UniProtKB/TrEMBL

G3UY13, Q3UEL3

Related

ENSMUSP00000134202.2, ENSMUST00000174202.8

Conserved Domains (3) summary

cd00096
Location:262 → 346

Ig; Immunoglobulin domain

PHA02785
Location:3 → 325

PHA02785; IL-beta-binding protein; Provisional

cl11960
Location:26 → 131

Ig; Immunoglobulin domain

RNA

NR_152416.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC154234, AC154601, CT009561

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

26400259..26548878

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159791.1 → XP_036015684.1 interleukin-1 receptor accessory protein isoform X1

UniProtKB/TrEMBL

Q3V2X3

Conserved Domains (5) summary

smart00255
Location:404 → 547

TIR; Toll - interleukin 1 - resistance

cd00096
Location:145 → 150

Ig; Ig strand A [structural motif]

cd20931
Location:243 → 349

Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)

cd20992
Location:25 → 132

Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:145 → 235

Ig; Immunoglobulin domain
XM_036159792.1 → XP_036015685.1 interleukin-1 receptor accessory protein isoform X1

UniProtKB/TrEMBL

Q3V2X3

Conserved Domains (5) summary

smart00255
Location:404 → 547

TIR; Toll - interleukin 1 - resistance

cd00096
Location:145 → 150

Ig; Ig strand A [structural motif]

cd20931
Location:243 → 349

Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)

cd20992
Location:25 → 132

Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:145 → 235

Ig; Immunoglobulin domain