U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 [ Mus musculus (house mouse) ]

Gene ID: 15496, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Hsd3b5provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5provided by MGI
Primary source
MGI:MGI:104645
See related
Ensembl:ENSMUSG00000038092 AllianceGenome:MGI:104645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Acts upstream of or within response to stilbenoid. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; gut; liver and biliary system; metanephros; and skeletal muscle. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 54.7) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hsd3b5 in Genome Data Viewer
Location:
3 F2.2; 3 42.82 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98525952..98552850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98618636..98645534, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 697 Neighboring gene predicted gene 5853 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08480 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins. Abbaszade IG, et al. Mol Endocrinol, 1995 Sep. PMID 7491113
  2. Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy. Abbaszade IG, et al. Endocrinology, 1997 Apr. PMID 9075693
  3. Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development. Park CH, et al. Mol Cell Endocrinol, 1996 Feb 5. PMID 8647315
  4. Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Keeney DS, et al. Mol Endocrinol, 1995 Aug. PMID 7476982
  5. Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice. Suraweera N, et al. Hum Mol Genet, 2006 Dec 1. PMID 17062636

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-keto sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippocampus development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to corticosterone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NADPH-dependent 3-keto-steroid reductase Hsd3b5
Names
3 beta-hydroxysteroid dehydrogenase type 5
3 beta-hydroxysteroid dehydrogenase type V
3(beta)HSDV
3-beta-HSD V
3-beta-hydroxy-5-ene steroid dehydrogenase
NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
dihydrotestosterone 3-ketoreductase
hydroxysteroid dehydrogenase-5, delta<5>-3-beta
progesterone reductase
NP_032321.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008295.2 → NP_032321.2  NADPH-dependent 3-keto-steroid reductase Hsd3b5

    See identical proteins and their annotated locations for NP_032321.2

    Status: VALIDATED

    Source sequence(s)
    AC122044, BY097811, BY460328
    Consensus CDS
    CCDS17666.1
    UniProtKB/Swiss-Prot
    Q61694, Q91X27
    Related
    ENSMUSP00000041442.5, ENSMUST00000044094.6
    Conserved Domains (2) summary
    pfam01073
    Location:7 → 287
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98525952..98552850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61694.4 GenPept UniProtKB/Swiss-Prot:Q61694

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous