Hpx hemopexin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpxprovided by MGI
Official Full Name: hemopexinprovided by MGI
Primary source: MGI:MGI:105112
See related: Ensembl:ENSMUSG00000030895 AllianceGenome:MGI:105112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hx; Hpxn
Summary: Predicted to enable heme binding activity. Acts upstream of or within several processes, including hemoglobin metabolic process; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; embryo; liver; liver left lobe; and liver right lobe. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 1827.7), liver E18 (RPKM 441.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105240818..105249323, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (105591611..105600116, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia.
Title: Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia.
Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease.
Title: Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease.
Hemopexin expressed bye neural stem cells regulates adult neurogenesis in the subventricular zone/olfactory bulb pathway.
Title: Hemopexin is required for adult neurogenesis in the subventricular zone/olfactory bulb pathway.
Ablation of Hpx in vivo affected the polarization state of lipopolysaccharide (LPS)-stimulated microglia, as mirrored by a lower percentage of M2 microglia and a higher percentage of M1 microglia in the lesion site, which delayed the recovery and exacerbated the behavioral dysfunction after SCI.
Title: Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state.
Proteomic characterization of the heart and skeletal muscle reveals widespread arginine ADP-ribosylation by the ARTC1 ectoenzyme with hemopexin being its target protein.
Title: Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
Overexpression of the PEX isoform of MMP3 promoted proliferation and migration of the rapidly metastatic cells in vitro. Nuclear PEX domain/MMP3 localized in primary tumor-stroma marginal area and lung-metastatic tumor nodules.
Title: The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.
this study shows that hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress
Title: Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.
Hemopexin plays a novel protective role in alleviating heme-induced oxidative stress, improving inflammatory properties of high-density lipoprotein, macrophage phenotype and function, and inhibiting the development of atherosclerosis in apoE(-/-) mice.
Title: Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.
This study demonstrated that Deletion of the hemopexin aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
In models for sepsis or burns, mean plasma hemopexin levels were increased above baseline.
Title: Hemopexin in severe inflammation and infection: mouse models and human diseases.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC303338P3 (e-PCR)
- UniSTS:272499

Hpx (e-PCR), detects polymorphism
- UniSTS:519043

Hpx (e-PCR), detects polymorphism
- UniSTS:519044

RH127844 (e-PCR)
- UniSTS:211154

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemoglobin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of response to type II interferon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hemopexin

NP_059067.2

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017371.2 → NP_059067.2 hemopexin precursor

See identical proteins and their annotated locations for NP_059067.2

Status: VALIDATED

Source sequence(s)

AA985967, AK145928, BY088352

Consensus CDS

CCDS21654.1

UniProtKB/Swiss-Prot

P97824, Q3UKP2, Q8WUP0, Q91X72

Related

ENSMUSP00000033185.9, ENSMUST00000033185.10

Conserved Domains (1) summary

cd00094
Location:47 → 230

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...