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USP51 ubiquitin specific peptidase 51 [ Homo sapiens (human) ]

Gene ID: 158880, updated on 13-Apr-2024

Summary

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Official Symbol
USP51provided by HGNC
Official Full Name
ubiquitin specific peptidase 51provided by HGNC
Primary source
HGNC:HGNC:23086
See related
Ensembl:ENSG00000247746 AllianceGenome:HGNC:23086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables chromatin binding activity; histone binding activity; and thiol-dependent deubiquitinase. Involved in histone deubiquitination; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 4.9), ovary (RPKM 3.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
Xp11.21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55484616..55489848, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54776519..54781751)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55511049..55516281, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29678 Neighboring gene microRNA 4536-1 Neighboring gene microRNA 4536-2 Neighboring gene MAGE family member H1 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:55514837-55515696 Neighboring gene uncharacterized LOC101928692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20867 Neighboring gene MAGE family member E1 pseudogene Neighboring gene PSMA5 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response. Zhou F, et al. Biotechnol Appl Biochem, 2023 Apr. PMID 35856403
  2. USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1. Chen J, et al. J Transl Med, 2023 Jul 8. PMID 37422632, Free PMC Article
  3. Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1. Zhou F, et al. Mol Med Rep, 2020 Aug. PMID 32468048, Free PMC Article
  4. FAT4-USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway. Che X, et al. Am J Transl Res, 2019. PMID 31217854, Free PMC Article
  5. Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones. Ai H, et al. Chembiochem, 2019 Jan 18. PMID 30192049

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
    Title: USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
  2. USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.
    Title: USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1.
  3. The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response.
    Title: The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response.
  4. CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.
    Title: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.
  5. ATXN7L3 and ENY2 orchestrate activities of multiple deubiquitinating enzymes, including USP27x and USP51, and that imbalances in these activities likely potentiate human diseases including cancer.
    Title: ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
  6. USP51 is the deubiquitylating enzyme for H2AK13,15ub and regulates DNA damage response
    Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2A deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 51
Names
deubiquitinating enzyme 51
ubiquitin thioesterase 51
ubiquitin thiolesterase 51
ubiquitin-specific-processing protease 51
NP_958443.1
XP_016884789.1
XP_016884790.1
XP_047297826.1
XP_054182529.1
XP_054182530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021371.1 RefSeqGene

    Range
    4351..9583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_201286.4 → NP_958443.1  ubiquitin carboxyl-terminal hydrolase 51

    See identical proteins and their annotated locations for NP_958443.1

    Status: VALIDATED

    Source sequence(s)
    AL590410
    Consensus CDS
    CCDS14370.1
    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Related
    ENSP00000423333.2, ENST00000500968.4
    Conserved Domains (3) summary
    cd02660
    Location:363 → 704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362 → 703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236 → 296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55484616..55489848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029301.2 → XP_016884790.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Conserved Domains (3) summary
    cd02660
    Location:363 → 704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362 → 703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236 → 296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_017029300.2 → XP_016884789.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Conserved Domains (3) summary
    cd02660
    Location:363 → 704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362 → 703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236 → 296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. XM_047441870.1 → XP_047297826.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    54776519..54781751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326554.1 → XP_054182529.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8

  2. XM_054326555.1 → XP_054182530.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70EK9.1 GenPept UniProtKB/Swiss-Prot:Q70EK9

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