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CNTN4 contactin 4 [ Homo sapiens (human) ]

Gene ID: 152330, updated on 3-Apr-2024

Summary

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Official Symbol
CNTN4provided by HGNC
Official Full Name
contactin 4provided by HGNC
Primary source
HGNC:HGNC:2174
See related
Ensembl:ENSG00000144619 MIM:607280; AllianceGenome:HGNC:2174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXCAM; BIG-2
Summary
This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Expression
Broad expression in endometrium (RPKM 2.7), thyroid (RPKM 2.4) and 21 other tissues See more
Orthologs
all
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Genomic context

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Location:
3p26.3-p26.2
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (2098866..3057959)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (2092772..3052283)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (2140550..3099643)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr3:2136506-2137113 Neighboring gene uncharacterized LOC124909338 Neighboring gene RN7SK pseudogene 144 Neighboring gene CNTN4 antisense RNA 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68491 Neighboring gene meiotic recombination hotspot T Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68954 Neighboring gene histidine triad nucleotide binding protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19336 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:2806697-2807249 Neighboring gene NANOG hESC enhancer GRCh37_chr3:2812162-2812685 Neighboring gene uncharacterized LOC105376926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19340 Neighboring gene MPRA-validated peak4526 silencer Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69430 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:3079797-3080996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19342 Neighboring gene CNTN4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19343 Neighboring gene uncharacterized LOC124909339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14009 Neighboring gene interleukin 5 receptor subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders. D'Abate L, et al. Nat Commun, 2019 Dec 5. PMID 31801954, Free PMC Article
  2. Intragenic CNTN4 copy number variants associated with a spectrum of neurobehavioral phenotypes. Zhang SQ, et al. Eur J Med Genet, 2020 Mar. PMID 31422286
  3. Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas. Evenepoel L, et al. J Clin Endocrinol Metab, 2018 Jan 1. PMID 28938490
  4. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Liu M, et al. Psychol Med, 2017 Apr. PMID 27995817, Free PMC Article
  5. Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use. Clark SL, et al. Alcohol Clin Exp Res, 2015 Aug. PMID 26146898, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPARGC1B and CNTN4 genotypes are associated with elevated thromboxane A2 formation and with an excess of cardiovascular events. Aspirin appears to blunt these associations.
    Title: Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A(2) formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
  2. High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas.
    Title: Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.
  3. Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia.
    Title: Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
  4. SNPs within the CNTN4 gene are associated with increased risk of oral cancer.
    Title: Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer.
  5. SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans
    Title: GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.
  6. By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use.
    Title: Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.
  7. data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization
    Title: Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.
  8. We identified CNTN4 as a novel candidate gene for POAG.
    Title: Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.
  9. these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations.
    Title: Disruption of Contactin 4 in two subjects with autism in Chinese population.
  10. Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism.
    Title: Contactin 4 as an autism susceptibility locus.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2022-06-14)

ClinGen Genome Curation Page
Haploinsufficency

No evidence available (Last evaluated 2022-06-14)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.
EBI GWAS Catalog
A genome-wide association study of acenocoumarol maintenance dosage.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
EBI GWAS Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.
EBI GWAS Catalog
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
EBI GWAS Catalog
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
EBI GWAS Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
EBI GWAS Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance TAS
Traceable Author Statement
more info
 PubMed 
involved_in axonal fasciculation TAS
Traceable Author Statement
more info
 PubMed 
involved_in axonogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron cell-cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic plasticity TAS
Traceable Author Statement
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
contactin-4
Names
axonal-associated cell adhesion molecule
brain-derived immunoglobulin superfamily protein 2
neural cell adhesion protein BIG-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012827.2 RefSeqGene

    Range
    3304..962397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206955.2 → NP_001193884.1  contactin-4 isoform a precursor

