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Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 14924, updated on 21-Apr-2024

Summary

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Official Symbol
Magi1provided by MGI
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 1provided by MGI
Primary source
MGI:MGI:1203522
See related
Ensembl:ENSMUSG00000045095 AllianceGenome:MGI:1203522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIP3; BAP1; WWP3; Baiap1; Gukmi1; MAGI1c; Magi-1; TNRC19; mKIAA4129
Summary
Predicted to enable alpha-actinin binding activity. Predicted to be involved in positive regulation of cell-cell adhesion and signal transduction. Located in several cellular components, including adherens junction; cytoplasm; and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and musculoskeletal system. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 9.8), whole brain E14.5 (RPKM 9.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 42.7 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (93652434..94260906, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (93675453..94283929, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22312 Neighboring gene STARR-seq mESC enhancer starr_16685 Neighboring gene STARR-seq mESC enhancer starr_16686 Neighboring gene STARR-seq mESC enhancer starr_16687 Neighboring gene STARR-seq mESC enhancer starr_16688 Neighboring gene ribosomal protein P0 pseudogene Neighboring gene predicted gene, 53322 Neighboring gene VISTA enhancer mm1316 Neighboring gene STARR-seq mESC enhancer starr_16692 Neighboring gene predicted gene, 23035 Neighboring gene predicted gene, 22840 Neighboring gene STARR-seq mESC enhancer starr_16697 Neighboring gene STARR-seq mESC enhancer starr_16699 Neighboring gene RIKEN cDNA 4930511A08 gene Neighboring gene STARR-seq mESC enhancer starr_16702 Neighboring gene STARR-seq mESC enhancer starr_16704 Neighboring gene predicted gene, 31661 Neighboring gene predicted gene, 19908

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MAGI1 inhibits interferon signaling to promote influenza A infection. Wang Y, et al. Front Cardiovasc Med, 2022. PMID 36082118, Free PMC Article
  2. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Glaunsinger BA, et al. Oncogene, 2000 Nov 2. PMID 11077444, Free PMC Article
  3. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Matsuzawa K, et al. Commun Biol, 2021 Mar 12. PMID 33712709, Free PMC Article
  4. Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells. Qi Y, et al. Neurosci Lett, 2013 May 10. PMID 23523645
  5. Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Gregorc U, et al. Apoptosis, 2007 Feb. PMID 17191119, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
    Title: MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
  2. Study in mouse model of atherosclerosis suggests that MAGI1 simultaneously regulates endothelial cells activation and endoplasmic reticulum stress-induced apoptosis, which are critical molecular events for atherogenesis, via MAGI1-S741 phosphorylation by p90RSK and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation.
    Title: MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.
  3. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
    Title: MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.
  4. Cx32 expression is in part related to induction of tight junctions through modulation of Magi1 expression in an immortalized hepatic cell line.
    Title: Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.
  5. ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct.
    Title: Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells.
  6. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function.
    Title: Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis.
  7. Depletion of MAGI-1 from photorecptors by RNA interference blocks synaptic localization of Sidekick-2 in photoreceptors without affecting localization of postsynaptic density (PSD)-95.
    Title: Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins.
  8. MAGI-1 together with JAM4 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells
    Title: JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.
  9. We found MAGI-1 to be associated with cell-cell contacts in human umbilical vein endothelial cells (HUVECs) and in mouse endothelium, where it colocalizes with ESAM.
    Title: Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts.
  10. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system
    Title: MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4129

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Names
BAI1-associated protein 1
membrane-associated guanylate kinase inverted 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029850.5 → NP_001025021.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c

    See identical proteins and their annotated locations for NP_001025021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC138381, AC153601, AC162382
    Consensus CDS
    CCDS20377.1
    UniProtKB/Swiss-Prot
    O54893, O54894, O54895, Q6RHR9
    UniProtKB/TrEMBL
    B9EKC0
    Related
    ENSMUSP00000086730.6, ENSMUST00000089317.12
    Conserved Domains (6) summary
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1132 → 1214
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:988 → 1071
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:361 → 390
    WW; WW domain
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  2. NM_001083320.3 → NP_001076789.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and has multiple differences in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
    Source sequence(s)
    AC138381, AC153601
    Consensus CDS
    CCDS39573.1
    UniProtKB/TrEMBL
    E9PZ12, Q5DTM1
    Related
    ENSMUSP00000091283.6, ENSMUST00000093769.8
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:916 → 998
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:974 → 1223
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:760 → 855
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:489 → 570
    MAGI_u5; Unstructured region on MAGI

  3. NM_001083321.3 → NP_001076790.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c. Variants 1, 27, and 29 all encode the same isoform (d).
    Source sequence(s)
    AC138381, AC153601
    Consensus CDS
    CCDS85098.1
    UniProtKB/TrEMBL
    A0A0N4SWH0, Q5DTM1
    Related
    ENSMUSP00000145515.2, ENSMUST00000203688.3
    Conserved Domains (6) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:916 → 998
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:76 → 105
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:761 → 855
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  4. NM_001286784.2 → NP_001273713.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e

