SLC35G1 solute carrier family 35 member G1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC35G1provided by HGNC
Official Full Name: solute carrier family 35 member G1provided by HGNC
Primary source: HGNC:HGNC:26607
See related: Ensembl:ENSG00000176273 MIM:617167; AllianceGenome:HGNC:26607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: POST; TMEM20; C10orf60
Summary: This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]
Expression: Biased expression in duodenum (RPKM 26.1), small intestine (RPKM 12.8) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (93893978..93909830)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (94773053..94788891)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (95653735..95669587)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
Title: Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis.
Title: Nuclear export of ubiquitinated proteins via the UBIN-POST system.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH104340 (e-PCR)
- UniSTS:98665

NoName (e-PCR)
- UniSTS:483743

WI-14114 (e-PCR)
- UniSTS:76470

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 35 member G1

Names: partner of STIM1; transmembrane protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051626.1 RefSeqGene

Range

5009..14855

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001134658.3 → NP_001128130.1 solute carrier family 35 member G1 isoform 1

See identical proteins and their annotated locations for NP_001128130.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK091309, AL138923, BC041432, BC104814

Consensus CDS

CCDS44459.1

UniProtKB/Swiss-Prot

Q2M3R5, Q86YG5, Q8NBA5

UniProtKB/TrEMBL

B7ZKP1

Related

ENSP00000400932.1, ENST00000427197.2

Conserved Domains (1) summary

COG0697
Location:70 → 359

RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
NM_001345993.2 → NP_001332922.1 solute carrier family 35 member G1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AL138923, BC143283, DA644843

UniProtKB/TrEMBL

B7ZKP0

Conserved Domains (1) summary

COG0697
Location:53 → 342

RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
NM_153226.4 → NP_694958.1 solute carrier family 35 member G1 isoform 2

See identical proteins and their annotated locations for NP_694958.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a protein (isoform 2) that is one amino acid shorter than isoform 1.

Source sequence(s)

AK091309, AL138923, BC041432

Consensus CDS

CCDS7432.1

UniProtKB/TrEMBL

B7ZKP1

Related

ENSP00000360462.3, ENST00000371408.7

Conserved Domains (2) summary

COG0697
Location:69 → 358

RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

pfam00892
Location:68 → 201

EamA; EamA-like transporter family

RNA

NR_144335.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AL138923, BC036382, DA644843

Related

ENST00000483386.5
NR_144336.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK091309, AL138923, BC047102, BM677569, BU608007, R56424

Related

ENST00000603665.1
NR_144337.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AL138923