Hmmr hyaluronan mediated motility receptor (RHAMM) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmmrprovided by MGI
Official Full Name: hyaluronan mediated motility receptor (RHAMM)provided by MGI
Primary source: MGI:MGI:104667
See related: Ensembl:ENSMUSG00000020330 AllianceGenome:MGI:104667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD168; Rhamm; AA386826
Summary: Predicted to enable hyaluronic acid binding activity. Predicted to be located in centrosome and cytosol. Is expressed in bulbar cushion and testis. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human HMMR (hyaluronan mediated motility receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 10.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A5; 11 24.4 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (40592215..40624290, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (40701388..40733464, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell transcriptomic analysis identifies a highly replicating Cd168[+] skeletal stem/progenitor cell population in mouse long bones.
Title: Single-cell transcriptomic analysis identifies a highly replicating Cd168(+) skeletal stem/progenitor cell population in mouse long bones.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Title: HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Oleate acid-stimulated HMMR expression by CEBPalpha is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
Title: Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer.
Title: High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer.
Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.
Title: Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.
Study provides evidence that RHAMM is a critical component of the inflammatory response, respiratory distress and fibrosis after acute lung injury.
Title: The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury.
Results showed, for the first time, the distribution and activity of RHAMM in the context of skeletal muscle, and established that CD44 and RHAMM activation promote myogenic and connective tissue migration and proliferation.
Title: Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis.
These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development.
Title: HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
RHAMM localises at the mitotic spindle of ovarian granulosa cells via its C-terminus, deletion of which impairs proper spindle orientation and folliculogenesis.
Title: RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility.
RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
Title: The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

18.MMHAP76FRF9.seq (e-PCR)
- UniSTS:123397

UniSTS:236554 (e-PCR)
- UniSTS:236554

Hmmr (e-PCR), detects polymorphism
- UniSTS:143354

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan mediated motility receptor

Names: intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013552.2 → NP_038580.2 hyaluronan mediated motility receptor

See identical proteins and their annotated locations for NP_038580.2

Status: VALIDATED

Source sequence(s)

AF031932, AK143123, AL646055, CN455388

Consensus CDS

CCDS24548.1

UniProtKB/Swiss-Prot

Q00547, Q5NC88

UniProtKB/TrEMBL

Q8VDR2

Related

ENSMUSP00000020579.8, ENSMUST00000020579.9

Conserved Domains (3) summary

pfam15905
Location:16 → 338

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:636 → 789

HMMR_C; Hyaluronan mediated motility receptor C-terminal

cl19219
Location:277 → 431

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

40592215..40624290 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156344.1 → XP_036012237.1 hyaluronan mediated motility receptor isoform X1

UniProtKB/TrEMBL

Q8VDR2

Conserved Domains (3) summary

PRK02224
Location:104 → 575

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam15905
Location:16 → 337

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:635 → 788

HMMR_C; Hyaluronan mediated motility receptor C-terminal
XM_006532279.4 → XP_006532342.1 hyaluronan mediated motility receptor isoform X4

Conserved Domains (3) summary

PRK02224
Location:38 → 541

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam15905
Location:1 → 154

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:431 → 584

HMMR_C; Hyaluronan mediated motility receptor C-terminal
XM_006532278.4 → XP_006532341.1 hyaluronan mediated motility receptor isoform X3

Conserved Domains (3) summary

TIGR02168
Location:191 → 472

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15905
Location:1 → 154

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:452 → 605

HMMR_C; Hyaluronan mediated motility receptor C-terminal
XM_006532276.5 → XP_006532339.1 hyaluronan mediated motility receptor isoform X2

UniProtKB/TrEMBL

Q8VDR2

Conserved Domains (3) summary

PRK02224
Location:222 → 731

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam15905
Location:16 → 338

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:615 → 768

HMMR_C; Hyaluronan mediated motility receptor C-terminal