Igf2 insulin-like growth factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2provided by MGI
Official Full Name: insulin-like growth factor 2provided by MGI
Primary source: MGI:MGI:96434
See related: Ensembl:ENSMUSG00000048583 AllianceGenome:MGI:96434
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mpr; M6pr; Peg2; Igf-2; Igf-II
Summary: This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression: Biased expression in limb E14.5 (RPKM 601.7), liver E18 (RPKM 468.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142204505..142220566, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142650768..142666816, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal activity drives IGF2 expression from pericytes to form long-term memory.
Title: Neuronal activity drives IGF2 expression from pericytes to form long-term memory.
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression.
Title: IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression.
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice.
Title: IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice.
TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation.
Title: TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation.
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition.
Title: Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition.
Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.
Title: Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.
Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.
Title: Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.
Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia.
Title: Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia.
Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease.
Title: Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease.
IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
Title: IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (201)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igf2 (e-PCR), detects polymorphism
- UniSTS:526084

Igf2 (e-PCR), detects polymorphism
- UniSTS:471311

D7Mit46 (e-PCR), detects polymorphism
- UniSTS:116751

Igf2 (e-PCR), detects polymorphism
- UniSTS:531477

Igf2 (e-PCR), detects polymorphism
- UniSTS:532252

Igf2 (e-PCR), detects polymorphism
- UniSTS:470558

Igf2 (e-PCR), detects polymorphism
- UniSTS:238123

PMC151856P1 (e-PCR)
- UniSTS:271187

Igf2 (e-PCR), detects polymorphism
- UniSTS:516448

AW742446 (e-PCR)
- UniSTS:208229

Igf2 (e-PCR), detects polymorphism
- UniSTS:143471

Igf2 (e-PCR), detects polymorphism
- UniSTS:143472

Igf2 (e-PCR), detects polymorphism
- UniSTS:143473

Igf2 (e-PCR), detects polymorphism
- UniSTS:143474

Igf2 (e-PCR), detects polymorphism
- UniSTS:143475

Igf2 (e-PCR), detects polymorphism
- UniSTS:143476

Igf2 (e-PCR), detects polymorphism
- UniSTS:506996

Igf2 (e-PCR), detects polymorphism
- UniSTS:143477

Igf2 (e-PCR), detects polymorphism
- UniSTS:143478

Igf2 (e-PCR), detects polymorphism
- UniSTS:143479

Igf2 (e-PCR), detects polymorphism
- UniSTS:143480

Igf2 (e-PCR), detects polymorphism
- UniSTS:143481

Igf2 (e-PCR), detects polymorphism
- UniSTS:143482

PMC316622P2 (e-PCR)
- UniSTS:273021

ECD21742 (e-PCR)
- UniSTS:302735

NoName (e-PCR)
- UniSTS:532138

Igf2 (e-PCR), detects polymorphism
- UniSTS:532138

NoName (e-PCR)
- UniSTS:532139

Igf2 (e-PCR), detects polymorphism
- UniSTS:532139

UniSTS:276141 (e-PCR)
- UniSTS:276141

Igf2 (e-PCR), detects polymorphism
- UniSTS:276141

Igf2 (e-PCR), detects polymorphism
- UniSTS:516548

Igf2 (e-PCR), detects polymorphism
- UniSTS:502726

PMC309645P4 (e-PCR)
- UniSTS:272603

PMC309645P5 (e-PCR)
- UniSTS:272604

PMC309645P6 (e-PCR)
- UniSTS:272605

IGF2 (e-PCR)
- UniSTS:253673

Igf2 (e-PCR), detects polymorphism
- UniSTS:465394

Igf2 (e-PCR), detects polymorphism
- UniSTS:516604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IGI Inferred from Genetic Interaction more info	PubMed
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic placenta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in spongiotrophoblast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor II

Names: multiplication-stimulating polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122736.2 → NP_001116208.1 insulin-like growth factor II isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001116208.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.

Source sequence(s)

AC013548, BC058615, CN527329

Consensus CDS

CCDS52458.1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Related

ENSMUSP00000101556.2, ENSMUST00000105936.8

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_001122737.2 → NP_001116209.1 insulin-like growth factor II isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001116209.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC013548, BC058615

Consensus CDS

CCDS52458.1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Related

ENSMUSP00000000033.6, ENSMUST00000000033.12

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_001315488.1 → NP_001302417.1 insulin-like growth factor II isoform 2 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC013548, CN666734

Consensus CDS

CCDS52458.1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Related

ENSMUSP00000101555.2, ENSMUST00000105935.8

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_001315489.1 → NP_001302418.1 insulin-like growth factor II isoform 2 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate exon at its 5' terminus, lacks a portion of the 3' UTR and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AC013548, BC053489

Consensus CDS

CCDS52458.1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_010514.3 → NP_034644.2 insulin-like growth factor II isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC013548, CF742200

Consensus CDS

CCDS22033.2

UniProtKB/Swiss-Prot

P09535

Related

ENSMUSP00000114076.2, ENSMUST00000121128.8

Conserved Domains (2) summary

cd04368
Location:39 → 102

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:123 → 177

IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

142204505..142220566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152697.1 → XP_036008590.1 insulin-like growth factor II isoform X1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
XM_006508487.1 → XP_006508550.1 insulin-like growth factor II isoform X1

See identical proteins and their annotated locations for XP_006508550.1

UniProtKB/Swiss-Prot

E9QLW5, P09535

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
XM_030242159.1 → XP_030098019.1 insulin-like growth factor II isoform X2

Conserved Domains (1) summary

cd04368
Location:39 → 102

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...