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Hoxd8 homeobox D8 [ Mus musculus (house mouse) ]

Gene ID: 15437, updated on 11-Apr-2024

Summary

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Official Symbol
Hoxd8provided by MGI
Official Full Name
homeobox D8provided by MGI
Primary source
MGI:MGI:96209
See related
Ensembl:ENSMUSG00000027102 AllianceGenome:MGI:96209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-4.3; Hox-5.4; 4921540P06Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; hindlimb bud; limb; and nervous system. Orthologous to human HOXD8 (homeobox D8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 25.2), ovary adult (RPKM 21.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 44.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74534973..74538277)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74704615..74707933)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene homeobox D11 Neighboring gene STARR-seq mESC enhancer starr_04854 Neighboring gene homeobox D10 Neighboring gene homeobox D9 Neighboring gene predicted gene, 38462 Neighboring gene homeobox D3, opposite strand 1 Neighboring gene homeobox D3 Neighboring gene homeobox D4 Neighboring gene microRNA 10b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. Jain K, et al. J Surg Res, 2008 Jul. PMID 18570930
  2. Sequence analysis of the homeobox-containing exon of the murine Hox-4.3 homeogene. Sadoul R, et al. Biochim Biophys Acta, 1991 Jun 13. PMID 1675873
  3. Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Guerreiro I, et al. Elife, 2016 Aug 1. PMID 27476854, Free PMC Article
  4. Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene. Izpisùa-Belmonte JC, et al. Development, 1990 Nov. PMID 1982431
  5. Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken. Hintermann A, et al. Development, 2022 Jun 15. PMID 35770682, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
    Title: HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
  2. Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels.
    Title: Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
  3. Hoxd8 is increased in mid-gestational wounds compared with late-gestational control skin
    Title: Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homeobox protein Hox-D8
Names
homeo box D8
homeobox protein Hox-4.3
homeobox protein Hox-5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290730.2 → NP_001277659.1  homeobox protein Hox-D8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS71077.1
    UniProtKB/TrEMBL
    A2ASN1
    Related
    ENSMUSP00000088094.5, ENSMUST00000074721.6
    Conserved Domains (2) summary
    smart00389
    Location:194 → 250
    HOX; Homeodomain
    COG5576
    Location:139 → 271
    COG5576; Homeodomain-containing transcription factor [Transcription]

  2. NM_001290731.2 → NP_001277660.1  homeobox protein Hox-D8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS79809.1
    UniProtKB/TrEMBL
    F6W963
    Related
    ENSMUSP00000118904.3, ENSMUST00000151380.2
    Conserved Domains (1) summary
    pfam00046
    Location:17 → 69
    Homeobox; Homeobox domain

  3. NM_008276.4 → NP_032302.2  homeobox protein Hox-D8 isoform a

    See identical proteins and their annotated locations for NP_032302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS16143.1
    UniProtKB/Swiss-Prot
    A2ASN2, P23463
    Related
    ENSMUSP00000019749.4, ENSMUST00000019749.4
    Conserved Domains (2) summary
    COG5576
    Location:139 → 272
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:199 → 251
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    74534973..74538277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23463.4 GenPept UniProtKB/Swiss-Prot:P23463

Gene LinkOut

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