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Hp1bp3 heterochromatin protein 1, binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 15441, updated on 18-Apr-2024

Summary

Official Symbol
Hp1bp3provided by MGI
Official Full Name
heterochromatin protein 1, binding protein 3provided by MGI
Primary source
MGI:MGI:109369
See related
Ensembl:ENSMUSG00000028759 AllianceGenome:MGI:109369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hp1bp74
Summary
Predicted to enable DNA binding activity and nucleosome binding activity. Predicted to be involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Predicted to be located in nuclear speck. Predicted to be part of nucleosome. Predicted to be active in chromosome and nucleus. Orthologous to human HP1BP3 (heterochromatin protein 1 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 21.0), whole brain E14.5 (RPKM 19.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D3; 4 70.03 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137943781..137971994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138216470..138244683)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene RIKEN cDNA 1700095J12 gene Neighboring gene microRNA 6399 Neighboring gene SH2 domain containing 5 Neighboring gene predicted gene, 54278 Neighboring gene kinesin family member 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28927

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in heterochromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heterochromatin organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nucleus size ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterochromatin protein 1-binding protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122896.3NP_001116368.1  heterochromatin protein 1-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001116368.1

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    Consensus CDS
    CCDS51334.1
    UniProtKB/TrEMBL
    Z4YKA3
    Related
    ENSMUSP00000095447.4, ENSMUST00000097836.10
    Conserved Domains (5) summary
    PRK13808
    Location:417516
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:24122
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:119203
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308374
    Linker_histone; linker histone H1 and H5 family
  2. NM_001122897.3NP_001116369.1  heterochromatin protein 1-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001116369.1

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    Consensus CDS
    CCDS38927.1
    UniProtKB/Swiss-Prot
    A2AM64, A2AM68, Q3TEA8, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
    UniProtKB/TrEMBL
    Z4YKB8
    Related
    ENSMUSP00000132614.2, ENSMUST00000165861.8
    Conserved Domains (5) summary
    PRK13808
    Location:455554
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:14160
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:157241
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346412
    Linker_histone; linker histone H1 and H5 family
  3. NM_001285478.2NP_001272407.1  heterochromatin protein 1-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001272407.1

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    Consensus CDS
    CCDS38927.1
    UniProtKB/Swiss-Prot
    A2AM64, A2AM68, Q3TEA8, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
    UniProtKB/TrEMBL
    Z4YKB8
    Related
    ENSMUSP00000101452.2, ENSMUST00000105826.8
    Conserved Domains (5) summary
    PRK13808
    Location:455554
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:14160
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:157241
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346412
    Linker_histone; linker histone H1 and H5 family
  4. NM_001285479.2NP_001272408.1  heterochromatin protein 1-binding protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001272408.1

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    UniProtKB/TrEMBL
    Z4YKB8
    Conserved Domains (4) summary
    smart00526
    Location:252318
    H15; Domain in histone families 1 and 5
    cd00073
    Location:157241
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:345411
    Linker_histone; linker histone H1 and H5 family
    pfam04774
    Location:69123
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
  5. NM_001285480.2NP_001272409.1  heterochromatin protein 1-binding protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (4) summary
    smart00526
    Location:202268
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:405497
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:106190
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:295361
    Linker_histone; linker histone H1 and H5 family
  6. NM_001285481.2NP_001272410.1  heterochromatin protein 1-binding protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    UniProtKB/TrEMBL
    Z4YKB8
    Conserved Domains (4) summary
    PRK13808
    Location:442541
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:240306
    H15; Domain in histone families 1 and 5
    cd00073
    Location:144228
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:333399
    Linker_histone; linker histone H1 and H5 family
  7. NM_001356431.2NP_001343360.1  heterochromatin protein 1-binding protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (4) summary
    smart00526
    Location:201267
    H15; Domain in histone families 1 and 5
    cd00073
    Location:106190
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:294360
    Linker_histone; linker histone H1 and H5 family
    cl27057
    Location:403502
    ADK; Adenylate kinase
  8. NM_001356432.2NP_001343361.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    Consensus CDS
    CCDS51334.1
    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (5) summary
    PRK13808
    Location:417516
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:24122
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:119203
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308374
    Linker_histone; linker histone H1 and H5 family
  9. NM_001421055.1NP_001407984.1  heterochromatin protein 1-binding protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  10. NM_001421056.1NP_001407985.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  11. NM_001421057.1NP_001407986.1  heterochromatin protein 1-binding protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  12. NM_001421058.1NP_001407987.1  heterochromatin protein 1-binding protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  13. NM_001421059.1NP_001407988.1  heterochromatin protein 1-binding protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  14. NM_001421060.1NP_001407989.1  heterochromatin protein 1-binding protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  15. NM_001421061.1NP_001407990.1  heterochromatin protein 1-binding protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  16. NM_010470.4NP_034600.2  heterochromatin protein 1-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_034600.2

