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H2-M10.1 histocompatibility 2, M region locus 10.1 [ Mus musculus (house mouse) ]

Gene ID: 14985, updated on 11-Apr-2024

Summary

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Official Symbol
H2-M10.1provided by MGI
Official Full Name
histocompatibility 2, M region locus 10.1provided by MGI
Primary source
MGI:MGI:1276522
See related
Ensembl:ENSMUSG00000024448 AllianceGenome:MGI:1276522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9.5H
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
17 B1; 17 19.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36633752..36637042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36322860..36326150, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42489 Neighboring gene histocompatibility 2, M region locus 10.2 Neighboring gene predicted gene, 33257 Neighboring gene histocompatibility 2, M region locus 10.3 Neighboring gene histocompatibility 2, M region locus 10.5, pseudogene 1 Neighboring gene serine/threonine kinase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Loconto J, et al. Cell, 2003 Mar 7. PMID 12628182
  2. Combinatorial coexpression of neural and immune multigene families in mouse vomeronasal sensory neurons. Ishii T, et al. Curr Biol, 2003 Mar 4. PMID 12620187
  3. Characterization of two class I genes from the H2-M region: evidence for a new subfamily. Arepalli SR, et al. Immunogenetics, 1998. PMID 9435345
  4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, M region locus 10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360498.1 → NP_001347427.1  histocompatibility 2, M region locus 10.1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter, compared to isoform 1.
    Source sequence(s)
    AC129554
    UniProtKB/TrEMBL
    G3UWS8
    Related
    ENSMUSP00000133408.2, ENSMUST00000172576.2
    Conserved Domains (2) summary
    cd07698
    Location:164 → 256
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:26 → 160
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_013544.3 → NP_038572.3  histocompatibility 2, M region locus 10.1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_038572.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF539597, AY211079
    Consensus CDS
    CCDS28721.1
    UniProtKB/TrEMBL
    O19443, Q860W7
    Related
    ENSMUSP00000025322.8, ENSMUST00000025322.14
    Conserved Domains (2) summary
    cd07698
    Location:207 → 299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:25 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36633752..36637042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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