U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2-Q7 histocompatibility 2, Q region locus 7 [ Mus musculus (house mouse) ]

Gene ID: 15018, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
H2-Q7provided by MGI
Official Full Name
histocompatibility 2, Q region locus 7provided by MGI
Primary source
MGI:MGI:95936
See related
Ensembl:ENSMUSG00000060550 AllianceGenome:MGI:95936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Q9; Ped; Qa7; Qa-2; Qa-7; H-2Q7
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within cellular response to interferon-gamma and embryo implantation. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 272.5), mammary gland adult (RPKM 188.5) and 14 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 B1; 17 18.67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35658131..35662749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35439140..35443773)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5605 Neighboring gene STARR-positive B cell enhancer ABC_E8673 Neighboring gene STARR-positive B cell enhancer ABC_E118 Neighboring gene predicted gene, 32252 Neighboring gene histocompatibility 2, Q region locus 6 Neighboring gene STARR-positive B cell enhancer ABC_E315 Neighboring gene archain 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:35597630-35597931 Neighboring gene predicted gene, 54000

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice. Waneck GL, et al. J Exp Med, 1987 May 1. PMID 3502706, Free PMC Article
  2. Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen. Ulker N, et al. EMBO J, 1990 Dec. PMID 2249652, Free PMC Article
  3. Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth. Chiang EY, et al. J Immunol, 2003 May 1. PMID 12707328
  4. Two "Qa" specificities: Qa-m7 and Qa-m8 defined by monoclonal antibodies. Sandrin MS, et al. J Immunol, 1983 Aug. PMID 6190932
  5. Removal of Qa-2 antigen alters the Ped gene phenotype of preimplantation mouse embryos. Tian Z, et al. Biol Reprod, 1992 Aug. PMID 1327207

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP complex binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
H-2 class I histocompatibility antigen, Q7 alpha chain
Names
QA-2 antigen
class Ib MHC antigen Qa-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198560.1 → NP_001185489.1  H-2 class I histocompatibility antigen, Q7 alpha chain isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS57075.1
    UniProtKB/TrEMBL
    E9PWT4, E9QJR9
    Related
    ENSMUSP00000077335.8, ENSMUST00000078205.14
    Conserved Domains (2) summary
    cd07698
    Location:204 → 293
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:22 → 200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_001198561.1 → NP_001185490.1  H-2 class I histocompatibility antigen, Q7 alpha chain isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS57076.1
    UniProtKB/Swiss-Prot
    P14431
    UniProtKB/TrEMBL
    L7N260
    Related
    ENSMUSP00000112297.4, ENSMUST00000116598.10
    Conserved Domains (1) summary
    pfam00129
    Location:22 → 200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  3. NM_010394.4 → NP_034524.3  H-2 class I histocompatibility antigen, Q7 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_034524.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS28697.1
    UniProtKB/Swiss-Prot
    P14429
    UniProtKB/TrEMBL
    E9QJR9
    Related
    ENSMUSP00000071843.7, ENSMUST00000071951.14
    Conserved Domains (2) summary
    cd07698
    Location:204 → 295
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:22 → 200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35658131..35662749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14429.1 GenPept UniProtKB/Swiss-Prot:P14429

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous