Hp haptoglobin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpprovided by MGI
Official Full Name: haptoglobinprovided by MGI
Primary source: MGI:MGI:96211
See related: Ensembl:ENSMUSG00000031722 AllianceGenome:MGI:96211
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HP-1; preHP2
Summary: This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]
Expression: Biased expression in liver adult (RPKM 929.2), liver E18 (RPKM 861.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 57.11 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110301760..110305804, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (109575128..109579172, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study.
Title: Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study.
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
Title: Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation.
Title: Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation.
Zscan10 negatively regulates osteoclast differentiation through transcription of Hp.
Title: Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.
Hp plays a protective role against excessive osteoclastogenesis via the Hp-TLR4-IFN-beta axis
Title: Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4-IFN-β Axis.
This study reveals that the presence or absence of Hp exerts important time- and age-dependent influences on intracerebral hemorrhage outcomes
Title: Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.
the levels of trisialylated triantennary glycans of haptoglobin and vitamin D-binding protein increased significantly as liver cancer disease progressed, while the alteration in these protein levels were modest.
Title: Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.
Both immunoblot analyses and enzymelinked immunosorbent assays confirmed the increased concentration of haptoglobin in crude mdx4cv serum. This suggests that haptoglobin, in conjunction with other altered serum proteins, represents a novel diagnostic, prognostic and/or therapymonitoring biomarker candidate to evaluate the inflammatory response in the mdx4cv animal model of dystrophinopathy.
Title: Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.
Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs).
Title: Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model.
the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability
Title: Pharmacogenomic interaction between the Haptoglobin genotype and vitamin E on atherosclerotic plaque progression and stability.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hp (e-PCR), detects polymorphism
- UniSTS:259330

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables hemoglobin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of haptoglobin-hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: haptoglobin

Names: zonulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329965.1 → NP_001316894.1 haptoglobin isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC125162, BY166781
NM_017370.2 → NP_059066.1 haptoglobin isoform 1 preproprotein

See identical proteins and their annotated locations for NP_059066.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC125162, AK152698, M96827

Consensus CDS

CCDS40470.1

UniProtKB/Swiss-Prot

Q61646

UniProtKB/TrEMBL

Q3UBS3

Related

ENSMUSP00000074436.7, ENSMUST00000074898.8

Conserved Domains (3) summary

smart00020
Location:102 → 340

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:103 → 343

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00084
Location:33 → 86

Sushi; Sushi repeat (SCR repeat)