Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hba-xprovided by MGI
Official Full Name: hemoglobin X, alpha-like embryonic chain in Hba complexprovided by MGI
Primary source: MGI:MGI:96019
See related: Ensembl:ENSMUSG00000055609 AllianceGenome:MGI:96019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hbz
Summary: Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within erythrocyte maturation and negative regulation of transcription by RNA polymerase II. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including alimentary system; dorsal aorta; extraembryonic component; liver; and placenta. Orthologous to human HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 2628.2) and CNS E11.5 (RPKM 744.9) See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 18.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (32226600..32228116)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (32276600..32278116)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chimeric zeta globin exhibits oxygen binding characteristics which fall within the range observed in the adult mouse hemoglobin.
Title: The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function.
mutant displays an alpha-thalassemia-like syndrome, modifying loci affect the penetrance of embryonic lethality
Title: zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hba-x (e-PCR), detects polymorphism
- UniSTS:531472

Hba-x (e-PCR), detects polymorphism
- UniSTS:259179

D11Mit53 (e-PCR), detects polymorphism
- UniSTS:126600

Hba-x (e-PCR), detects polymorphism
- UniSTS:516508

Hba-x (e-PCR), detects polymorphism
- UniSTS:516522

AI450015 (e-PCR)
- UniSTS:180170

Hba-x (e-PCR), detects polymorphism
- UniSTS:143320

Hba-x (e-PCR), detects polymorphism
- UniSTS:143321

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within erythrocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxygen transport	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of hemoglobin complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit zeta

Names: alpha-like embryonic globin chain x; hemaglobin zeta; hemoglobin zeta chain; zeta-globin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.