U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lcp2 lymphocyte cytosolic protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155918, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Lcp2provided by RGD
Official Full Name
lymphocyte cytosolic protein 2provided by RGD
Primary source
RGD:619743
See related
Ensembl:ENSRNOG00000005620 AllianceGenome:RGD:619743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slp76
Summary
Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within mast cell activation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane raft. Predicted to be part of TCR signalosome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 212.4), Spleen (RPKM 146.1) and 7 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19146846..19193750)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18642600..18689562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18996523..19043289)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene uncharacterized LOC120095245 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1 Neighboring gene uncharacterized LOC134480773 Neighboring gene similar to human chromosome 5 open reading frame 58 Neighboring gene forkhead box I1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. Devkota S, et al. J Mol Biol, 2015 Aug 28. PMID 25916191, Free PMC Article
  2. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Wu JN, et al. J Immunol, 2004 Jun 1. PMID 15153494
  3. SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. Hendricks-Taylor LR, et al. J Biol Chem, 1997 Jan 10. PMID 8995445
  4. Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. Lasserre R, et al. EMBO J, 2010 Jul 21. PMID 20551903, Free PMC Article
  5. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. Roose JP, et al. PLoS Biol, 2003 Nov. PMID 14624253, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCgamma1 can be primed for ITK-mediated phosphorylation on Y783 by a specific region of the adaptor protein, SLP-76.
    Title: Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mast cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TCR signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lymphocyte cytosolic protein 2
Names
lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130421.2 → NP_569105.1  lymphocyte cytosolic protein 2

    See identical proteins and their annotated locations for NP_569105.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100066
    UniProtKB/TrEMBL
    A0A8J8YIH6, F1LNJ9, Q920L0
    Related
    ENSRNOP00000050879.5, ENSRNOT00000046135.5
    Conserved Domains (3) summary
    cd09522
    Location:10 → 78
    SAM_SLP76; SAM domain of SLP76 subfamily
    smart00454
    Location:12 → 70
    SAM; Sterile alpha motif
    cd09929
    Location:402 → 523
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    19146846..19193750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous