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SPMIP2 sperm microtubule inner protein 2 [ Homo sapiens (human) ]

Gene ID: 152940, updated on 5-Mar-2024

Summary

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Official Symbol
SPMIP2provided by HGNC
Official Full Name
sperm microtubule inner protein 2provided by HGNC
Primary source
HGNC:HGNC:26342
See related
Ensembl:ENSG00000164123 AllianceGenome:HGNC:26342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf45
Expression
Restricted expression toward testis (RPKM 3.4) See more
Orthologs
mouse all
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Genomic context

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Location:
4q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158893134..159082885, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (162243906..162433698, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159814286..159956381, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr4:159643958-159644541 and GRCh37_chr4:159644542-159645126 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:159690086-159690823 Neighboring gene peptidylprolyl isomerase D Neighboring gene Sharpr-MPRA regulatory region 12747 Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:159766516-159767164 Neighboring gene folliculin interacting protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159802306-159803286 Neighboring gene Sharpr-MPRA regulatory region 14183 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823055-159823920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823921-159824786 Neighboring gene uncharacterized LOC124900178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:159917411-159918610 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:159927373-159927905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22088 Neighboring gene proteasome activator subunit 2 pseudogene 3 Neighboring gene fatty acid binding protein 5 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 3178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15775 Neighboring gene Sharpr-MPRA regulatory region 13777 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:160023381-160024072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15777 Neighboring gene Sharpr-MPRA regulatory region 8742 Neighboring gene Rap guanine nucleotide exchange factor 2 Neighboring gene microRNA 3688-1 Neighboring gene microRNA 3688-2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22091 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:160096538-160097270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22092 Neighboring gene Sharpr-MPRA regulatory region 9369 Neighboring gene Sharpr-MPRA regulatory region 10828 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:160304254-160304828 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:160304829-160305402 Neighboring gene MPRA-validated peak5139 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:160322475-160323674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15778 Neighboring gene uncharacterized LOC124900924

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural specializations of the sperm tail. Leung MR, et al. Cell, 2023 Jun 22. PMID 37327785, Free PMC Article
  2. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein SPMIP2
Names
sperm associated microtubule inner protein 2
uncharacterized protein C4orf45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152543.3 → NP_689756.2  protein SPMIP2

    See identical proteins and their annotated locations for NP_689756.2

    Status: VALIDATED

    Source sequence(s)
    AC093700, AC109823, BP369394, DB037602
    Consensus CDS
    CCDS47156.1
    UniProtKB/Swiss-Prot
    A8MPU3, C9J0T8, Q96LM5
    Related
    ENSP00000412215.2, ENST00000434826.3
    Conserved Domains (1) summary
    pfam15123
    Location:22 → 133
    DUF4562; Domain of unknown function (DUF4562)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    158893134..159082885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531671.3 → XP_011529973.1  protein SPMIP2 isoform X2

    See identical proteins and their annotated locations for XP_011529973.1

    Conserved Domains (1) summary
    pfam15123
    Location:15 → 126
    DUF4562; Domain of unknown function (DUF4562)

  2. XM_011531672.4 → XP_011529974.1  protein SPMIP2 isoform X2

    See identical proteins and their annotated locations for XP_011529974.1

    Conserved Domains (1) summary
    pfam15123
    Location:15 → 126
    DUF4562; Domain of unknown function (DUF4562)

  3. XM_047449676.1 → XP_047305632.1  protein SPMIP2 isoform X1

    UniProtKB/Swiss-Prot
    A8MPU3, C9J0T8, Q96LM5

  4. XM_017007809.2 → XP_016863298.1  protein SPMIP2 isoform X1

    UniProtKB/Swiss-Prot
    A8MPU3, C9J0T8, Q96LM5
    Conserved Domains (1) summary
    pfam15123
    Location:22 → 133
    DUF4562; Domain of unknown function (DUF4562)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    162243906..162433698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349053.1 → XP_054205028.1  protein SPMIP2 isoform X2

  2. XM_054349051.1 → XP_054205026.1  protein SPMIP2 isoform X1

  3. XM_054349054.1 → XP_054205029.1  protein SPMIP2 isoform X2

  4. XM_054349052.1 → XP_054205027.1  protein SPMIP2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LM5.3 GenPept UniProtKB/Swiss-Prot:Q96LM5

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