Irak1 interleukin-1 receptor-associated kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irak1provided by MGI
Official Full Name: interleukin-1 receptor-associated kinase 1provided by MGI
Primary source: MGI:MGI:107420
See related: Ensembl:ENSMUSG00000031392 AllianceGenome:MGI:107420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S
Summary: Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of bacterial origin; and toll-like receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 73.0), ovary adult (RPKM 47.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.61 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73057520..73067527, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74013914..74023921, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Title: The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Title: Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.
Title: IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.
Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Title: Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Title: Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
Title: Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.
Title: IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling.
Title: MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling.
Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.
Title: Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.
Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout.
Title: Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125824 (e-PCR)
- UniSTS:162569

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH131080 (e-PCR)
- UniSTS:214363

REN88550 (e-PCR)
- UniSTS:413348

REN88551 (e-PCR)
- UniSTS:413349

Il1rak (e-PCR), detects polymorphism
- UniSTS:143546

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-1-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-33-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to peptidoglycan	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 2 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor 2 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase 1

Names: interleukin-1 receptor-associated kinase-1b; pelle-like protein kinase

NP_001171444.1

EC 2.7.11.1

NP_001171445.1

EC 2.7.11.1

NP_001171446.1

EC 2.7.11.1

NP_001171447.1

EC 2.7.11.1

NP_032389.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177973.1 → NP_001171444.1 interleukin-1 receptor-associated kinase 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AK143694, AL672002

Consensus CDS

CCDS53105.1

UniProtKB/TrEMBL

B1AUW6, Q99J34

Related

ENSMUSP00000033769.9, ENSMUST00000033769.15

Conserved Domains (3) summary

smart00221
Location:219 → 514

STYKc; Protein kinase; unclassified specificity

cd08794
Location:17 → 100

Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1

cl21453
Location:219 → 514

PKc_like; Protein Kinases, catalytic domain
NM_001177974.1 → NP_001171445.1 interleukin-1 receptor-associated kinase 1 isoform 4

See identical proteins and their annotated locations for NP_001171445.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).

Source sequence(s)

AL672002, BP760087, U56773

Consensus CDS

CCDS30219.2

UniProtKB/Swiss-Prot

B1AUW4, Q62406, Q6Y3Z5, Q6Y3Z6

UniProtKB/TrEMBL

B1AUW9, Q540G0

Related

ENSMUSP00000064448.6, ENSMUST00000068286.12

Conserved Domains (3) summary

smart00221
Location:218 → 518

STYKc; Protein kinase; unclassified specificity

cd08794
Location:17 → 100

Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1

cl21453
Location:218 → 521

PKc_like; Protein Kinases, catalytic domain
NM_001177975.1 → NP_001171446.1 interleukin-1 receptor-associated kinase 1 isoform 3

See identical proteins and their annotated locations for NP_001171446.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK143694, AL672002, BY729815

Consensus CDS

CCDS53104.1

UniProtKB/TrEMBL

B1AUW9, Q8BR10

Related

ENSMUSP00000109994.4, ENSMUST00000114354.10

Conserved Domains (3) summary

smart00221
Location:219 → 519

STYKc; Protein kinase; unclassified specificity

cd08794
Location:17 → 100

Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1

cl21453
Location:219 → 522

PKc_like; Protein Kinases, catalytic domain
NM_001177976.1 → NP_001171447.1 interleukin-1 receptor-associated kinase 1 isoform 2

See identical proteins and their annotated locations for NP_001171447.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AL672002, BP760087, U56773

Consensus CDS

CCDS53103.1

UniProtKB/TrEMBL

B1AUW9

Related

ENSMUSP00000110000.4, ENSMUST00000114360.10

Conserved Domains (3) summary

smart00221
Location:218 → 518

STYKc; Protein kinase; unclassified specificity

cd08794
Location:17 → 100

Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1

cl21453
Location:218 → 521

PKc_like; Protein Kinases, catalytic domain
NM_008363.2 → NP_032389.2 interleukin-1 receptor-associated kinase 1 isoform 4

See identical proteins and their annotated locations for NP_032389.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).

Source sequence(s)

AF103876, AL672002

Consensus CDS

CCDS30219.2

UniProtKB/Swiss-Prot

B1AUW4, Q62406, Q6Y3Z5, Q6Y3Z6

UniProtKB/TrEMBL

B1AUW9, Q540G0

Related

ENSMUSP00000109992.2, ENSMUST00000114352.8

Conserved Domains (3) summary

smart00221
Location:218 → 518

STYKc; Protein kinase; unclassified specificity

cd08794
Location:17 → 100

Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1

cl21453
Location:218 → 521

PKc_like; Protein Kinases, catalytic domain