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Hoxb8 homeobox B8 [ Mus musculus (house mouse) ]

Gene ID: 15416, updated on 18-Apr-2024

Summary

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Official Symbol
Hoxb8provided by MGI
Official Full Name
homeobox B8provided by MGI
Primary source
MGI:MGI:96189
See related
Ensembl:ENSMUSG00000056648 AllianceGenome:MGI:96189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-2.4
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 49.5), genital fat pad adult (RPKM 24.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 59.82 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96170227..96176151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96279401..96285325)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 196a-1 Neighboring gene predicted gene, 51876 Neighboring gene homeobox B9 Neighboring gene homeobox B7 Neighboring gene STARR-seq mESC enhancer starr_30545 Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeobox B6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion. Tränkner D, et al. Cell Rep, 2019 Oct 22. PMID 31644903, Free PMC Article
  2. Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein. Saul S, et al. J Leukoc Biol, 2019 Nov. PMID 31216372
  3. HoxB8 neutrophils replicate Fcγ receptor and integrin-induced neutrophil signaling and functions. Chu JY, et al. J Leukoc Biol, 2019 Jan. PMID 30211955, Free PMC Article
  4. Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells. Zach F, et al. PLoS One, 2015. PMID 26529319, Free PMC Article
  5. MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Kawasaki H, et al. Nucleic Acids Symp Ser (Oxf), 2004. PMID 17150553

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion.
    Title: A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion.
  2. Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.
    Title: Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.
  3. HoxB8 neutrophils represent a faithful experimental model system for the analysis of Fc and integrin receptor-dependent neutrophil functions.
    Title: HoxB8 neutrophils replicate Fcγ receptor and integrin-induced neutrophil signaling and functions.
  4. CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo.
    Title: CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo.
  5. Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells
    Title: Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells.
  6. results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing.
    Title: Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.
  7. Results show a previously unrecognised link between Hoxb8 expression and microRNAs that provides a new insight into the oncogenic functions of Hoxb8.
    Title: Hoxb8 regulates expression of microRNAs to control cell death and differentiation.
  8. Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal further, transplantation of wild-type bone marrow into Hoxb8 mutant mice rescues their pathological phenotype.
    Title: Hematopoietic origin of pathological grooming in Hoxb8 mutant mice.
  9. A lower number of neurons in the upper spinal laminae and neuronal disorganization in the dorsal horn underlie the sensory defects including the excessive grooming of the Hoxb8 mutant.
    Title: Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
  10. miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb
    Title: The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal spinal cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homeobox protein Hox-B8
Names
homeo box B8
homeobox protein Hox-2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010461.2 → NP_034591.1  homeobox protein Hox-B8

    See identical proteins and their annotated locations for NP_034591.1

    Status: VALIDATED

    Source sequence(s)
    AK083980, AK131612, AL645478
    Consensus CDS
    CCDS25293.1
    UniProtKB/Swiss-Prot
    P09632
    UniProtKB/TrEMBL
    A2A9Z8
    Related
    ENSMUSP00000052496.3, ENSMUST00000052650.4
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96170227..96176151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314295.2 → XP_017169784.1  homeobox protein Hox-B8 isoform X1

    UniProtKB/Swiss-Prot
    P09632
    UniProtKB/TrEMBL
    A2A9Z8
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain

  2. XM_011248758.3 → XP_011247060.1  homeobox protein Hox-B8 isoform X2

    See identical proteins and their annotated locations for XP_011247060.1

    Conserved Domains (1) summary
    pfam00046
    Location:149 → 202
    Homeobox; Homeobox domain

  3. XM_017314296.2 → XP_017169785.1  homeobox protein Hox-B8 isoform X1

    UniProtKB/Swiss-Prot
    P09632
    UniProtKB/TrEMBL
    A2A9Z8
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain

  4. XM_017314297.2 → XP_017169786.1  homeobox protein Hox-B8 isoform X1

    UniProtKB/Swiss-Prot
    P09632
    UniProtKB/TrEMBL
    A2A9Z8
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09632.2 GenPept UniProtKB/Swiss-Prot:P09632

Gene LinkOut

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