Htr7 5-hydroxytryptamine (serotonin) receptor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr7provided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 7provided by MGI
Primary source: MGI:MGI:99841
See related: Ensembl:ENSMUSG00000024798 AllianceGenome:MGI:99841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT7; 5-HT-X
Summary: Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; immune system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 2.3), cortex adult (RPKM 1.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 30.3 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (35935815..36035533, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (35958415..36058133, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin 5-HT7 receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice.
Title: Serotonin 5-HT(7) receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice.
Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
Title: Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development.
Title: Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development.
Serotonin receptor oligomerization regulates cAMP-based signaling.
Title: Serotonin receptor oligomerization regulates cAMP-based signaling.
the upregulation of miR-29a in the developing hippocampus parallels with the downregulation of 5-HT7R expression.
Title: The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology.
MiRNA-29a is upregulated in and HTR7 is downregulated in irritable bowel syndrome (IBS). HTR7 is a direct target of miRNA-29a. MiRNA-29a plays a role in visceral hyperalgesia pathogenesis of IBS.
Title: MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7.
Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its small es, Cyrillicontent in the mouse brain
Title: [5-HT1A/5-HT7 receptor interplay: Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its сontent in the mouse brain].
Downregulation of the 5-HT7 receptor in the medial prefrontal cortex (mPFC) improves neonatal administration of phencyclidine-induced attentional deficits and impulsive-like overresponding and exacerbates compulsivity. These results suggest that 5-HT7R is involved in the cognitive outcomes of schizophrenia-like symptoms similar to humans.
Title: Downregulation of 5-hydroxytryptamine(7) receptor in the medial prefrontal cortex ameliorates impulsive actions in animal models of schizophrenia.
The present study demonstrated that acute heroin administration resulted in robust disruptions in attention, impulsivity and motivation in mice.
Title: Effects of medial prefrontal cortex 5-HT(7) receptor knockdown on cognitive control after acute heroin administration.
The underlying molecular machinery involves 5-HT7R-mediated activation of MMP-9, which leads to CD44 cleavage followed by Cdc42 activation.
Title: Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

RH66814 (e-PCR)
- UniSTS:39426

Htr7 (e-PCR), detects polymorphism
- UniSTS:527392

HTR7 (e-PCR)
- UniSTS:511811

Htr7 (e-PCR), detects polymorphism
- UniSTS:511811

Htr7 (e-PCR), detects polymorphism
- UniSTS:143431

Htr7 (e-PCR), detects polymorphism
- UniSTS:143432

UniSTS:495969 (e-PCR)
- UniSTS:495969

Htr7 (e-PCR), detects polymorphism
- UniSTS:495969

RH143843 (e-PCR)
- UniSTS:233089

D1M19Mit63 (e-PCR)
- UniSTS:128404

D19Mit63 (e-PCR), detects polymorphism
- UniSTS:128404

NoName (e-PCR)
- UniSTS:492230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	ISO Inferred from Sequence Orthology more info
involved_in serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 7

Names: serotonin receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347442.2 → NP_001334371.1 5-hydroxytryptamine receptor 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as 5-HT7c) represents the longest transcript and encodes the longest isoform (2). 5-HT7c cited in PMID 18793707.

Source sequence(s)

AC133874

Consensus CDS

CCDS84436.1

UniProtKB/TrEMBL

B6VJS3, Q3UUR3

Related

ENSMUSP00000097105.4, ENSMUST00000099505.4
NM_001360297.1 → NP_001347226.1 5-hydroxytryptamine receptor 7 isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 2. The encoded isoform (4) has a shorter N-terminus, compared to isoform (2).

Source sequence(s)

AC133874

Conserved Domains (2) summary

cd14964
Location:3 → 19

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001360298.1 → NP_001347227.1 5-hydroxytryptamine receptor 7 isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 2. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 2. Variants 5 and 6 encode the same protein.

Source sequence(s)

AC133874

Conserved Domains (2) summary

cd14964
Location:3 → 19

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001360300.1 → NP_001347229.1 5-hydroxytryptamine receptor 7 isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences, compared to variant 2. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 2. Variants 5 and 6 encode the same protein.

Source sequence(s)

AC133874, AK139197

Conserved Domains (2) summary

cd14964
Location:3 → 19

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001360318.1 → NP_001347247.1 5-hydroxytryptamine receptor 7 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as 5-HT7b) differs in the 3' coding region and 3' UTR, compared to variant 2. The encoded isoform (3) has a shorter C-terminus, compared to isoform 2. 5-HT7b cited in PMID 18793707.

Source sequence(s)

AC133874

Consensus CDS

CCDS89383.1

UniProtKB/TrEMBL

B6VJS2, Q3UUR3

Related

ENSMUSP00000126150.2, ENSMUST00000166074.2

Conserved Domains (1) summary

cd15329
Location:100 → 398

7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_008315.3 → NP_032341.2 5-hydroxytryptamine receptor 7 isoform 1

See identical proteins and their annotated locations for NP_032341.2

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as 5-HT7a) lacks an alternate exon in the 3' coding region, compared to variant 2. The encoded isoform (1) is shorter and has a distinct C-terminus, compared to isoform 2. 5-HT7a cited in PMID 18793707.

Source sequence(s)

AC133874, BC116986

Consensus CDS

CCDS29769.1

UniProtKB/Swiss-Prot

P32304, Q14A50

UniProtKB/TrEMBL

Q3UUR3

Related

ENSMUSP00000126847.2, ENSMUST00000164639.8

Conserved Domains (2) summary

pfam00001
Location:101 → 387

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:101 → 222

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

35935815..36035533 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250756.2 → XP_030106616.1 5-hydroxytryptamine receptor 7 isoform X1

Conserved Domains (2) summary

cd14964
Location:3 → 19

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 197

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily