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Igfals insulin-like growth factor binding protein, acid labile subunit [ Mus musculus (house mouse) ]

Gene ID: 16005, updated on 21-Apr-2024

Summary

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Official Symbol
Igfalsprovided by MGI
Official Full Name
insulin-like growth factor binding protein, acid labile subunitprovided by MGI
Primary source
MGI:MGI:107973
See related
Ensembl:ENSMUSG00000046070 AllianceGenome:MGI:107973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALS; Albs
Summary
Predicted to enable Roundabout binding activity; heparin binding activity; and insulin-like growth factor binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Is expressed in ductus deferens; epididymis; and testis. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 141.0), subcutaneous fat pad adult (RPKM 33.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25096818..25100985)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24877844..24882011)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene meiosis specific with OB domains Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Liu Z, et al. Endocrinology, 2017 Aug 1. PMID 28475811, Free PMC Article
  2. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Kennedy OD, et al. Endocrinology, 2014 Mar. PMID 24424061, Free PMC Article
  3. The acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolism. Ueki I, et al. Endocrinology, 2009 Jul. PMID 19299456, Free PMC Article
  4. Overexpression of the acid-labile subunit of the IGF ternary complex in transgenic mice. Silha JV, et al. Endocrinology, 2001 Oct. PMID 11564688
  5. Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse. Boisclair YR, et al. Pediatr Nephrol, 2000 Jul. PMID 10912519

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Igfals gene has a role in skeletal response of male mice to anabolic hormone therapy
    Title: Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.
  2. A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed
    Title: Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA4111, MGC150140, MGC150141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
insulin-like growth factor-binding protein complex acid labile subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364895.1 → NP_001351824.1  insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/Swiss-Prot
    P70389, Q9DBI7
    UniProtKB/TrEMBL
    Q791Q5
    Conserved Domains (4) summary
    smart00013
    Location:40 → 78
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:124 → 147
    LRR_RI; leucine-rich repeat [structural motif]
    cl15307
    Location:535 → 578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl26793
    Location:61 → 523
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  2. NM_001364896.1 → NP_001351825.1  insulin-like growth factor-binding protein complex acid labile subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    Q570Z9
    Conserved Domains (4) summary
    smart00013
    Location:75 → 113
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:159 → 182
    LRR_RI; leucine-rich repeat [structural motif]
    cl15307
    Location:570 → 613
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl26793
    Location:96 → 558
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  3. NM_008340.4 → NP_032366.2  insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor

    See identical proteins and their annotated locations for NP_032366.2

    Status: VALIDATED

    Source sequence(s)
    AC166102, AK004926, BP768883
    Consensus CDS
    CCDS37497.1
    UniProtKB/Swiss-Prot
    P70389, Q9DBI7
    UniProtKB/TrEMBL
    A0A0R4J0S2, Q791Q5
    Related
    ENSMUSP00000060169.7, ENSMUST00000050714.8
    Conserved Domains (5) summary
    smart00013
    Location:40 → 78
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:277 → 537
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:124 → 147
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:219 → 278
    LRR_8; Leucine rich repeat
    cl15307
    Location:535 → 578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25096818..25100985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70389.1 GenPept UniProtKB/Swiss-Prot:P70389

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