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H2-DMb2 histocompatibility 2, class II, locus Mb2 [ Mus musculus (house mouse) ]

Gene ID: 15000, updated on 5-Mar-2024

Summary

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Official Symbol
H2-DMb2provided by MGI
Official Full Name
histocompatibility 2, class II, locus Mb2provided by MGI
Primary source
MGI:MGI:95923
See related
Ensembl:ENSMUSG00000037548 AllianceGenome:MGI:95923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Mb2; H2-Mb2
Summary
Predicted to enable MHC class II protein complex binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and chaperone cofactor-dependent protein refolding. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is integral component of membrane. Orthologous to human HLA-DMB (major histocompatibility complex, class II, DM beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 391.6), mammary gland adult (RPKM 128.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34362203..34370527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34143229..34151553)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene STARR-positive B cell enhancer ABC_E7523 Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene STARR-positive B cell enhancer ABC_E11638 Neighboring gene STARR-positive B cell enhancer ABC_E1939 Neighboring gene STARR-seq mESC enhancer starr_42425 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of mouse H2-M. Fremont DH, et al. Immunity, 1998 Sep. PMID 9768758
  2. Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development. Georgiades P, et al. Immunology, 1996 Jul. PMID 8774363, Free PMC Article
  3. H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove. Walter W, et al. Immunogenetics, 1996. PMID 8613139
  4. Characterization of polymorphism within the H2-M MHC class II loci. Hermel E, et al. Immunogenetics, 1995. PMID 7607704
  5. New class II-like genes in the murine MHC. Cho SG, et al. Nature, 1991 Oct 10. PMID 1922366

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MHC class II protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide antigen assembly with MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histocompatibility 2, class II, locus Mb2
Names
H2-M beta2
MHC class II antigen Mb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010388.5 → NP_034518.1  histocompatibility 2, class II, locus Mb2 precursor

    See identical proteins and their annotated locations for NP_034518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    CR974422
    Consensus CDS
    CCDS37580.1
    UniProtKB/TrEMBL
    Q31099, Q31609, Q60975, Q95552
    Related
    ENSMUSP00000043526.8, ENSMUST00000041982.9
    Conserved Domains (3) summary
    smart00410
    Location:129 → 201
    IG_like; Immunoglobulin like
    pfam00969
    Location:27 → 106
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:115 → 209
    Ig; Immunoglobulin domain

RNA

  1. NR_160895.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974422
    Related
    ENSMUST00000171231.8

  2. NR_160896.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974422
    Related
    ENSMUST00000236519.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34362203..34370527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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