Rida reactive intermediate imine deaminase A homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ridaprovided by MGI
Official Full Name: reactive intermediate imine deaminase A homologprovided by MGI
Primary source: MGI:MGI:1095401
See related: Ensembl:ENSMUSG00000022323 AllianceGenome:MGI:1095401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HR12; HRP12; Hrsp12
Summary: Predicted to enable several functions, including 2-iminobutanoate deaminase activity; endoribonuclease activity, producing 3'-phosphomonoesters; and identical protein binding activity. Predicted to be involved in negative regulation of epithelial cell proliferation; negative regulation of gene expression; and organonitrogen compound catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 155.7), liver adult (RPKM 100.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 14.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (34484168..34495392, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (34484022..34495246, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hrsp12 (e-PCR), detects polymorphism
- UniSTS:143404

U50631 (e-PCR)
- UniSTS:125762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-iminobutanoate deaminase activity	ISO Inferred from Sequence Orthology more info
enables 2-iminobutanoate/2-iminopropanoate deaminase	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	ISO Inferred from Sequence Orthology more info
enables deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ion binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in organonitrogen compound catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in organonitrogen compound catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-iminobutanoate/2-iminopropanoate deaminase

Names: heat-responsive protein 12; ribonuclease UK114; translation inhibitor L-PSP ribonuclease

NP_032313.2

EC 3.5.99.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.