Htr2b 5-hydroxytryptamine (serotonin) receptor 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr2bprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Bprovided by MGI
Primary source: MGI:MGI:109323
See related: Ensembl:ENSMUSG00000026228 AllianceGenome:MGI:109323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT2B; 5-HT-2B; 5-HT-2F
Summary: Enables G protein-coupled serotonin receptor activity; GTPase activator activity; and serotonin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to temperature stimulus; and protein kinase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within heart development. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; reproductive system; and sensory organ. Used to study hypertrophic cardiomyopathy. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (86025268..86043960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86097546..86116231, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice.
Title: Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT(2B) Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X(7) Receptors in Mice.
Improved visual discrimination learning in mice with partial 5-HT2B gene deletion.
Title: Improved visual discrimination learning in mice with partial 5-HT2B gene deletion.
Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.
Title: Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.
Bladder outlet obstruction disrupts circadian bladder function in mice.
Title: Bladder outlet obstruction disrupts circadian bladder function in mice.
Our results make clear that peripheral HTR2B expression is required specifically for itch behaviors evoked by SSRIs, 5-HT, and alpha-Me-5HT.
Title: Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
these observations indicate that the 5-HT2B receptor acts as a direct positive modulator of serotonin Pet1-positive neurons in an opposite way as the known 5-HT1A negative autoreceptor.
Title: Positive regulation of raphe serotonin neurons by serotonin 2B receptors.
Our results indicate that prolonged Htr2b activation in murine beta-cells decreases glucose-stimulated insulin secretion and mitochondrial activity by mechanisms likely dependent on enhanced PGC1a/PPARygexpression.
Title: Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Title: Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT(2C) protomers.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2+) flux that enhance mitochondrial metabolism.
Title: Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Title: Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Htr2b (e-PCR), detects polymorphism
- UniSTS:143423

Htr2b (e-PCR), detects polymorphism
- UniSTS:143424

Htr2b (e-PCR), detects polymorphism
- UniSTS:495966

AJ012488 (e-PCR)
- UniSTS:163256

AV377389 (e-PCR)
- UniSTS:178426

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled serotonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed
enables serotonin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to serotonin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to temperature stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of behavior	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2B

Names: NP75 protein; serotonin receptor 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008311.3 → NP_032337.2 5-hydroxytryptamine receptor 2B

See identical proteins and their annotated locations for NP_032337.2

Status: VALIDATED

Source sequence(s)

AC157768

Consensus CDS

CCDS35644.1

UniProtKB/Swiss-Prot

Q02152, Q8JZK5, Q9QWS2

Related

ENSMUSP00000027431.7, ENSMUST00000027431.7

Conserved Domains (2) summary

pfam00001
Location:70 → 379

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 161

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

86025268..86043960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529146.4 → XP_006529209.1 5-hydroxytryptamine receptor 2B isoform X1

See identical proteins and their annotated locations for XP_006529209.1

Conserved Domains (2) summary

cd14964
Location:55 → 81

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:54 → 413

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_030250037.1 → XP_030105897.1 5-hydroxytryptamine receptor 2B isoform X2

Conserved Domains (2) summary

cd14964
Location:88 → 117

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:59 → 272

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily