Hpse heparanase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpseprovided by MGI
Official Full Name: heparanaseprovided by MGI
Primary source: MGI:MGI:1343124
See related: Ensembl:ENSMUSG00000035273 AllianceGenome:MGI:1343124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hpa; HSE1; Hpr1
Summary: This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]
Expression: Broad expression in spleen adult (RPKM 5.5), colon adult (RPKM 5.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E4; 5 48.51 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (100827350..100867582, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (100679484..100719716, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Title: Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells.
Title: Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells.
Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.
Title: Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.
Osteoblasts-derived exosomes regulate osteoclast differentiation through miR-503-3p/Hpse axis.
Title: Osteoblasts-derived exosomes regulate osteoclast differentiation through miR-503-3p/Hpse axis.
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.
Title: Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.
Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease.
Title: Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.
Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.
Title: Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.
Dichotomic role of heparanase in a murine model of metabolic syndrome.
Title: Dichotomic role of heparanase in a murine model of metabolic syndrome.
Cytokine induction by chemotherapy was not observed in macrophages isolated from heparanase-knockout mice. Mechanistically, paclitaxel and cisplatin activated methylation of histone H3 on lysine 4 (H3K4) in wild-type but not in heparanase-knockout macrophages. This epigenetic, heparanase-dependent host-response mechanism adds a new perspective to the tumor-promoting functions of chemotherapy.
Title: Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
Heparanase is preferentially expressed in experimental obesity-associated breast tumors. Heparanase deficiency abolished obesity-accelerated tumor progression in vivo. Heparanase was required for adipose tissue macrophages to produce inflammatory mediators responsible for local induction of aromatase, a rate-limiting enzyme in estrogen biosynthesis. Estrogen upregulated heparanase in hormone-responsive breast tumors.
Title: Heparanase Accelerates Obesity-Associated Breast Cancer Progression.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (6) 1 citation

General gene information

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Markers

G47943 (e-PCR)
- UniSTS:108709

AA690179 (e-PCR)
- UniSTS:207837

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables heparanase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to heparanase activity	ISO Inferred from Sequence Orthology more info
enables heparanase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis involved in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis involved in wound healing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in heparin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of heparanase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal lumen	ISO Inferred from Sequence Orthology more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: heparanase

Names: endo-glucoronidase; endoglycosidase heparanase

NP_690016.1

EC 3.2.1.166

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.