    See identical proteins and their annotated locations for NP_001193884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).
    Source sequence(s)
    AC022002, AC024057, AF549455, R42166
    Consensus CDS
    CCDS43041.1
    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Related
    ENSP00000380602.1, ENST00000397461.5
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  2. NM_001206956.2 → NP_001193885.1  contactin-4 isoform d

    See identical proteins and their annotated locations for NP_001193885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC022002, BC026119, DB457029, R42166
    UniProtKB/TrEMBL
    B3KQ34
    Conserved Domains (2) summary
    cd00063
    Location:268 → 361
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:185 → 268
    Ig; Immunoglobulin domain

  3. NM_001350095.2 → NP_001337024.1  contactin-4 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).
    Source sequence(s)
    AC022002, AK125460, AY090737, BM718335, CD697898, CN282428, DN991363, R42166
    Consensus CDS
    CCDS43041.1
    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  4. NM_175607.3 → NP_783200.1  contactin-4 isoform a precursor

    See identical proteins and their annotated locations for NP_783200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 4 and 6 encode the same isoform (a).
    Source sequence(s)
    AC022002, AF464063, AF549455, AY090737, DA063654, DA796385, R42166
    Consensus CDS
    CCDS43041.1
    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Related
    ENSP00000396010.1, ENST00000418658.6
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  5. NM_175613.3 → NP_783302.1  contactin-4 isoform c

    See identical proteins and their annotated locations for NP_783302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC022002, AK314396, DB457029, R42166
    Consensus CDS
    CCDS2558.1
    UniProtKB/TrEMBL
    B3KQ34
    Related
    ENSP00000380600.2, ENST00000397459.6
    Conserved Domains (5) summary
    cd04969
    Location:94 → 166
    Ig5_Contactin_like; Fifth Ig domain of contactin
    cd05853
    Location:185 → 269
    Ig6_Contactin-4; Sixth Ig domain of contactin-4
    smart00410
    Location:87 → 166
    IG_like; Immunoglobulin like
    cd00063
    Location:269 → 362
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:4 → 73
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    2098866..3057959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005783.2 → XP_016861272.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  2. XM_047447536.1 → XP_047303492.1  contactin-4 isoform X2

  3. XM_011533427.3 → XP_011531729.1  contactin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531729.1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  4. XM_017005785.2 → XP_016861274.1  contactin-4 isoform X2

    Conserved Domains (5) summary
    cd04969
    Location:422 → 494
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00410
    Location:415 → 494
    IG_like; Immunoglobulin like
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:26 → 117
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:513 → 596
    Ig; Immunoglobulin domain

  5. XM_017005782.2 → XP_016861271.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  6. XM_011533425.4 → XP_011531727.1  contactin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531727.1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  7. XM_006713004.5 → XP_006713067.1  contactin-4 isoform X2

    Conserved Domains (5) summary
    cd04969
    Location:422 → 494
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00410
    Location:415 → 494
    IG_like; Immunoglobulin like
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:26 → 117
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:513 → 596
    Ig; Immunoglobulin domain

  8. XM_017005784.3 → XP_016861273.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  9. XM_047447535.1 → XP_047303491.1  contactin-4 isoform X2

  10. XM_047447518.1 → XP_047303474.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  11. XM_047447523.1 → XP_047303479.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  12. XM_047447528.1 → XP_047303484.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  13. XM_047447521.1 → XP_047303477.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  14. XM_047447520.1 → XP_047303476.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  15. XM_047447526.1 → XP_047303482.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  16. XM_047447525.1 → XP_047303481.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  17. XM_047447529.1 → XP_047303485.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  18. XM_047447522.1 → XP_047303478.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  19. XM_047447530.1 → XP_047303486.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  20. XM_047447532.1 → XP_047303488.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  21. XM_047447517.1 → XP_047303473.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  22. XM_047447524.1 → XP_047303480.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  23. XM_047447531.1 → XP_047303487.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  24. XM_047447533.1 → XP_047303489.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  25. XM_047447519.1 → XP_047303475.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  26. XM_047447527.1 → XP_047303483.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  27. XM_047447516.1 → XP_047303472.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  28. XM_047447534.1 → XP_047303490.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  29. XM_011533430.3 → XP_011531732.1  contactin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531732.1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  30. XM_017005787.2 → XP_016861276.1  contactin-4 isoform X2

