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Idh1 isocitrate dehydrogenase 1 (NADP+), soluble [ Mus musculus (house mouse) ]

Gene ID: 15926, updated on 5-Mar-2024

Summary

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Official Symbol
Idh1provided by MGI
Official Full Name
isocitrate dehydrogenase 1 (NADP+), solubleprovided by MGI
Primary source
MGI:MGI:96413
See related
Ensembl:ENSMUSG00000025950 AllianceGenome:MGI:96413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Id-1; Idpc; Idh-1; E030024J03Rik
Summary
Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Idh1 in Genome Data Viewer
Location:
1 C2- C3; 1 32.91 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65197775..65225638, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65158616..65186479, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630023F18 gene Neighboring gene STARR-seq mESC enhancer starr_01174 Neighboring gene crystallin, gamma A Neighboring gene STARR-seq mESC enhancer starr_01175 Neighboring gene predicted gene, 36358 Neighboring gene STARR-seq mESC enhancer starr_01176 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65224921-65225030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65225772-65225881 Neighboring gene STARR-positive B cell enhancer ABC_E5765 Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene STARR-positive B cell enhancer ABC_E5766 Neighboring gene STARR-seq mESC enhancer starr_01177 Neighboring gene parathyroid hormone 2 receptor Neighboring gene STARR-seq mESC enhancer starr_01178 Neighboring gene STARR-seq mESC enhancer starr_01179

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutant IDH1 attenuates hepatic lipogenesis through PTEN dependent pathway. Zhao Q. Biochem Biophys Res Commun, 2022 Dec 31. PMID 36410274
  2. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Dow J, et al. Mol Cancer Res, 2021 Dec. PMID 34535560, Free PMC Article
  3. IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis. Gu Y, et al. Blood, 2021 Feb 18. PMID 33254233
  4. Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma. Yang R, et al. Oncogene, 2020 Oct. PMID 32855525
  5. Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E. Zhang Y, et al. Cancer Res, 2019 Oct 1. PMID 31391185, Free PMC Article

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
    Title: Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
  2. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
    Title: IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
  3. Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
    Title: Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
  4. Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
    Title: Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
  5. HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
    Title: HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
  6. Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
    Title: Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
  7. Mutant IDH Inhibits IFNgamma-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
    Title: Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
  8. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
    Title: Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
  9. Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/alpha-KG-mediated glycolysis.
    Title: Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
  10. Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
    Title: Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115782

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isocitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of phospholipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isocitrate dehydrogenase [NADP] cytoplasmic
Names
IDH
IDP
NADP(+)-specific ICDH
cytosolic NADP-isocitrate dehydrogenase
oxalosuccinate decarboxylase
NP_001104790.1
NP_034627.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111320.1 → NP_001104790.1  isocitrate dehydrogenase [NADP] cytoplasmic

    See identical proteins and their annotated locations for NP_001104790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK167158, BY787507, CF379827, CF950262
    Consensus CDS
    CCDS15016.1
    UniProtKB/Swiss-Prot
    O88844, Q3UAV7
    UniProtKB/TrEMBL
    Q3TJ51, Q5HZJ8
    Related
    ENSMUSP00000127307.2, ENSMUST00000169032.8
    Conserved Domains (1) summary
    PTZ00435
    Location:1 → 411
    PTZ00435; isocitrate dehydrogenase; Provisional

  2. NM_010497.3 → NP_034627.3  isocitrate dehydrogenase [NADP] cytoplasmic

    See identical proteins and their annotated locations for NP_034627.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK167158, BB868400, CF379827
    Consensus CDS
    CCDS15016.1
    UniProtKB/Swiss-Prot
    O88844, Q3UAV7
    UniProtKB/TrEMBL
    Q3TJ51, Q5HZJ8
    Related
    ENSMUSP00000095316.5, ENSMUST00000097709.11
    Conserved Domains (1) summary
    PTZ00435
    Location:1 → 411
    PTZ00435; isocitrate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65197775..65225638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88844.2 GenPept UniProtKB/Swiss-Prot:O88844

Gene LinkOut

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