H2-Bl histocompatibility 2, blastocyst [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Blprovided by MGI
Official Full Name: histocompatibility 2, blastocystprovided by MGI
Primary source: MGI:MGI:892004
See related: Ensembl:ENSMUSG00000073406 AllianceGenome:MGI:892004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H2-B1; H2-D1; H2-K1; H-2T13; H2-T13; H2-Bl-like
Summary: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including gut; liver lobe; orbito-sphenoid; placenta; and yolk sac. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Biased expression in small intestine adult (RPKM 169.8), duodenum adult (RPKM 41.1) and 2 other tissues See more
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Genomic context

Location:: 17 B1; 17 18.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36391002..36395141, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36080110..36084249, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative splicing of H2-Bl mRNA in gut tissues leads to strain-dependent expression of diverse repertoires of canonical and noncanonical transcripts that may give rise to distinct ligands for gut-restricted lymphocyte receptors
Title: The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC".
The aberrant expression of blastocyst MHC in transporter associated with antigen processing (TAP)-deficient trophoblasts and tumor cells confers protection from natural killer cell attack in vivo.
Title: Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo.

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General gene information

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Markers

H2-K1 (e-PCR), detects polymorphism
- UniSTS:463411

H2-T13 (e-PCR), detects polymorphism
- UniSTS:525239

H2-Bl (e-PCR), detects polymorphism
- UniSTS:256470

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histocompatibility 2, blastocyst

Names: H2 blastocyst; MHC class II antigen D; MHC class II antigen K; blastocyst MHC; histocompatibility 2, T region locus 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008199.3 → NP_032225.3 histocompatibility 2, blastocyst precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some mouse strains, including the C57BL/6 strain of the reference genome.

Source sequence(s)

AY989821, AY989839, BY093962, CT030728

UniProtKB/TrEMBL

O19440

RNA

NR_160676.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) contains a premature stop codon, and represents the non-functional allele present in some mouse strains, including the C57BL/6 strain of the reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY989821, BY093962, CT030728

Related

ENSMUST00000173080.10