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TTC23L tetratricopeptide repeat domain 23 like [ Homo sapiens (human) ]

Gene ID: 153657, updated on 3-Apr-2024

Summary

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Official Symbol
TTC23Lprovided by HGNC
Official Full Name
tetratricopeptide repeat domain 23 likeprovided by HGNC
Primary source
HGNC:HGNC:26355
See related
Ensembl:ENSG00000205838 MIM:616344; AllianceGenome:HGNC:26355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC25-1
Summary
Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 3.3), adrenal (RPKM 0.3) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
5p13.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (34839164..34925682)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (35086287..35172714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34839269..34925787)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15966 Neighboring gene RAI14 divergent transcript Neighboring gene retinoic acid induced 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34700297-34700798 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34700799-34701298 Neighboring gene uncharacterized LOC124900960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34721500-34722000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34722001-34722501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:34735806-34736306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:34736307-34736807 Neighboring gene NANOG hESC enhancer GRCh37_chr5:34736814-34737353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22465 Neighboring gene MPRA-validated peak5222 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22466 Neighboring gene uncharacterized LOC124900959 Neighboring gene TTC23L antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:34866693-34867892 Neighboring gene ribosomal protein L21 pseudogene 54 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:34915193-34915798 and GRCh37_chr5:34915799-34916404 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:34922818-34924017 Neighboring gene uncharacterized LOC124900961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:34930148-34930793 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene biogenesis of ribosomes BRX1 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:34955801-34955974 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22470 Neighboring gene alanine--glyoxylate aminotransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. Pan TL, et al. Cell Cycle, 2015. PMID 25751302, Free PMC Article
  2. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Simonis N, et al. Retrovirology, 2012 Mar 29. PMID 22458338, Free PMC Article
  3. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. Martínez-Noël G, et al. J Mol Biol, 2018 Mar 30. PMID 29426014, Free PMC Article
  4. A proteome-scale map of the SARS-CoV-2-human contactome. Kim DK, et al. Nat Biotechnol, 2023 Jan. PMID 36217029, Free PMC Article
  5. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLJ25439 is involved in pathways related to anti-apoptosis, protein folding, the cell cycle, and cytoskeleton regulation.
    Title: FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tetratricopeptide repeat domain 23-like (TTC23L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25439

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to endoplasmic reticulum stress NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 23-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317949.2 → NP_001304878.1  tetratricopeptide repeat protein 23-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026801, JN799997
    UniProtKB/TrEMBL
    A0A1W2PP54
    Conserved Domains (1) summary
    pfam13424
    Location:262 → 341
    TPR_12; Tetratricopeptide repeat

  2. NM_001386169.1 → NP_001373098.1  tetratricopeptide repeat protein 23-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026801
    UniProtKB/TrEMBL
    A0A1W2PP54
    Related
    ENSP00000491000.1, ENST00000638320.2

  3. NM_001386170.1 → NP_001373099.1  tetratricopeptide repeat protein 23-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC026801
    UniProtKB/TrEMBL
    A0A1W2PP54

  4. NM_001386171.1 → NP_001373100.1  tetratricopeptide repeat protein 23-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC026801
    UniProtKB/TrEMBL
    A0A1W2PP54

  5. NM_001386172.1 → NP_001373101.1  tetratricopeptide repeat protein 23-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026801
    Consensus CDS
    CCDS54840.1
    UniProtKB/Swiss-Prot
    G8IJH6, Q6PF05, Q6RGS4, Q8N7R3, Q96LJ2
    UniProtKB/TrEMBL
    A0A1W2PP54
    Related
    ENSP00000513788.1, ENST00000698543.1

  6. NM_144725.4 → NP_653326.3  tetratricopeptide repeat protein 23-like isoform 2

    See identical proteins and their annotated locations for NP_653326.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start site, and contains a shorter 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC026801, AK058168, BC057775, BX088767
    Consensus CDS
    CCDS54840.1
    UniProtKB/Swiss-Prot
    G8IJH6, Q6PF05, Q6RGS4, Q8N7R3, Q96LJ2
    UniProtKB/TrEMBL
    A0A1W2PP54
    Related
    ENSP00000422188.1, ENST00000505624.6
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

