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OR6B3 olfactory receptor family 6 subfamily B member 3 [ Homo sapiens (human) ]

Gene ID: 150681, updated on 5-Mar-2024

Summary

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Official Symbol
OR6B3provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily B member 3provided by HGNC
Primary source
HGNC:HGNC:15042
See related
Ensembl:ENSG00000178586 AllianceGenome:HGNC:15042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR6B3P; OR6B3Q
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See OR6B3 in Genome Data Viewer
Location:
2q37.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240044571..240053521, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (240537284..240546234, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240983988..240992938, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240884202-240885138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240885139-240886074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240890573-240891072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240894992-240895912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240895913-240896833 Neighboring gene microRNA 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17393 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:240964754-240965583 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:240985203-240986402 Neighboring gene olfactory receptor family 6 subfamily B member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240994250-240994892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240994893-240995533 Neighboring gene olfactory receptor family 9 subfamily S member 24 pseudogene Neighboring gene olfactory receptor family 5 subfamily S member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. Fung E, et al. EMBO Rep, 2018 Mar. PMID 29348145, Free PMC Article
  2. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. The protein interaction landscape of the human CMGC kinase group. Varjosalo M, et al. Cell Rep, 2013 Apr 25. PMID 23602568
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
olfactory receptor 6B3
Names
olfactory receptor OR2-2
olfactory receptor, family 6, subfamily B, member 3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173351.2 → NP_775486.1  olfactory receptor 6B3

    See identical proteins and their annotated locations for NP_775486.1

    Status: VALIDATED

    Source sequence(s)
    AC013469
    Consensus CDS
    CCDS42837.1
    UniProtKB/Swiss-Prot
    Q6IFH3, Q8NGW1
    UniProtKB/TrEMBL
    A0A126GW38
    Related
    ENSP00000493035.1, ENST00000641019.2
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42 → 305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240044571..240053521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    240537284..240546234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGW1.1 GenPept UniProtKB/Swiss-Prot:Q8NGW1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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