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TTC16 tetratricopeptide repeat domain 16 [ Homo sapiens (human) ]

Gene ID: 158248, updated on 3-Apr-2024

Summary

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Official Symbol
TTC16provided by HGNC
Official Full Name
tetratricopeptide repeat domain 16provided by HGNC
Primary source
HGNC:HGNC:26536
See related
Ensembl:ENSG00000167094 AllianceGenome:HGNC:26536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 9.1), lung (RPKM 0.9) and 2 other tissues See more
Orthologs
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Genomic context

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See TTC16 in Genome Data Viewer
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127716079..127731590)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139923034..139939034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130478358..130493869)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 1 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:130463106-130463614 Neighboring gene microRNA 3911 Neighboring gene peptidyl-tRNA hydrolase 1 homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130476687-130477343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29046 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130478240-130478416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29047 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130480462-130480664 Neighboring gene cilia and flagella associated protein 157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130488893-130489394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130496147-130497053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130504225-130504852 Neighboring gene torsin family 2 member A Neighboring gene SH2 domain containing 3C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130523547-130524424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130524425-130525300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130526508-130527090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20309 Neighboring gene uncharacterized LOC107987132 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130539526-130539796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29050 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130545551-130545741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20310 Neighboring gene Sharpr-MPRA regulatory region 7866 Neighboring gene microRNA 3960 Neighboring gene microRNA 2861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
  2. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  3. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
  4. UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination. Liu J, et al. Nat Cell Biol, 2020 Sep. PMID 32807901
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32780

General protein information

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Preferred Names
tetratricopeptide repeat protein 16
Names
TPR repeat protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317037.2 → NP_001303966.1  tetratricopeptide repeat protein 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK057342, AK302737
    UniProtKB/TrEMBL
    B4DZ42
    Conserved Domains (4) summary
    sd00006
    Location:320 → 346
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:355 → 385
    TPR_1; Tetratricopeptide repeat
    pfam05338
    Location:71 → 130
    DUF717; Protein of unknown function (DUF717)
    pfam13414
    Location:319 → 383
    TPR_11; TPR repeat

  2. NM_144965.3 → NP_659402.1  tetratricopeptide repeat protein 16 isoform 1

    See identical proteins and their annotated locations for NP_659402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057342
    Consensus CDS
    CCDS6875.1
    UniProtKB/Swiss-Prot
    B4DYG4, B5ME24, Q5JU66, Q8NEE8, Q96M72
    UniProtKB/TrEMBL
    B4DZ42
    Related
    ENSP00000362386.3, ENST00000373289.4
    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127716079..127731590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518283.3 → XP_011516585.1  tetratricopeptide repeat protein 16 isoform X1

    UniProtKB/TrEMBL
    B4DZ42
    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  2. XM_011518285.3 → XP_011516587.1  tetratricopeptide repeat protein 16 isoform X3

    UniProtKB/TrEMBL
    B4DZ42
    Conserved Domains (4) summary
    sd00006
    Location:61 → 89
    TPR; TPR repeat [structural motif]
    cd15830
    Location:61 → 149
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
    pfam13371
    Location:260 → 325
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  3. XM_047422835.1 → XP_047278791.1  tetratricopeptide repeat protein 16 isoform X4

  4. XM_011518284.3 → XP_011516586.1  tetratricopeptide repeat protein 16 isoform X2

    UniProtKB/TrEMBL
    B4DZ42
    Conserved Domains (4) summary
    COG0457
    Location:70 → 348
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285 → 311
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:320 → 350
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:319 → 389
    TPR_11; TPR repeat

  5. XM_011518288.3 → XP_011516590.1  tetratricopeptide repeat protein 16 isoform X5

    UniProtKB/TrEMBL
    B4DZ42
    Conserved Domains (3) summary
    sd00006
    Location:156 → 184
    TPR; TPR repeat [structural motif]
    pfam13371
    Location:212 → 277
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:62 → 119
    TPR_11; TPR repeat

