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Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 [ Mus musculus (house mouse) ]

Gene ID: 15486, updated on 5-Mar-2024

Summary

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Official Symbol
Hsd17b2provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 2provided by MGI
Primary source
MGI:MGI:1096386
See related
Ensembl:ENSMUSG00000031844 AllianceGenome:MGI:1096386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within in utero embryonic development and placenta development. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and retina. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 84.5), colon adult (RPKM 79.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Hsd17b2 in Genome Data Viewer
Location:
8 E1; 8 64.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118427752..118485767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117700982..117759030)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31717 Neighboring gene predicted gene, 38416 Neighboring gene predicted gene, 31774 Neighboring gene predicted gene, 39261 Neighboring gene STARR-positive B cell enhancer mm9_chr8:120303396-120303696 Neighboring gene STARR-positive B cell enhancer ABC_E9744 Neighboring gene M phase phosphoprotein 6 Neighboring gene STARR-positive B cell enhancer ABC_E1377

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Sher LB, et al. Calcif Tissue Int, 2006 Aug. PMID 16927049
  2. Androgen receptor and 17beta-HSD type 2 regulation in neonatal mouse lung development. Boucher E, et al. Mol Cell Endocrinol, 2009 Nov 13. PMID 19576262
  3. Ontogeny of 17beta-hydroxysteroid dehydrogenase type 2 mRNA expression in the developing mouse placenta and fetus. Mustonen M, et al. Mol Cell Endocrinol, 1997 Oct 31. PMID 9406847
  4. 17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant. Tremblay Y, et al. Mol Cell Endocrinol, 2006 Mar 27. PMID 16337335
  5. Expression of mouse 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: localization from implantation to late pregnancy. Nokelainen P, et al. Endocrinology, 2000 Feb. PMID 10650959

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate temporal and spatial regulation of androgen receptor and 17beta-HSD 2 during the sacculo-alveolar transition period of mouse lung development suggesting control of androgen action.[17beta HSD2]
    Title: Androgen receptor and 17beta-HSD type 2 regulation in neonatal mouse lung development.
  2. HSD17B2 plays a role in the cellular organization of the mouse placenta.
    Title: Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene.
  3. Hsd17b2 has a role in cortical bone acquisition and full osteoblast differentiation
    Title: Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables testosterone dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
estradiol 17-beta-dehydrogenase 2
Names
17 HSD type 2
17-beta-HSD 2
17-beta-hydroxysteroid dehydrogenase 2
17-beta-hydroxysteroid dehydrogenase type 2
testosterone 17-beta-dehydrogenase
NP_001411758.1
NP_032316.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424829.1 → NP_001411758.1  estradiol 17-beta-dehydrogenase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112964, AC122036

  2. NM_008290.3 → NP_032316.2  estradiol 17-beta-dehydrogenase 2 isoform 1

    See identical proteins and their annotated locations for NP_032316.2

    Status: VALIDATED

    Source sequence(s)
    AC112964, AC122036
    Consensus CDS
    CCDS40491.1
    UniProtKB/Swiss-Prot
    O08898, P51658
    Related
    ENSMUSP00000034304.8, ENSMUST00000034304.9
    Conserved Domains (2) summary
    cd09805
    Location:84 → 364
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:84 → 279
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    118427752..118485767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51658.2 GenPept UniProtKB/Swiss-Prot:P51658

Gene LinkOut

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