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Hes2 hes family bHLH transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 15206, updated on 18-Apr-2024

Summary

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Official Symbol
Hes2provided by MGI
Official Full Name
hes family bHLH transcription factor 2provided by MGI
Primary source
MGI:MGI:1098624
See related
Ensembl:ENSMUSG00000028940 AllianceGenome:MGI:1098624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HES-2
Summary
The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Biased expression in duodenum adult (RPKM 4.4), small intestine adult (RPKM 3.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 82.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152243324..152246926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152158867..152162469)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene espin-like pseudogene Neighboring gene espin Neighboring gene STARR-positive B cell enhancer ABC_E10294 Neighboring gene STARR-positive B cell enhancer ABC_E4735 Neighboring gene STARR-seq mESC enhancer starr_12198 Neighboring gene predicted gene 13077 Neighboring gene predicted gene, 30622 Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene STARR-positive B cell enhancer ABC_E9627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. Ishibashi M, et al. Eur J Biochem, 1993 Aug 1. PMID 8354270
  2. A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gong TW, et al. Gene, 1999 Oct 18. PMID 10571041
  3. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Nishimura M, et al. Genomics, 1998 Apr 1. PMID 9570950
  4. Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Herranz M, et al. Cancer Res, 1999 May 1. PMID 10232589
  5. Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4. Jackson T, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207892

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor HES-2
Names
hairy and enhancer of split 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301805.1 → NP_001288734.1  transcription factor HES-2

    See identical proteins and their annotated locations for NP_001288734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053792, AL772240, BC138112
    Consensus CDS
    CCDS18995.1
    UniProtKB/Swiss-Prot
    O54792, Q8BKA6
    Conserved Domains (2) summary
    smart00511
    Location:85 → 123
    ORANGE; Orange domain
    cl00081
    Location:10 → 73
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. NM_008236.4 → NP_032262.2  transcription factor HES-2

    See identical proteins and their annotated locations for NP_032262.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL772240
    Consensus CDS
    CCDS18995.1
    UniProtKB/Swiss-Prot
    O54792, Q8BKA6
    Related
    ENSMUSP00000030782.2, ENSMUST00000030782.2
    Conserved Domains (2) summary
    smart00511
    Location:85 → 123
    ORANGE; Orange domain
    cl00081
    Location:10 → 73
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152243324..152246926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319982.2 → XP_017175471.1  transcription factor HES-2 isoform X1

    UniProtKB/Swiss-Prot
    O54792, Q8BKA6
    Conserved Domains (2) summary
    smart00511
    Location:85 → 123
    ORANGE; Orange domain
    cl00081
    Location:10 → 73
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54792.2 GenPept UniProtKB/Swiss-Prot:O54792

Gene LinkOut

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