SLC2A7 solute carrier family 2 member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC2A7provided by HGNC
Official Full Name: solute carrier family 2 member 7provided by HGNC
Primary source: HGNC:HGNC:13445
See related: Ensembl:ENSG00000197241 MIM:610371; AllianceGenome:HGNC:13445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUT7; GLUT-7; hGLUT7
Summary: SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (8992534..9026423, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (8526240..8560063, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (9063032..9086482, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a hydrophobic residue is a key determinant of fructose transport in SLC2A7
Title: Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7).
Unusual substrate specificity and close sequence identity with GLUT5. GLUT7 may represent intermediate between class II GLUTs and class I member GLUT2. Comparison may give key to structural determinants for recognition of fructose as a substrate.
Title: Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables hexose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sugar transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
NOT involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info
involved_in monosaccharide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 7

Names: glucose transporter type 7; intestinal facilitative glucose transporter 7; solute carrier family 2 (facilitated glucose transporter), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207420.3 → NP_997303.2 solute carrier family 2, facilitated glucose transporter member 7

See identical proteins and their annotated locations for NP_997303.2

Status: VALIDATED

Source sequence(s)

AL158048

Consensus CDS

CCDS98.2

UniProtKB/Swiss-Prot

A2A333, Q6PXP3

Related

ENSP00000383698.1, ENST00000400906.2

Conserved Domains (1) summary

cd17432
Location:26 → 477

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

8992534..9026423 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540824.3 → XP_011539126.1 solute carrier family 2, facilitated glucose transporter member 7 isoform X1

Conserved Domains (2) summary

cd06174
Location:100 → 439

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:26 → 441

Sugar_tr; Sugar (and other) transporter
XM_011540825.3 → XP_011539127.1 solute carrier family 2, facilitated glucose transporter member 7 isoform X2

Conserved Domains (1) summary

cd06174
Location:100 → 367

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

8526240..8560063 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054334701.1 → XP_054190676.1 solute carrier family 2, facilitated glucose transporter member 7 isoform X1
XM_054334702.1 → XP_054190677.1 solute carrier family 2, facilitated glucose transporter member 7 isoform X2