    Conserved Domains (5) summary
    cd04969
    Location:422 → 494
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00410
    Location:415 → 494
    IG_like; Immunoglobulin like
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:26 → 117
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:513 → 596
    Ig; Immunoglobulin domain

  31. XM_011533428.3 → XP_011531730.1  contactin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531730.1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Related
    ENSP00000413642.1, ENST00000427331.5
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  32. XM_017005786.2 → XP_016861275.1  contactin-4 isoform X2

    Conserved Domains (5) summary
    cd04969
    Location:422 → 494
    Ig5_Contactin_like; Fifth Ig domain of contactin
    smart00410
    Location:415 → 494
    IG_like; Immunoglobulin like
    cd00063
    Location:596 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:26 → 117
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:513 → 596
    Ig; Immunoglobulin domain

  33. XM_011533429.3 → XP_011531731.1  contactin-4 isoform X1

    See identical proteins and their annotated locations for XP_011531731.1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35
    Conserved Domains (4) summary
    cd05853
    Location:513 → 597
    Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
    cd00063
    Location:597 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd04969
    Location:422 → 494
    Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
    cl11960
    Location:225 → 313
    Ig; Immunoglobulin domain

  34. XM_011533431.3 → XP_011531733.1  contactin-4 isoform X3

    Conserved Domains (6) summary
    cd04969
    Location:411 → 483
    Ig5_Contactin_like; Fifth Ig domain of contactin
    cd05853
    Location:502 → 586
    Ig6_Contactin-4; Sixth Ig domain of contactin-4
    smart00410
    Location:404 → 483
    IG_like; Immunoglobulin like
    cd00063
    Location:586 → 679
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:15 → 106
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:214 → 302
    Ig; Immunoglobulin domain

  35. XM_047447537.1 → XP_047303493.1  contactin-4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    2092772..3052283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345401.1 → XP_054201376.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  2. XM_054345417.1 → XP_054201392.1  contactin-4 isoform X2

  3. XM_054345402.1 → XP_054201377.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  4. XM_054345416.1 → XP_054201391.1  contactin-4 isoform X2

  5. XM_054345400.1 → XP_054201375.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  6. XM_054345399.1 → XP_054201374.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  7. XM_054345420.1 → XP_054201395.1  contactin-4 isoform X2

  8. XM_054345406.1 → XP_054201381.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  9. XM_054345410.1 → XP_054201385.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  10. XM_054345412.1 → XP_054201387.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  11. XM_054345413.1 → XP_054201388.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  12. XM_054345407.1 → XP_054201382.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  13. XM_054345409.1 → XP_054201384.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  14. XM_054345408.1 → XP_054201383.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  15. XM_054345411.1 → XP_054201386.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  16. XM_054345405.1 → XP_054201380.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  17. XM_054345414.1 → XP_054201389.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  18. XM_054345423.1 → XP_054201398.1  contactin-4 isoform X5

  19. XM_054345404.1 → XP_054201379.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  20. XM_054345419.1 → XP_054201394.1  contactin-4 isoform X2

  21. XM_054345403.1 → XP_054201378.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  22. XM_054345418.1 → XP_054201393.1  contactin-4 isoform X2

  23. XM_054345415.1 → XP_054201390.1  contactin-4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAX3, Q8IWV2, Q8IX14, Q8TC35

  24. XM_054345421.1 → XP_054201396.1  contactin-4 isoform X3

  25. XM_054345422.1 → XP_054201397.1  contactin-4 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175612.1: Suppressed sequence

    Description
    NM_175612.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWV2.1 GenPept UniProtKB/Swiss-Prot:Q8IWV2

Gene LinkOut

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