Il16 interleukin 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il16provided by MGI
Official Full Name: interleukin 16provided by MGI
Primary source: MGI:MGI:1270855
See related: Ensembl:ENSMUSG00000001741 AllianceGenome:MGI:1270855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4048
Summary: Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 26.8), spleen adult (RPKM 17.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 47.43 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83292027..83395479, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (83642819..83746028, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro.
Title: Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro.
Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
Title: Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
In the pristane model of IFN-driven pulmonary inflammation and hemorrhage, miR-125a levels are decreased in the lung as early as 3 days after pristane administration; this is accompanied by an increase in neutrophil recruitment and IL-16 expression. Alterations in miR-125a levels in the lung result in enhanced expression of the proinflammatory cytokine IL-16 which acts directly on lung epithelial cells.
Title: IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation.
IL-16 enhanced lung allergic inflammatory response may be associated with the up-regulation of IgE and the promotion of Th2 and Th17 cytokine production.
Title: Interleukin-16 aggravates ovalbumin-induced allergic inflammation by enhancing Th2 and Th17 cytokine production in a mouse model.
Repetitive Exposure of IL-17 Into the Murine Air Pouch Favors the Recruitment of Inflammatory Monocytes and the Release of IL-16 and TREM-1 in the Inflammatory Fluids.
Title: Repetitive Exposure of IL-17 Into the Murine Air Pouch Favors the Recruitment of Inflammatory Monocytes and the Release of IL-16 and TREM-1 in the Inflammatory Fluids.
The production of IL-16 contributed to lung damage as neutralization of IL-16 enhanced S. aureus clearance and resulted in diminished lung pathology in S. aureus pneumonia.
Title: Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia.
Data indicate that knockdown of translocator protein TSPO by siRNAhad showed no effect on the productions of TNF-alpha, IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells.
Title: [Down-regulation of TSPO expression doesn't affect the productions of TNF-α, IL-1β and IL-6 in LPS-stimulated BV-2 microglia].
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
Title: Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
Data show overexpression of pro-IL-16 impaired resting B cell proliferation mediated through regulating nuclear factor (NF)-kappaB activation, and siRNA knock-down of pro-IL-16 expression decreased the level of p27(kip) and increased the level of Skp2.
Title: Pro-IL-16 is associated with MHC class II-mediated negative regulation of mouse resting B cell activation through MAP kinases, NF-κB and Skp2-dependent p27kip regulation.
CD4-positive T cells are specifically recruited to the lung in a dendritic cell-independent but IL-16-dependent process and diminish neutrophil recruitment through increased IL-10 production.
Title: Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit261 (e-PCR), detects polymorphism
- UniSTS:131157

AF017111 (e-PCR)
- UniSTS:159662

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-interleukin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360087.1 → NP_001347016.1 pro-interleukin-16 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC116389, AC158576

Conserved Domains (2) summary

cd00992
Location:1206 → 1283

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl26464
Location:620 → 931

Atrophin-1; Atrophin-1 family
NM_001360088.1 → NP_001347017.1 pro-interleukin-16 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC116389, AC158576

UniProtKB/TrEMBL

Q3UZ81

Conserved Domains (2) summary

cd00992
Location:517 → 594

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl27975
Location:53 → 367

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
NM_001360089.1 → NP_001347018.1 pro-interleukin-16 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC158576, AK038319

Consensus CDS

CCDS90266.1

UniProtKB/TrEMBL

Q3UZ81

Related

ENSMUSP00000146496.2, ENSMUST00000145610.8

Conserved Domains (2) summary

cd00992
Location:406 → 483

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl26464
Location:61 → 268

Atrophin-1; Atrophin-1 family
NM_010551.4 → NP_034681.2 pro-interleukin-16 isoform 2

See identical proteins and their annotated locations for NP_034681.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC116389, AC158576

Consensus CDS

CCDS21412.1

UniProtKB/Swiss-Prot

O54824, O70236, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6

Related

ENSMUSP00000001792.5, ENSMUST00000001792.12

Conserved Domains (2) summary

PHA03247
Location:518 → 829

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1104 → 1181

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

83292027..83395479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507385.4 → XP_006507448.1 pro-interleukin-16 isoform X1

Conserved Domains (2) summary

PHA03247
Location:565 → 876

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1151 → 1228

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011241680.3 → XP_011239982.1 pro-interleukin-16 isoform X2

Conserved Domains (2) summary

PHA03247
Location:557 → 868

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1143 → 1220

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011241681.3 → XP_011239983.1 pro-interleukin-16 isoform X3

See identical proteins and their annotated locations for XP_011239983.1

UniProtKB/Swiss-Prot

O54824, O70236, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6

Conserved Domains (2) summary

PHA03247
Location:518 → 829

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1104 → 1181

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006507386.5 → XP_006507449.1 pro-interleukin-16 isoform X3

See identical proteins and their annotated locations for XP_006507449.1

UniProtKB/Swiss-Prot

O54824, O70236, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6

Conserved Domains (2) summary

PHA03247
Location:518 → 829

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:1104 → 1181

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...