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LRRC71 leucine rich repeat containing 71 [ Homo sapiens (human) ]

Gene ID: 149499, updated on 3-Apr-2024

Summary

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Official Symbol
LRRC71provided by HGNC
Official Full Name
leucine rich repeat containing 71provided by HGNC
Primary source
HGNC:HGNC:26556
See related
Ensembl:ENSG00000160838 AllianceGenome:HGNC:26556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf92
Expression
Restricted expression toward testis (RPKM 8.7) See more
Orthologs
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Genomic context

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Location:
1q23.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156920632..156941073)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156057478..156077914)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156890424..156902886)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811133-156811814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811815-156812494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156814249-156814884 Neighboring gene Sharpr-MPRA regulatory region 5756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156830955-156831498 Neighboring gene insulin receptor related receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156836581-156837238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156844837-156845734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156862813-156863317 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:156865761-156866960 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1441 Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene microRNA 765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156951350-156951542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156961673-156962173 Neighboring gene RNA, 7SL, cytoplasmic 612, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1443 Neighboring gene uncharacterized LOC102724222

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Maio N, et al. Cell Metab, 2017 Apr 4. PMID 28380382
  2. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside. Sun X, et al. J Ginseng Res, 2022 Mar. PMID 35509820, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32884, FLJ77598, MGC45468

General protein information

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Preferred Names
leucine-rich repeat-containing protein 71
Names
leucine-rich repeat-containing protein C10orf92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144702.3 → NP_653303.2  leucine-rich repeat-containing protein 71

    See identical proteins and their annotated locations for NP_653303.2

    Status: VALIDATED

    Source sequence(s)
    AK292342, AL356104, BC033790, BU689904
    Consensus CDS
    CCDS44249.1
    UniProtKB/Swiss-Prot
    Q8N4P6, Q96M24
    UniProtKB/TrEMBL
    A8K8H7
    Related
    ENSP00000336661.7, ENST00000337428.8
    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156920632..156941073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000459.3 → XP_016855948.1  leucine-rich repeat-containing protein 71 isoform X7

  2. XM_047447397.1 → XP_047303353.1  leucine-rich repeat-containing protein 71 isoform X2

  3. XM_006711185.4 → XP_006711248.1  leucine-rich repeat-containing protein 71 isoform X2

    See identical proteins and their annotated locations for XP_006711248.1

    UniProtKB/TrEMBL
    A8K8H7
    Related
    ENST00000490146.5
    Conserved Domains (2) summary
    cd00116
    Location:134 → 281
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:141 → 169
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_005244926.4 → XP_005244983.1  leucine-rich repeat-containing protein 71 isoform X1

    UniProtKB/TrEMBL
    A8K8H7
    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_006711186.4 → XP_006711249.1  leucine-rich repeat-containing protein 71 isoform X3

    UniProtKB/TrEMBL
    A8K8H7
    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_006711187.4 → XP_006711250.1  leucine-rich repeat-containing protein 71 isoform X4

    UniProtKB/TrEMBL
    A8K8H7
    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  7. XM_005244927.4 → XP_005244984.1  leucine-rich repeat-containing protein 71 isoform X5

    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  8. XM_005244928.3 → XP_005244985.1  leucine-rich repeat-containing protein 71 isoform X6

    UniProtKB/TrEMBL
    A8K8H7
    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  9. XM_047447415.1 → XP_047303371.1  leucine-rich repeat-containing protein 71 isoform X9

  10. XM_011509241.3 → XP_011507543.1  leucine-rich repeat-containing protein 71 isoform X11

    Conserved Domains (2) summary
    cd00116
    Location:161 → 308
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:168 → 196
    LRR_RI; leucine-rich repeat [structural motif]

  11. XM_017000462.3 → XP_016855951.1  leucine-rich repeat-containing protein 71 isoform X10

    Conserved Domains (2) summary
    cd00116
    Location:9 → 93
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:9 → 34
    LRR_1; leucine-rich repeat [structural motif]

  12. XM_011509239.3 → XP_011507541.1  leucine-rich repeat-containing protein 71 isoform X8

    Conserved Domains (2) summary
    cd00116
    Location:9 → 122
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:11 → 31
    LRR_RI; leucine-rich repeat [structural motif]

  13. XM_047447420.1 → XP_047303376.1  leucine-rich repeat-containing protein 71 isoform X12

  14. XM_047447421.1 → XP_047303377.1  leucine-rich repeat-containing protein 71 isoform X13

  15. XM_011509240.4 → XP_011507542.1  leucine-rich repeat-containing protein 71 isoform X10

    See identical proteins and their annotated locations for XP_011507542.1

    Conserved Domains (2) summary
    cd00116
    Location:9 → 93
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:9 → 34
    LRR_1; leucine-rich repeat [structural motif]

RNA

  1. XR_241072.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156057478..156077914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334682.1 → XP_054190657.1  leucine-rich repeat-containing protein 71 isoform X7

  2. XM_054334677.1 → XP_054190652.1  leucine-rich repeat-containing protein 71 isoform X2

  3. XM_054334676.1 → XP_054190651.1  leucine-rich repeat-containing protein 71 isoform X2

  4. XM_054334675.1 → XP_054190650.1  leucine-rich repeat-containing protein 71 isoform X1

  5. XM_054334678.1 → XP_054190653.1  leucine-rich repeat-containing protein 71 isoform X3

  6. XM_054334679.1 → XP_054190654.1  leucine-rich repeat-containing protein 71 isoform X4

  7. XM_054334680.1 → XP_054190655.1  leucine-rich repeat-containing protein 71 isoform X5

  8. XM_054334681.1 → XP_054190656.1  leucine-rich repeat-containing protein 71 isoform X6

  9. XM_054334684.1 → XP_054190659.1  leucine-rich repeat-containing protein 71 isoform X9

  10. XM_054334688.1 → XP_054190663.1  leucine-rich repeat-containing protein 71 isoform X11

  11. XM_054334685.1 → XP_054190660.1  leucine-rich repeat-containing protein 71 isoform X10

  12. XM_054334686.1 → XP_054190661.1  leucine-rich repeat-containing protein 71 isoform X10

  13. XM_054334683.1 → XP_054190658.1  leucine-rich repeat-containing protein 71 isoform X8

  14. XM_054334689.1 → XP_054190664.1  leucine-rich repeat-containing protein 71 isoform X12

  15. XM_054334690.1 → XP_054190665.1  leucine-rich repeat-containing protein 71 isoform X13

  16. XM_054334687.1 → XP_054190662.1  leucine-rich repeat-containing protein 71 isoform X10

RNA

  1. XR_008485936.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N4P6.1 GenPept UniProtKB/Swiss-Prot:Q8N4P6

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