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Has3 hyaluronan synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 15118, updated on 21-Apr-2024

Summary

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Official Symbol
Has3provided by MGI
Official Full Name
hyaluronan synthase 3provided by MGI
Primary source
MGI:MGI:109599
See related
Ensembl:ENSMUSG00000031910 AllianceGenome:MGI:109599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables hyaluronan synthase activity. Involved in extracellular matrix assembly and extracellular polysaccharide biosynthetic process. Acts upstream of or within hyaluronan biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; skin; and urinary system. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107596874..107609534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106870242..106882902)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22570 Neighboring gene cadherin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109171364-109171664 Neighboring gene transport and golgi organization 6 Neighboring gene STARR-seq mESC enhancer starr_22578 Neighboring gene STARR-positive B cell enhancer ABC_E10521 Neighboring gene STARR-seq mESC enhancer starr_22579 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109344486-109344787 Neighboring gene predicted gene, 34197 Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene UTP4 small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. Mayer CA, et al. Pediatr Res, 2022 Sep. PMID 34750521, Free PMC Article
  2. SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis. Hartmann F, et al. Circ Res, 2021 Nov 12. PMID 34615369, Free PMC Article
  3. Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. Kiene LS, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26586662, Free PMC Article
  4. Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions. Rilla K, et al. J Histochem Cytochem, 2008 Oct. PMID 18574248, Free PMC Article
  5. Hyaluronan synthesis induces microvillus-like cell surface protrusions. Kultti A, et al. J Biol Chem, 2006 Jun 9. PMID 16595683

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.
    Title: CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.
  2. Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
    Title: Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
  3. SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
    Title: SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
  4. hyaluronan metabolism via HAS3 does not markedly influence the extracellular matrix structure or function of the Achilles tendon body
    Title: Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa.
  5. These gene expression patterns suggested that Has3 is the main control factor for prenatal and postnatal HA synthesis of the tooth germ, and may in part regulate crown and root formation of the tooth germ, maintenance of stem cell niches in the apical bud as well as mineral transport in PL.
    Title: An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.
  6. HAS3-mediated HA synthesis after vessel injury supports seminal signaling pathways in activation of VSMC, increases platelet-derived growth factor BB-mediated migration, and in turn enhances neointimal hyperplasia in vivo.
    Title: Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.
  7. This study demonstrates that the ablation of Has3-dependent HA causes reduced ECS volume in the CA1 stratum pyramidale, epileptiform activity in the CA1 region, and epileptic seizures in the mutant mouse.
    Title: Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.
  8. Selective loss of Has1 and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
    Title: Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.
  9. proper regulation of the expression of each HAS isoform is required for optimal malignant transformation and tumor growth
    Title: Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.
  10. expression in the developing teeth, vibrissae hair follicles, nasal cavity, and inner ear
    Title: Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronan synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyaluronan synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extracellular polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular polysaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in hyaluranon cable ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hyaluronan synthase 3
Names
HA synthase 3
hyaluronate synthase 3
hyaluronic acid synthase 3
NP_001317977.1
NP_032243.2
XP_006530763.1
XP_006530764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331048.1 → NP_001317977.1  hyaluronan synthase 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC123864, AK028582
    Consensus CDS
    CCDS22640.1
    UniProtKB/Swiss-Prot
    O08650, Q8CEB9
    UniProtKB/TrEMBL
    B2RR08
    Related
    ENSMUSP00000135303.2, ENSMUST00000176144.8
    Conserved Domains (2) summary
    cd06434
    Location:87 → 365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403 → 493
    DUF805; Protein of unknown function (DUF805)

  2. NM_008217.4 → NP_032243.2  hyaluronan synthase 3

    See identical proteins and their annotated locations for NP_032243.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140328, AK028582, BY132822
    Consensus CDS
    CCDS22640.1
    UniProtKB/Swiss-Prot
    O08650, Q8CEB9
    UniProtKB/TrEMBL
    B2RR08
    Related
    ENSMUSP00000034385.6, ENSMUST00000034385.12
    Conserved Domains (2) summary
    cd06434
    Location:87 → 365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403 → 493
    DUF805; Protein of unknown function (DUF805)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107596874..107609534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530701.4 → XP_006530764.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_006530764.1

    UniProtKB/Swiss-Prot
    O08650, Q8CEB9
    UniProtKB/TrEMBL
    B2RR08
    Conserved Domains (2) summary
    cd06434
    Location:87 → 365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403 → 493
    DUF805; Protein of unknown function (DUF805)

  2. XM_006530700.4 → XP_006530763.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_006530763.1

    UniProtKB/Swiss-Prot
    O08650, Q8CEB9
    UniProtKB/TrEMBL
    B2RR08
    Conserved Domains (2) summary
    cd06434
    Location:87 → 365
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    cl01224
    Location:403 → 493
    DUF805; Protein of unknown function (DUF805)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08650.2 GenPept UniProtKB/Swiss-Prot:O08650

Gene LinkOut

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