RNA

  1. NR_169874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801

  2. NR_169875.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801

  3. NR_169876.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    34839164..34925682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416824.1 → XP_047272780.1  tetratricopeptide repeat protein 23-like isoform X1

    UniProtKB/TrEMBL
    A0A3B3IS63

  2. XM_017009120.3 → XP_016864609.1  tetratricopeptide repeat protein 23-like isoform X1

    UniProtKB/TrEMBL
    A0A1W2PP54, A0A3B3IS63
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

  3. XM_011513984.4 → XP_011512286.1  tetratricopeptide repeat protein 23-like isoform X1

    UniProtKB/TrEMBL
    A0A1W2PP54, A0A3B3IS63
    Related
    ENSP00000497109.1, ENST00000514080.2
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

  4. XM_011513985.3 → XP_011512287.1  tetratricopeptide repeat protein 23-like isoform X3

    UniProtKB/TrEMBL
    A0A1W2PP54
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

  5. XM_017009123.3 → XP_016864612.1  tetratricopeptide repeat protein 23-like isoform X4

    UniProtKB/TrEMBL
    A0A1W2PP54

  6. XM_047416826.1 → XP_047272782.1  tetratricopeptide repeat protein 23-like isoform X6

  7. XM_011513987.4 → XP_011512289.1  tetratricopeptide repeat protein 23-like isoform X6

    Related
    ENSP00000484792.1, ENST00000610313.1

  8. XM_017009121.3 → XP_016864610.1  tetratricopeptide repeat protein 23-like isoform X1

    UniProtKB/TrEMBL
    A0A1W2PP54, A0A3B3IS63
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

  9. XM_017009119.3 → XP_016864608.1  tetratricopeptide repeat protein 23-like isoform X2

    UniProtKB/TrEMBL
    A0A1W2PP54

  10. XM_017009124.3 → XP_016864613.1  tetratricopeptide repeat protein 23-like isoform X5

  11. XM_017009122.3 → XP_016864611.1  tetratricopeptide repeat protein 23-like isoform X1

    UniProtKB/TrEMBL
    A0A1W2PP54, A0A3B3IS63
    Conserved Domains (1) summary
    pfam13424
    Location:253 → 332
    TPR_12; Tetratricopeptide repeat

  12. XM_017009126.3 → XP_016864615.1  tetratricopeptide repeat protein 23-like isoform X8

  13. XM_047416825.1 → XP_047272781.1  tetratricopeptide repeat protein 23-like isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    35086287..35172714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351826.1 → XP_054207801.1  tetratricopeptide repeat protein 23-like isoform X1

  2. XM_054351823.1 → XP_054207798.1  tetratricopeptide repeat protein 23-like isoform X1

  3. XM_054351824.1 → XP_054207799.1  tetratricopeptide repeat protein 23-like isoform X1

  4. XM_054351829.1 → XP_054207804.1  tetratricopeptide repeat protein 23-like isoform X3

  5. XM_054351830.1 → XP_054207805.1  tetratricopeptide repeat protein 23-like isoform X4

  6. XM_054351834.1 → XP_054207809.1  tetratricopeptide repeat protein 23-like isoform X6

  7. XM_054351832.1 → XP_054207807.1  tetratricopeptide repeat protein 23-like isoform X6

  8. XM_054351827.1 → XP_054207802.1  tetratricopeptide repeat protein 23-like isoform X1

  9. XM_054351825.1 → XP_054207800.1  tetratricopeptide repeat protein 23-like isoform X2

  10. XM_054351831.1 → XP_054207806.1  tetratricopeptide repeat protein 23-like isoform X5

  11. XM_054351833.1 → XP_054207808.1  tetratricopeptide repeat protein 23-like isoform X7

  12. XM_054351835.1 → XP_054207810.1  tetratricopeptide repeat protein 23-like isoform X8

  13. XM_054351828.1 → XP_054207803.1  tetratricopeptide repeat protein 23-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PF05.2 GenPept UniProtKB/Swiss-Prot:Q6PF05

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