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SIK1 salt inducible kinase 1 [ Homo sapiens (human) ]

Gene ID: 150094, updated on 5-Mar-2024

Summary

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Official Symbol
SIK1provided by HGNC
Official Full Name
salt inducible kinase 1provided by HGNC
Primary source
HGNC:HGNC:11142
See related
Ensembl:ENSG00000142178 MIM:605705; AllianceGenome:HGNC:11142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK; SIK; DEE30; SIK-1; SIK1B; SNF1LK
Summary
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in adrenal (RPKM 28.1), liver (RPKM 25.6) and 25 other tissues See more
Orthologs
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Genomic context

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See SIK1 in Genome Data Viewer
Location:
21q22.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43414483..43427131, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41769738..41782385, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44834363..44847011, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak4419 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44817000-44817548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44817549-44818097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44818515-44819191 Neighboring gene long intergenic non-protein coding RNA 3039 Neighboring gene uncharacterized LOC124905028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44828891-44829414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44829939-44830462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44830463-44830986 Neighboring gene Sharpr-MPRA regulatory region 3188 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:44833640-44834222 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44834223-44834804 Neighboring gene uncharacterized LOC124905029 Neighboring gene Sharpr-MPRA regulatory region 10850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44853691-44854192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44854193-44854692 Neighboring gene SIK1-LINC00319 intergenic CAGE-defined high expression enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44865413-44866032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44866033-44866652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:44867273-44867892 Neighboring gene uncharacterized LOC124900467 Neighboring gene long intergenic non-protein coding RNA 319 Neighboring gene heat shock transcription factor 2 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention. Zhang Y, et al. Life Sci, 2017 Mar 15. PMID 28174122
  2. Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology. Pröschel C, et al. Eur J Hum Genet, 2017 Feb. PMID 27966542, Free PMC Article
  3. De novo mutations in SIK1 cause a spectrum of developmental epilepsies. Hansen J, et al. Am J Hum Genet, 2015 Apr 2. PMID 25839329, Free PMC Article
  4. TGFbeta induces SIK to negatively regulate type I receptor kinase signaling. Kowanetz M, et al. J Cell Biol, 2008 Aug 25. PMID 18725536, Free PMC Article
  5. Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients. Anvarnia A, et al. Asian Pac J Cancer Prev, 2023 Apr 1. PMID 37116165, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health.
    Title: Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health.
  2. Down-Regulation and Clinic-Pathological Correlation of SIK-1 and SIL-1-LNC in Non-Small Cell Lung Cancer Patients.
    Title: Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients.
  3. Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis.
    Title: Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis.
  4. Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
    Title: Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
  5. Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
    Title: Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
  6. SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
    Title: SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
  7. Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.
    Title: Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.
  8. Sodium Channel Nav1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1.
    Title: Sodium Channel Na(v)1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1.
  9. An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
    Title: An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
  10. Data suggest that cAMP/protein kinase A-dependent phosphorylation of SIK1, SIK2, and SIK3 inhibits their catalytic activity by inducing 14-3-3 protein binding.
    Title: 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 30
MedGen: C4225360 OMIM: 616341 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of salt-inducible kinase 1 (SIK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cAMP response element binding protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anoikis IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase SIK1
Names
Probable serine/threonine-protein kinase SIK1B
SNF1-like kinase
Salt-inducible kinase 1B
myocardial SNF1-like kinase
salt-inducible protein kinase 1
serine/threonine-protein kinase SNF1-like kinase 1
serine/threonine-protein kinase SNF1LK
NP_775490.2
XP_011527776.1
XP_054180338.1
XP_054180339.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052009.1 RefSeqGene

    Range
    5002..17650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173354.5 → NP_775490.2  serine/threonine-protein kinase SIK1

    See identical proteins and their annotated locations for NP_775490.2

    Status: REVIEWED

    Source sequence(s)
    AB047786, AP001046, HY008464
    Consensus CDS
    CCDS33575.1
    UniProtKB/Swiss-Prot
    A6NC84, P57059, Q5R2V5, Q6ZNL8, Q86YJ2
    Related
    ENSP00000270162.6, ENST00000270162.8
    Conserved Domains (3) summary
    smart00220
    Location:27 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14408
    Location:300 → 349
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cd14071
    Location:26 → 278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    43414483..43427131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529474.3 → XP_011527776.1  serine/threonine-protein kinase SIK1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:27 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14071
    Location:26 → 278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    41769738..41782385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324363.1 → XP_054180338.1  serine/threonine-protein kinase SIK1 isoform X1

  2. XM_054324364.1 → XP_054180339.1  serine/threonine-protein kinase SIK1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57059.2 GenPept UniProtKB/Swiss-Prot:P57059

Gene LinkOut

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