Hspa4 heat shock protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa4provided by MGI
Official Full Name: heat shock protein 4provided by MGI
Primary source: MGI:MGI:1342292
See related: Ensembl:ENSMUSG00000020361 AllianceGenome:MGI:1342292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 70kDa; APG-2; Hsp110; Hsp70RY; mKIAA4025
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in cytoplasm; extracellular exosome; and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 44.3), adrenal adult (RPKM 30.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.91 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53150641..53191306, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53259814..53300479, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.
Title: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.
Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis.
Title: Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis.
Data show that heat shock protein 70 (HSP70) induction by geranylgeranylacetone (GGA) was effective against N-methyl-N-nitrosourea (MNU-induced photoreceptor cell loss.
Title: Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice.
Upregulation of HSPA4 would control apoptosis of inflammatory cells and immune response in the gut, which might develop treatment resistance in inflammatory bowel disease.
Title: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease.
regulates the expression of SDF-1 and Twist in fibroblasts, thereby controlling gastric ulcer healing
Title: Heat shock protein A4 controls cell migration and gastric ulcer healing.
Inhibition of Apg-2 by shRNA not only decreased cell proliferation, but also induced cell apoptosis in BCR/ABL positive chronic myeloid leukemia cells (BaF3-BCR/ABL, BaF3-BCR/ABL(T315I)).
Title: Proteomic-based identification of Apg-2 as a therapeutic target for chronic myeloid leukemia.
PSMB8, ALDH1A1, and HSPA4 were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
Title: Assessment of the risk of blastomere biopsy during preimplantation genetic diagnosis in a mouse model: reducing female ovary function with an increase in age by proteomics method.
HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth.
Title: Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.
study demonstrates that lack of HSPA4 leads to cardiac hypertrophy and fibrosis; data reveal the distinct, non-redundant role of HSPA4 in the protein quality control that maintains the proper protein folding and homeostasis in cardiomyocytes
Title: Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis.
Data suggest HSPA4 is required for spermatogenesis. All homozygous HSPA4-deficient mice are apparently healthy; HSPA4 is expressed as early as E13.5 in male gonad; increased number of HSPA4-deficient males are infertile, whereas females are fertile.
Title: Heat-shock protein HSPA4 is required for progression of spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock 70 kDa protein 4

Names: heat shock 70-related protein APG-2; heat shock protein, 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.