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Igfbp2 insulin-like growth factor binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 16008, updated on 23-Mar-2024

Summary

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Official Symbol
Igfbp2provided by MGI
Official Full Name
insulin-like growth factor binding protein 2provided by MGI
Primary source
MGI:MGI:96437
See related
Ensembl:ENSMUSG00000039323 AllianceGenome:MGI:96437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IBP-2; Igfbp-2; mIGFBP-2
Summary
The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in bladder adult (RPKM 311.4), liver E18 (RPKM 285.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Igfbp2 in Genome Data Viewer
Location:
1 C3; 1 36.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72863650..72891633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72824480..72852474)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51632 Neighboring gene predicted gene, 39663 Neighboring gene predicted gene, 30788 Neighboring gene predicted gene, 30847 Neighboring gene STARR-seq mESC enhancer starr_01288 Neighboring gene STARR-seq mESC enhancer starr_01290 Neighboring gene insulin-like growth factor binding protein 5 Neighboring gene STARR-seq mESC enhancer starr_01295 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration. Lin YH, et al. Cell Stem Cell, 2023 May 4. PMID 37146585,
  2. FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation. Wang J, et al. FASEB J, 2023 Apr. PMID 36934380
  3. Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy. Harris BT, et al. Surg Endosc, 2022 Sep. PMID 35226161
  4. Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice. Xi G, et al. Endocrinology, 2020 Apr 1. PMID 32168373, Free PMC Article
  5. IGFBP2 Plays an Essential Role in Cognitive Development during Early Life. Khan S, et al. Adv Sci (Weinh), 2019 Dec. PMID 31832311, Free PMC Article

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
    Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
  2. Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
    Title: Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
  3. FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
    Title: FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
  4. Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
    Title: Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
  5. Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
    Title: Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
  6. Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
    Title: Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
  7. Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
    Title: Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
  8. Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
    Title: Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
  9. An integrative systems approach identifies IGFBP-2, Mfap4, and Spp1 as novel candidates in Marfan syndrome-related pathophysiology.
    Title: An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.
  10. Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages.
    Title: IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
insulin-like growth factor-binding protein 2
Names
IGF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310659.2 → NP_001297588.1  insulin-like growth factor-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115870, AC121498
    Consensus CDS
    CCDS78613.1
    UniProtKB/TrEMBL
    D3YU40
    Related
    ENSMUSP00000112706.2, ENSMUST00000120564.2
    Conserved Domains (1) summary
    pfam00086
    Location:60 → 139
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  2. NM_001420245.1 → NP_001407174.1  insulin-like growth factor-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115870, AC121498
    UniProtKB/TrEMBL
    D3YU40

  3. NM_008342.4 → NP_032368.2  insulin-like growth factor-binding protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032368.2

    Status: VALIDATED

    Source sequence(s)
    AC115870, AC121498
    Consensus CDS
    CCDS15036.1
    UniProtKB/Swiss-Prot
    P47877, Q61722, Q91VK7
    UniProtKB/TrEMBL
    Q9D057
    Related
    ENSMUSP00000046610.5, ENSMUST00000047328.11
    Conserved Domains (2) summary
    smart00121
    Location:38 → 116
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:207 → 286
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72863650..72891633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250357.2 → XP_030106217.1  insulin-like growth factor-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    D3YU40
    Conserved Domains (1) summary
    pfam00086
    Location:60 → 139
    Thyroglobulin_1; Thyroglobulin type-1 repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47877.2 GenPept UniProtKB/Swiss-Prot:P47877

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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