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GAREM2 GRB2 associated regulator of MAPK1 subtype 2 [ Homo sapiens (human) ]

Gene ID: 150946, updated on 5-Mar-2024

Summary

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Official Symbol
GAREM2provided by HGNC
Official Full Name
GRB2 associated regulator of MAPK1 subtype 2provided by HGNC
Primary source
HGNC:HGNC:27172
See related
Ensembl:ENSG00000157833 MIM:617999; AllianceGenome:HGNC:27172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM59B; GAREML
Expression
Broad expression in brain (RPKM 5.7), testis (RPKM 1.0) and 17 other tissues See more
Orthologs
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Genomic context

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Location:
2p23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26173088..26204304)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26208391..26239634)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26395957..26412532)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387200-26387378 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387836-26388007 Neighboring gene peptidylprolyl isomerase like 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26398419-26398957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26401279-26402194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26402195-26403110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11270 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26465316-26465856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26467342-26468022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26468835-26469562 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene adhesion G protein-coupled receptor F3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. Taniguchi T, et al. J Biol Chem, 2013 Oct 11. PMID 24003223, Free PMC Article
  2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al. J Biol Chem, 2010 Oct 8. PMID 20682791, Free PMC Article
  3. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Bisson N, et al. Nat Biotechnol, 2011 Jun 26. PMID 21706016
  4. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Wong KA, et al. PLoS One, 2012. PMID 22558309, Free PMC Article
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Emdal KB, et al. Sci Signal, 2015 Apr 28. PMID 25921289

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00375, KIAA2038

General protein information

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Preferred Names
GRB2-associated and regulator of MAPK protein 2
Names
GRB2 associated regulator of MAPK1 2
GRB2 associated, regulator of MAPK1-like
GRB2-associated and regulator of MAPK protein-like
GRB2-associated and regulator of MAPK1-like
family with sequence similarity 59, member B
protein FAM59B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168241.2 → NP_001161713.1  GRB2-associated and regulator of MAPK protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001161713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AA736392, AB124552, AC011742, CX759737
    Consensus CDS
    CCDS54336.1
    UniProtKB/Swiss-Prot
    B5MC97, B7WNK9, Q75VX8, Q8NF27, Q9UIK8
    Related
    ENSP00000384593.1, ENST00000401533.7
    Conserved Domains (2) summary
    cd09525
    Location:806 → 872
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:29 → 341
    CABIT; Cell-cycle sustaining, positive selection,

  2. NM_001191033.2 → NP_001177962.1  GRB2-associated and regulator of MAPK protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA736392, AB015349, AC011742, AK090454
    Consensus CDS
    CCDS54337.1
    UniProtKB/Swiss-Prot
    Q75VX8
    Related
    ENSP00000384581.1, ENST00000407684.1
    Conserved Domains (2) summary
    cd09525
    Location:596 → 662
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:7 → 264
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    26173088..26204304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532567.4 → XP_011530869.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

    Conserved Domains (1) summary
    pfam12736
    Location:29 → 341
    CABIT; Cell-cycle sustaining, positive selection,

  2. XM_006711951.5 → XP_006712014.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q75VX8
    Conserved Domains (2) summary
    cd09525
    Location:673 → 739
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:29 → 341
    CABIT; Cell-cycle sustaining, positive selection,

  3. XM_011532565.4 → XP_011530867.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530867.1

    Conserved Domains (2) summary
    cd09525
    Location:804 → 870
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:36 → 339
    CABIT; Cell-cycle sustaining, positive selection,

  4. XM_011532564.3 → XP_011530866.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530866.1

    Conserved Domains (2) summary
    cd09525
    Location:804 → 870
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:36 → 339
    CABIT; Cell-cycle sustaining, positive selection,

  5. XM_011532566.3 → XP_011530868.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

    Conserved Domains (2) summary
    cd09525
    Location:687 → 753
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:1 → 222
    CABIT; Cell-cycle sustaining, positive selection,

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    26208391..26239634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340696.1 → XP_054196671.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

  2. XM_054340695.1 → XP_054196670.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

  3. XM_054340693.1 → XP_054196668.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

  4. XM_054340692.1 → XP_054196667.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

  5. XM_054340694.1 → XP_054196669.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75VX8.3 GenPept UniProtKB/Swiss-Prot:Q75VX8

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