  6. XM_047422838.1 → XP_047278794.1  tetratricopeptide repeat protein 16 isoform X12

  7. XM_011518293.3 → XP_011516595.1  tetratricopeptide repeat protein 16 isoform X10

    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  8. XM_047422837.1 → XP_047278793.1  tetratricopeptide repeat protein 16 isoform X9

  9. XM_047422840.1 → XP_047278796.1  tetratricopeptide repeat protein 16 isoform X14

  10. XM_011518295.2 → XP_011516597.1  tetratricopeptide repeat protein 16 isoform X13

    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  11. XM_011518294.3 → XP_011516596.1  tetratricopeptide repeat protein 16 isoform X11

    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  12. XM_011518297.2 → XP_011516599.1  tetratricopeptide repeat protein 16 isoform X15

    Conserved Domains (3) summary
    sd00006
    Location:333 → 359
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  13. XM_011518298.4 → XP_011516600.1  tetratricopeptide repeat protein 16 isoform X16

    Conserved Domains (3) summary
    sd00006
    Location:61 → 89
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:368 → 398
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:62 → 124
    TPR_11; TPR repeat

  14. XM_047422839.1 → XP_047278795.1  tetratricopeptide repeat protein 16 isoform X12

  15. XM_011518292.3 → XP_011516594.1  tetratricopeptide repeat protein 16 isoform X7

    See identical proteins and their annotated locations for XP_011516594.1

    Conserved Domains (2) summary
    PHA03247
    Location:40 → 292
    PHA03247; large tegument protein UL36; Provisional
    COG5099
    Location:391 → 569
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

  16. XM_047422836.1 → XP_047278792.1  tetratricopeptide repeat protein 16 isoform X8

  17. XM_011518290.3 → XP_011516592.1  tetratricopeptide repeat protein 16 isoform X6

    See identical proteins and their annotated locations for XP_011516592.1

    Related
    ENST00000488285.1
    Conserved Domains (3) summary
    sd00006
    Location:155 → 181
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:190 → 220
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:154 → 218
    TPR_11; TPR repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139923034..139939034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362091.1 → XP_054218066.1  tetratricopeptide repeat protein 16 isoform X3

  2. XM_054362090.1 → XP_054218065.1  tetratricopeptide repeat protein 16 isoform X2

  3. XM_054362093.1 → XP_054218068.1  tetratricopeptide repeat protein 16 isoform X5

  4. XM_054362100.1 → XP_054218075.1  tetratricopeptide repeat protein 16 isoform X12

  5. XM_054362089.1 → XP_054218064.1  tetratricopeptide repeat protein 16 isoform X1

  6. XM_054362092.1 → XP_054218067.1  tetratricopeptide repeat protein 16 isoform X4

  7. XM_054362098.1 → XP_054218073.1  tetratricopeptide repeat protein 16 isoform X10

  8. XM_054362097.1 → XP_054218072.1  tetratricopeptide repeat protein 16 isoform X9

  9. XM_054362103.1 → XP_054218078.1  tetratricopeptide repeat protein 16 isoform X14

  10. XM_054362102.1 → XP_054218077.1  tetratricopeptide repeat protein 16 isoform X13

  11. XM_054362099.1 → XP_054218074.1  tetratricopeptide repeat protein 16 isoform X11

  12. XM_054362104.1 → XP_054218079.1  tetratricopeptide repeat protein 16 isoform X15

  13. XM_054362105.1 → XP_054218080.1  tetratricopeptide repeat protein 16 isoform X16

  14. XM_054362101.1 → XP_054218076.1  tetratricopeptide repeat protein 16 isoform X12

  15. XM_054362095.1 → XP_054218070.1  tetratricopeptide repeat protein 16 isoform X7

  16. XM_054362096.1 → XP_054218071.1  tetratricopeptide repeat protein 16 isoform X8

  17. XM_054362094.1 → XP_054218069.1  tetratricopeptide repeat protein 16 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEE8.2 GenPept UniProtKB/Swiss-Prot:Q8NEE8

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