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
    Consensus CDS
    CCDS38927.1
    UniProtKB/Swiss-Prot
    A2AM64, A2AM68, Q3TEA8, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
    UniProtKB/TrEMBL
    Z4YKB8
    Related
    ENSMUSP00000030541.7, ENSMUST00000030541.13
    Conserved Domains (5) summary
    PRK13808
    Location:455554
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:14160
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:157241
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346412
    Linker_histone; linker histone H1 and H5 family

RNA

  1. NR_185235.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  2. NR_185236.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388
  3. NR_185237.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807249, AL929388

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    137943781..137971994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253218.2XP_030109078.1  heterochromatin protein 1-binding protein 3 isoform X5

    UniProtKB/TrEMBL
    Z4YKB8
    Conserved Domains (4) summary
    PRK13808
    Location:442541
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:240306
    H15; Domain in histone families 1 and 5
    cd00073
    Location:144228
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:333399
    Linker_histone; linker histone H1 and H5 family
  2. XM_030253221.2XP_030109081.1  heterochromatin protein 1-binding protein 3 isoform X7

    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (5) summary
    PRK13808
    Location:417516
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:24122
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:119203
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308374
    Linker_histone; linker histone H1 and H5 family
  3. XM_030253217.2XP_030109077.1  heterochromatin protein 1-binding protein 3 isoform X3

    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (4) summary
    PRK13808
    Location:468567
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:266332
    H15; Domain in histone families 1 and 5
    cd00073
    Location:171255
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:359425
    Linker_histone; linker histone H1 and H5 family
  4. XM_036163695.1XP_036019588.1  heterochromatin protein 1-binding protein 3 isoform X9

    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (4) summary
    smart00526
    Location:202268
    H15; Domain in histone families 1 and 5
    PRK14900
    Location:405497
    valS; valyl-tRNA synthetase; Provisional
    cd00073
    Location:106190
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:295361
    Linker_histone; linker histone H1 and H5 family
  5. XM_006538568.5XP_006538631.1  heterochromatin protein 1-binding protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006538631.1

    UniProtKB/Swiss-Prot
    A2AM64, A2AM68, Q3TEA8, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
    UniProtKB/TrEMBL
    Z4YKB8
    Conserved Domains (5) summary
    PRK13808
    Location:455554
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:253319
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:14160
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:157241
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:346412
    Linker_histone; linker histone H1 and H5 family
  6. XM_030253222.2XP_030109082.1  heterochromatin protein 1-binding protein 3 isoform X7

    UniProtKB/TrEMBL
    Z4YKA3
    Conserved Domains (5) summary
    PRK13808
    Location:417516
    PRK13808; adenylate kinase; Provisional
    smart00526
    Location:215281
    H15; Domain in histone families 1 and 5
    PRK13108
    Location:24122
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd00073
    Location:119203
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
    pfam00538
    Location:308374
    Linker_histone; linker histone H1 and H5 family

RNA

  1. XR_003954880.2 RNA Sequence