H2-T23 histocompatibility 2, T region locus 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-T23provided by MGI
Official Full Name: histocompatibility 2, T region locus 23provided by MGI
Primary source: MGI:MGI:95957
See related: Ensembl:ENSMUSG00000067212 AllianceGenome:MGI:95957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 37b; 37c; Qa1; Qa-1; T18c; T23b; T23d; H2-K1; Qed-1; H-2T23; H2-Qa1; Qa-1(b); T18c(37)
Summary: Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in small intestine adult (RPKM 290.8), large intestine adult (RPKM 270.0) and 18 other tissues See more
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Genomic context

Location:: 17 B1; 17 18.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36340869..36343593, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36029977..36032701, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The promiscuous development of an unconventional Qa1b-restricted T cell population.
Title: The promiscuous development of an unconventional Qa1b-restricted T cell population.
The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex.
Title: The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex.
Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine.
Title: Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine.
Qa-1(b) Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing.
Title: Qa-1(b) Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing.
Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.
Title: Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.
The murine CD94/NKG2 ligand, Qa-1(b), is a high-affinity, functional ligand for the CD8alphaalpha homodimer.
Title: The murine CD94/NKG2 ligand, Qa-1(b), is a high-affinity, functional ligand for the CD8αα homodimer.
Study using mouse model that harbors a point mutation in the class Ib MHC molecule Qa-1, which disrupts Qa-1 binding to the T cell receptor-CD8 complex and impairs the CD8 Treg response, revealed that Qa-1 mutant mice developed robust donor-specific antibody responses and accelerated heart graft rejection. Findings underscore the critical contribution of Qa-1-dependent regulatory pathway to graft survival.
Title: Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Authors demonstrate that the MHC class Ib molecule Qa-1 (encoded by H2-T23) restricts a large, and critical, portion of this population. These findings reveal a potential adaptation of the host immune response to compensate for viral evasion of classical T cell immunity.
Title: Qa-1-Restricted CD8(+) T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Reduced expression of Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer.
Title: Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells.
In this study of C57BL mice, both H2-T23b and H2-T11b histocompatibility antigens are functional genes.
Title: Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

33.MMHAP25FLC6.seq (e-PCR)
- UniSTS:124030

BE199223 (e-PCR)
- UniSTS:209307

H2-T23 (e-PCR), detects polymorphism
- UniSTS:525242

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-2-microglobulin binding	ISO Inferred from Sequence Orthology more info
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class I protein complex	ISO Inferred from Sequence Orthology more info
part_of MHC class Ib protein complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H-2 class I histocompatibility antigen, D-37 alpha chain

Names: MHC class I antigen Qa1; MHC class II antigen K; MHC classIb Qa1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010398.3 → NP_034528.1 H-2 class I histocompatibility antigen, D-37 alpha chain precursor

See identical proteins and their annotated locations for NP_034528.1

Status: PROVISIONAL

Source sequence(s)

AC112970

Consensus CDS

CCDS28715.1

UniProtKB/Swiss-Prot

P06339

UniProtKB/TrEMBL

O98032, Q3V014

Related

ENSMUSP00000099739.5, ENSMUST00000102678.5

Conserved Domains (3) summary

cd07698
Location:203 → 295

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cd12087
Location:296 → 333

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam00129
Location:22 → 199

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2