U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lipc lipase, hepatic [ Mus musculus (house mouse) ]

Gene ID: 15450, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Lipcprovided by MGI
Official Full Name
lipase, hepaticprovided by MGI
Primary source
MGI:MGI:96216
See related
Ensembl:ENSMUSG00000032207 AllianceGenome:MGI:96216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HL; Hpl
Summary
Enables lipase activity. Acts upstream of or within cholesterol homeostasis; cholesterol metabolic process; and cholesterol transport. Located in extracellular space. Is expressed in liver and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 48.1), liver E18 (RPKM 35.8) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 D; 9 39.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70705410..70859503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70798128..70952221, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2903 Neighboring gene predicted gene, 31872 Neighboring gene a disintegrin and metallopeptidase domain 10 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24559 Neighboring gene STARR-seq mESC enhancer starr_24560 Neighboring gene VISTA enhancer mm190 Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24562 Neighboring gene STARR-seq mESC enhancer starr_24564 Neighboring gene predicted gene, 32017 Neighboring gene predicted gene, 46118 Neighboring gene predicted gene, 32074

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis. Andrés-Blasco I, et al. J Endocrinol, 2015 Dec. PMID 26423094
  2. Genetic analysis of ligation-induced neointima formation in an F2 intercross of C57BL/6 and FVB/N inbred mouse strains. Östergren C, et al. PLoS One, 2015. PMID 25875831, Free PMC Article
  3. In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice. Chen J, et al. Physiol Rep, 2015 Apr. PMID 25862097, Free PMC Article
  4. Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr. Hime NJ, et al. J Lipid Res, 2014 Sep. PMID 24818611, Free PMC Article
  5. Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity. Bartelt A, et al. Bone, 2014 May. PMID 24440515

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
    Title: Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
  2. The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas.
    Title: Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.
  3. hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis.
    Title: Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis.
  4. Bone marrow (BM)-derived hepatic lipase mitigates the HDL-lowering, HDL-modulating, and cholesterol-raising effects of BM-derived cholesteryl ester transfer protein.
    Title: Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr.
  5. HL expressed by osteoblasts has an impact on osteoblast OPG expression and that lack of HL leads to increased bone mass.
    Title: Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity.
  6. Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids.
    Title: Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.
  7. interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function.
    Title: LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells.
  8. Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
    Title: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
  9. Data show a novel pathway involving HL hydrolysis of VLDL that activates PPARdelta through generation of specific monounsaturated fatty acids.
    Title: VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.
  10. These results demonstrated that fatty acid synthase and hepatic lipase might be FXR-regulated genes in liver cells.
    Title: Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables apolipoprotein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables chylomicron binding ISO
Inferred from Sequence Orthology
more info
  
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
  
enables triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cholesterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in chylomicron remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of plasma lipoprotein particle levels ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
hepatic triacylglycerol lipase
Names
hepatic lipase
lipase member C
lysophospholipase
phospholipase A1
NP_001311401.1
NP_001311402.1
NP_001398716.1
NP_001398717.1
NP_001398718.1
NP_032306.2
XP_006510880.1
XP_006510881.1
XP_036010505.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324472.1 → NP_001311401.1  hepatic triacylglycerol lipase isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841, BY337256
    Consensus CDS
    CCDS23324.1
    UniProtKB/Swiss-Prot
    P27656, Q8VC44
    Conserved Domains (2) summary
    cd01758
    Location:353 → 488
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:18 → 350
    Lipase

  2. NM_001324473.1 → NP_001311402.1  hepatic triacylglycerol lipase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. Variant 3 is predicted to encode a protein (isoform 2) which lacks the signal peptide that is present in isoform 1.
    Source sequence(s)
    BC021841, BY337256
    Consensus CDS
    CCDS90617.1
    UniProtKB/TrEMBL
    Q3TYU0
    Related
    ENSMUSP00000149185.2, ENSMUST00000216798.2
    Conserved Domains (3) summary
    cd00707
    Location:1 → 261
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:268 → 403
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1 → 265
    Lipase; Lipase

  3. NM_001411787.1 → NP_001398716.1  hepatic triacylglycerol lipase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701
    UniProtKB/Swiss-Prot
    P27656, Q8VC44

  4. NM_001411788.1 → NP_001398717.1  hepatic triacylglycerol lipase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701

  5. NM_001411789.1 → NP_001398718.1  hepatic triacylglycerol lipase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701

  6. NM_008280.2 → NP_032306.2  hepatic triacylglycerol lipase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032306.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841
    Consensus CDS
    CCDS23324.1
    UniProtKB/Swiss-Prot
    P27656, Q8VC44
    Related
    ENSMUSP00000034731.9, ENSMUST00000034731.10
    Conserved Domains (2) summary
    cd01758
    Location:353 → 488
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:18 → 350
    Lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70705410..70859503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154612.1 → XP_036010505.1  hepatic triacylglycerol lipase isoform X3

    Conserved Domains (2) summary
    cd01758
    Location:284 → 419
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1 → 281
    Lipase

  2. XM_006510817.3 → XP_006510880.1  hepatic triacylglycerol lipase isoform X3

    Conserved Domains (2) summary
    cd01758
    Location:284 → 419
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1 → 281
    Lipase

  3. XM_006510818.4 → XP_006510881.1  hepatic triacylglycerol lipase isoform X4

    Conserved Domains (1) summary
    pfam00151
    Location:18 → 366
    Lipase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27656.2 GenPept UniProtKB/Swiss-Prot:P27656

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous