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Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 [ Mus musculus (house mouse) ]

Gene ID: 15519, updated on 9-Dec-2024

Summary

Official Symbol
Hsp90aa1provided by MGI
Official Full Name
heat shock protein 90, alpha (cytosolic), class A member 1provided by MGI
Primary source
MGI:MGI:96250
See related
Ensembl:ENSMUSG00000021270 AllianceGenome:MGI:96250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1
Summary
Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including cellular response to heat; positive regulation of nitric oxide biosynthetic process; and protein folding. Located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues See more
Orthologs
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Genomic context

See Hsp90aa1 in Genome Data Viewer
Location:
12 F1; 12 60.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110657470..110662829, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110691036..110696395, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K19 gene Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene WD repeat domain 20 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene MOK protein kinase Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Transgenic (1) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 53
Function Evidence Code Pubs
enables ATP binding  
enables ATP binding  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATP-dependent protein folding chaperone  
enables CTP binding  
enables CTP binding  
enables DNA polymerase binding  
enables DNA polymerase binding  
enables GTP binding  
enables GTP binding  
enables GTPase binding  
enables GTPase binding  
enables Rho GDP-dissociation inhibitor binding  
enables Rho GDP-dissociation inhibitor binding  
enables TPR domain binding  
enables TPR domain binding  
enables UTP binding  
enables UTP binding  
enables dATP binding  
enables dATP binding  
enables disordered domain specific binding  
enables disordered domain specific binding  
enables histone deacetylase binding  
enables histone deacetylase binding  
enables identical protein binding PubMed 
enables identical protein binding  
enables mRNA binding  
enables mRNA binding  
enables nitric-oxide synthase regulator activity PubMed 
enables nitric-oxide synthase regulator activity  
enables protein binding PubMed 
enables protein folding chaperone PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein phosphatase binding  
enables protein phosphatase binding  
enables protein tyrosine kinase binding  
enables protein tyrosine kinase binding  
enables scaffold protein binding  
enables scaffold protein binding  
enables sulfonylurea receptor binding  
enables sulfonylurea receptor binding  
enables tau protein binding  
enables tau protein binding  
enables transmembrane transporter binding  
enables transmembrane transporter binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
enables unfolded protein binding  
enables unfolded protein binding PubMed 
Items 1 - 25 of 53
Items 1 - 25 of 60
Process Evidence Code Pubs
involved_in activation of innate immune response  
involved_in activation of innate immune response  
involved_in cardiac muscle cell apoptotic process  
involved_in cellular response to heat  
involved_in cellular response to heat PubMed 
involved_in cellular response to virus  
involved_in cellular response to virus  
involved_in chaperone-mediated protein complex assembly  
involved_in chaperone-mediated protein complex assembly  
involved_in neurofibrillary tangle assembly  
involved_in neuron migration  
involved_in neuron migration  
involved_in nitric oxide biosynthetic process PubMed 
involved_in positive regulation of cardiac muscle contraction  
involved_in positive regulation of cell size  
involved_in positive regulation of cell size  
involved_in positive regulation of cytotoxic T cell differentiation PubMed 
involved_in positive regulation of defense response to virus by host  
involved_in positive regulation of defense response to virus by host  
involved_in positive regulation of interferon-beta production  
involved_in positive regulation of interferon-beta production  
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of nitric oxide biosynthetic process PubMed 
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of protein import into nucleus  
involved_in positive regulation of protein import into nucleus  
involved_in positive regulation of protein phosphorylation  
involved_in positive regulation of protein polymerization  
involved_in positive regulation of protein polymerization  
involved_in positive regulation of tau-protein kinase activity  
involved_in protein folding  
involved_in protein folding PubMed 
involved_in protein insertion into mitochondrial outer membrane  
involved_in protein insertion into mitochondrial outer membrane  
involved_in protein refolding PubMed 
involved_in protein stabilization  
involved_in protein stabilization  
involved_in protein stabilization  
involved_in regulation of apoptotic process  
involved_in regulation of apoptotic process  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in regulation of protein localization PubMed 
involved_in regulation of protein ubiquitination  
involved_in regulation of protein ubiquitination  
involved_in response to antibiotic  
involved_in response to cocaine  
involved_in response to cold  
involved_in response to estrogen  
involved_in response to heat  
involved_in response to salt stress  
involved_in response to unfolded protein PubMed 
involved_in response to xenobiotic stimulus  
involved_in skeletal muscle contraction  
involved_in telomerase holoenzyme complex assembly  
involved_in telomerase holoenzyme complex assembly  
involved_in telomere maintenance via telomerase  
acts_upstream_of_positive_effect telomere maintenance via telomerase  
Items 1 - 25 of 60
Items 1 - 20 of 45
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in axonal growth cone PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in brush border membrane  
located_in brush border membrane  
located_in cell surface  
located_in cell surface  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in cytosol PubMed 
located_in dendritic growth cone PubMed 
located_in intracellular anatomical structure PubMed 
located_in melanosome  
located_in mitochondrion  
located_in mitochondrion  
located_in myelin sheath PubMed 
is_active_in myelin sheath  
located_in myelin sheath  
is_active_in neuronal cell body  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm PubMed 
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
part_of protein-containing complex  
part_of protein-containing complex PubMed 
part_of protein-containing complex  
located_in sperm flagellum  
located_in sperm mitochondrial sheath  
located_in sperm mitochondrial sheath  
located_in sperm plasma membrane  
located_in sperm plasma membrane  
Items 1 - 20 of 45

General protein information

Preferred Names
heat shock protein HSP 90-alpha
Names
HSP 86
HSP86
TSTA
heat shock 86 kDa
heat shock protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1
heat shock protein, 1
heat shock protein, 86 kDa 1
heat shock protein, 89 kDa
tumor-specific transplantation 86 kDa antigen
NP_034610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010480.5NP_034610.1  heat shock protein HSP 90-alpha

    See identical proteins and their annotated locations for NP_034610.1

    Status: PROVISIONAL

    Source sequence(s)
    AC152827, AL596265
    Consensus CDS
    CCDS26172.1
    UniProtKB/Swiss-Prot
    P07901
    UniProtKB/TrEMBL
    Q3TKA2, Q80Y52
    Related
    ENSMUSP00000091921.5, ENSMUST00000094361.11
    Conserved Domains (3) summary
    smart00387
    Location:40191
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:18733
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:196723
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110657470..110662829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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