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H2-Ob histocompatibility 2, O region beta locus [ Mus musculus (house mouse) ]

Gene ID: 15002, updated on 21-Apr-2024

Summary

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Official Symbol
H2-Obprovided by MGI
Official Full Name
histocompatibility 2, O region beta locusprovided by MGI
Primary source
MGI:MGI:95925
See related
Ensembl:ENSMUSG00000041538 AllianceGenome:MGI:95925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ob; H-2I; vic1; H-2Ab; H-2Ob; H2-Ab; H2-Ab2; A-beta2; H2-IAb2; A-beta-2
Summary
Predicted to enable MHC class II protein complex binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; and peptide antigen assembly with MHC class II protein complex. Predicted to be located in lysosome. Predicted to be part of MHC class II protein complex. Is expressed in hemolymphoid system and metanephros. Orthologous to human HLA-DOB (major histocompatibility complex, class II, DO beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 49.9), mammary gland adult (RPKM 16.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34457879..34464882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34238905..34245908)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34347631-34347818 Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene STARR-positive B cell enhancer ABC_E4208 Neighboring gene STARR-positive B cell enhancer ABC_E4209 Neighboring gene STARR-positive B cell enhancer ABC_E4210 Neighboring gene STARR-positive B cell enhancer ABC_E7524 Neighboring gene predicted gene 20506 Neighboring gene STARR-positive B cell enhancer ABC_E768 Neighboring gene STARR-positive B cell enhancer ABC_E1193 Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene histocompatibility 2, class II antigen A, beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel mechanism of resistance to mouse mammary tumor virus infection. Golovkina TV. J Virol, 2000 Mar. PMID 10684291, Free PMC Article
  2. The sheep orthologue of the HLA-DOB gene. Wright H, et al. Immunogenetics, 1996. PMID 8537127
  3. Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis. Brunsberg U, et al. Eur J Immunol, 1994 Jul. PMID 8026530
  4. MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4(+) T cells. Logunova NN, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32482872, Free PMC Article
  5. Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases. Welsh RA, et al. PLoS Biol, 2020 Feb. PMID 32069316, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proper development of long-lived memory CD4 T cells requires HLA-DO function.
    Title: Proper development of long-lived memory CD4 T cells requires HLA-DO function.
  2. Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development.
    Title: Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.
  3. these results report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain; it encodes the beta subunit of the non-classical major histocompatibility complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen presentation
    Title: Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.
  4. H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor.
    Title: Downmodulation of antigen presentation by H2-O in B cell lines and primary B lymphocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, O region beta locus
Names
H2-IA-beta-2 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010389.3 → NP_034519.2  histocompatibility 2, O region beta locus precursor

    See identical proteins and their annotated locations for NP_034519.2

    Status: VALIDATED

    Source sequence(s)
    AF027865, AK053233, AK155650, BY205160
    Consensus CDS
    CCDS37582.1
    UniProtKB/TrEMBL
    O35424, Q3U1X7
    Related
    ENSMUSP00000092985.4, ENSMUST00000095342.11
    Conserved Domains (2) summary
    pfam00969
    Location:39 → 113
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:123 → 214
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34457879..34464882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523686.3 → XP_006523749.1  histocompatibility 2, O region beta locus isoform X1

    See identical proteins and their annotated locations for XP_006523749.1

    Conserved Domains (2) summary
    cl03042
    Location:1 → 42
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:52 → 143
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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