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Hnrnpl heterogeneous nuclear ribonucleoprotein L [ Mus musculus (house mouse) ]

Gene ID: 15388, updated on 7-Apr-2024

Summary

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Official Symbol
Hnrnplprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by MGI
Primary source
MGI:MGI:104816
See related
Ensembl:ENSMUSG00000015165 AllianceGenome:MGI:104816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpl; D830027H13Rik
Summary
Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is expressed in several structures, including central nervous system; early conceptus; sensory organ; tail unsegmented mesenchyme; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 136.9), limb E14.5 (RPKM 90.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnpl in Genome Data Viewer
Location:
7 B1; 7 16.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28507971..28521693)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28808546..28822268)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene Ras and Rab interactor-like Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene enoyl coenzyme A hydratase 1, peroxisomal Neighboring gene lectin, galactose binding, soluble 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Peddigari S, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23161687, Free PMC Article
  2. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway. Lv J, et al. J Exp Clin Cancer Res, 2023 Feb 6. PMID 36747239, Free PMC Article
  3. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Li Y, et al. Adv Sci (Weinh), 2021 Jul. PMID 34258149, Free PMC Article
  4. A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting. Ruan X, et al. Cell Rep, 2016 Mar 1. PMID 26904944, Free PMC Article
  5. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells. Li M, et al. Cell Stem Cell, 2015 Jun 4. PMID 25936916, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hnRNPL expression dynamics in the embryo and placenta.
    Title: hnRNPL expression dynamics in the embryo and placenta.
  2. Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
    Title: Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
  3. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
    Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
  4. Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
    Title: Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
  5. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
    Title: HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
  6. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
  7. data suggest that hnRNP L is critical for the survival and functional integrity of HSCs by restricting the activation of caspase-dependent death receptor pathways
    Title: Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.
  8. lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription.
    Title: A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting.
  9. Hnrnpl binds to p53 and inhibits its activation in mouse embryonic stem cells.
    Title: An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells.
  10. Aire-containing complexes include 7SK RNA, the latter interaction disrupted by HNRNPL knockdown, suggesting that HNRNPL may partake in delivering inactive P-TEFb to Aire
    Title: An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402935.1 → NP_001389864.1  heterogeneous nuclear ribonucleoprotein L isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Related
    ENSMUSP00000134734.2, ENSMUST00000174477.8

  2. NM_001402936.1 → NP_001389865.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Conserved Domains (1) summary
    TIGR01649
    Location:1 → 491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  3. NM_001402937.1 → NP_001389866.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Conserved Domains (1) summary
    TIGR01649
    Location:1 → 491
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  4. NM_001402938.1 → NP_001389867.1  heterogeneous nuclear ribonucleoprotein L isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171210
    UniProtKB/TrEMBL
    G3UY38
    Related
    ENSMUSP00000133932.2, ENSMUST00000172529.8

  5. NM_001402939.1 → NP_001389868.1  heterogeneous nuclear ribonucleoprotein L isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171210
    UniProtKB/TrEMBL
    G3UY38

  6. NM_177301.6 → NP_796275.3  heterogeneous nuclear ribonucleoprotein L isoform b

    See identical proteins and their annotated locations for NP_796275.3

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS39864.2
    UniProtKB/Swiss-Prot
    O54789, Q499X2, Q8K0S7, Q8R081
    UniProtKB/TrEMBL
    Q3UMT7
    Related
    ENSMUSP00000133728.2, ENSMUST00000174548.8
    Conserved Domains (1) summary
    TIGR01649
    Location:97 → 584
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. NR_175319.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210

  2. NR_175320.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210
    Related
    ENSMUST00000174882.8

  3. NR_175321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210

  4. NR_175322.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210

  5. NR_175323.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171210

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28507971..28521693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539560.2 → XP_006539623.1  heterogeneous nuclear ribonucleoprotein L isoform X5

    Conserved Domains (1) summary
    TIGR01649
    Location:97 → 291
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  2. XM_036152696.1 → XP_036008589.1  heterogeneous nuclear ribonucleoprotein L isoform X6

    Conserved Domains (1) summary
    TIGR01649
    Location:97 → 292
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. XR_003946390.1 RNA Sequence

  2. XR_004934017.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R081.2 GenPept UniProtKB/Swiss-Prot:Q8R081

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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