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Hao1 hydroxyacid oxidase 1, liver [ Mus musculus (house mouse) ]

Gene ID: 15112, updated on 5-Mar-2024

Summary

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Official Symbol
Hao1provided by MGI
Official Full Name
hydroxyacid oxidase 1, liverprovided by MGI
Primary source
MGI:MGI:96011
See related
Ensembl:ENSMUSG00000027261 AllianceGenome:MGI:96011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GOX; Gox1; Hao-1
Summary
Enables (S)-2-hydroxy-acid oxidase activity. Predicted to be involved in fatty acid alpha-oxidation and glycolate catabolic process. Located in peroxisome. Is expressed in alimentary system; gland; liver; and pancreas. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 32.6) and liver adult (RPKM 18.0) See more
Orthologs
human all
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Genomic context

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See Hao1 in Genome Data Viewer
Location:
2 F2; 2 65.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (134339281..134396272, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (134497361..134554352, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39940 Neighboring gene STARR-seq mESC enhancer starr_05765 Neighboring gene STARR-seq mESC enhancer starr_05766 Neighboring gene STARR-seq mESC enhancer starr_05767 Neighboring gene predicted gene, 54132 Neighboring gene STARR-seq mESC enhancer starr_05768 Neighboring gene STARR-seq mESC enhancer starr_05769 Neighboring gene STARR-seq mESC enhancer starr_05770 Neighboring gene predicted gene, 52526 Neighboring gene STARR-positive B cell enhancer mm9_chr2:134469788-134470089 Neighboring gene thioredoxin-related transmembrane protein 4 Neighboring gene predicted gene 14037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HAO1 negatively regulates liver macrophage activation via the NF-κB pathway in alcohol-associated liver disease. Chen H, et al. Cell Signal, 2022 Nov. PMID 35953025
  2. Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling. Shi C, et al. Biochim Biophys Acta, 2013 Mar. PMID 23266618
  3. Identification and expression of a cDNA for human glycolate oxidase. Williams E, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978532
  4. Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. Kohler SA, et al. J Biol Chem, 1999 Jan 22. PMID 9891009
  5. The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Holmes RS. Genetics, 1977 Dec. PMID 604164, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HAO1 negatively regulates liver macrophage activation via the NF-kappaB pathway in alcohol-associated liver disease.
    Title: HAO1 negatively regulates liver macrophage activation via the NF-κB pathway in alcohol-associated liver disease.
  2. Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion.
    Title: Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141211

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (S)-2-hydroxy-acid oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (S)-2-hydroxy-acid oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables glyoxylate oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid alpha-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid alpha-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolate catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2-Hydroxyacid oxidase 1
Names
HAOX1
glycolate oxidase 1
glyoxylate oxidase
NP_034533.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010403.2 → NP_034533.1  2-Hydroxyacid oxidase 1

    See identical proteins and their annotated locations for NP_034533.1

    Status: PROVISIONAL

    Source sequence(s)
    AL845309
    Consensus CDS
    CCDS16783.1
    UniProtKB/Swiss-Prot
    Q9WU19
    UniProtKB/TrEMBL
    Q3UEE8
    Related
    ENSMUSP00000028704.3, ENSMUST00000028704.3
    Conserved Domains (2) summary
    cd02809
    Location:9 → 357
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:16 → 362
    FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    134339281..134396272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU19.1 GenPept UniProtKB/Swiss-Prot:Q9WU19

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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