    See identical proteins and their annotated locations for NP_001273713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes isoform e, which is shorter than isoform c.
    Source sequence(s)
    AC138381, AC153601, AC162382
    UniProtKB/TrEMBL
    B9EKC0, Q4H4B4
    Conserved Domains (6) summary
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1131 → 1213
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:976 → 1070
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:349 → 378
    WW; WW domain
    pfam16666
    Location:702 → 785
    MAGI_u5; Unstructured region on MAGI

  5. NM_001286785.2 → NP_001273714.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC138381, AC153601, AC162382
    Consensus CDS
    CCDS85099.1
    UniProtKB/TrEMBL
    A0A0N4SUZ0, B9EKC0
    Related
    ENSMUSP00000144881.2, ENSMUST00000204347.3
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1144 → 1226
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:988 → 1083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  6. NM_001286786.2 → NP_001273715.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform g

    See identical proteins and their annotated locations for NP_001273715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains multiple coding region differences compared to variant 3, and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform g, which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC138381, AC153601, AC162382
    UniProtKB/TrEMBL
    B9EKC0, Q4H4B5
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1131 → 1213
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:976 → 1070
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:702 → 785
    MAGI_u5; Unstructured region on MAGI

  7. NM_001286788.2 → NP_001273717.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC138381, AC153601
    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (6) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:914 → 996
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:76 → 105
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:759 → 853
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  8. NM_001409967.1 → NP_001396896.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601, AC162382

  9. NM_001409968.1 → NP_001396897.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601, AC162382

  10. NM_001409969.1 → NP_001396898.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  11. NM_001409970.1 → NP_001396899.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  12. NM_001409971.1 → NP_001396900.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  13. NM_001409972.1 → NP_001396901.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  14. NM_001409973.1 → NP_001396902.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601, AC162382
    Related
    ENSMUSP00000145244.2, ENSMUST00000203519.3

  15. NM_001409974.1 → NP_001396903.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  16. NM_001409975.1 → NP_001396904.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  17. NM_001409976.1 → NP_001396905.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  18. NM_001409978.1 → NP_001396907.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  19. NM_001409979.1 → NP_001396908.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform t

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  20. NM_001409980.1 → NP_001396909.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform u

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  21. NM_001409982.1 → NP_001396911.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  22. NM_001409983.1 → NP_001396912.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  23. NM_001409984.1 → NP_001396913.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  24. NM_001409985.1 → NP_001396914.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  25. NM_001409986.1 → NP_001396915.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601
    UniProtKB/TrEMBL
    A0A0N4SWH0

  26. NM_001409987.1 → NP_001396916.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  27. NM_001409988.1 → NP_001396917.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601
    UniProtKB/TrEMBL
    A0A0N4SWH0

  28. NM_001409989.1 → NP_001396918.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  29. NM_001409990.1 → NP_001396919.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform y

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  30. NM_001409991.1 → NP_001396920.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform z

    Status: VALIDATED

    Source sequence(s)
    AC138381, AC153601

  31. NM_010367.4 → NP_034497.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_034497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC138381, AC153601, AC162382
    Consensus CDS
    CCDS20378.1
    UniProtKB/TrEMBL
    A0A0R4J0S6, Q4VBG2
    Related
    ENSMUSP00000062085.9, ENSMUST00000055224.15
    Conserved Domains (6) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1035 → 1117
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:798 → 873
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:702 → 784
    MAGI_u5; Unstructured region on MAGI

RNA

  1. NR_104594.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138381, AC153601
    Related
    ENSMUST00000204532.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    93652434..94260906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505586.3 → XP_006505649.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:349 → 380
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1132 → 1214
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1190 → 1439
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:976 → 1071
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:702 → 785
    MAGI_u5; Unstructured region on MAGI

  2. XM_036165869.1 → XP_036021762.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1075 → 1157
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1133 → 1382
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:838 → 913
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:716 → 797
    MAGI_u5; Unstructured region on MAGI

  3. XM_006505584.3 → XP_006505647.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1143 → 1225
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1201 → 1450
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:987 → 1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:714 → 796
    MAGI_u5; Unstructured region on MAGI

  4. XM_030255179.2 → XP_030111039.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    Q4VBG2
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1048 → 1130
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1106 → 1355
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:811 → 886
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  5. XM_006505600.3 → XP_006505663.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1115 → 1197
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1173 → 1422
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:960 → 1054
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  6. XM_036165867.1 → XP_036021760.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1116 → 1198
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1174 → 1423
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:960 → 1055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:716 → 804
    MAGI_u5; Unstructured region on MAGI

  7. XM_030255186.2 → XP_030111046.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

    UniProtKB/TrEMBL
    Q4VBG2
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1076 → 1158
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:839 → 914
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  8. XM_006505601.4 → XP_006505664.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1143 → 1225
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:988 → 1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  9. XM_006505581.3 → XP_006505644.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:361 → 392
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1144 → 1226
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1202 → 1451
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:988 → 1083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:714 → 797
    MAGI_u5; Unstructured region on MAGI

  10. XM_036165868.1 → XP_036021761.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1076 → 1158
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1134 → 1383
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:839 → 914
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:717 → 798
    MAGI_u5; Unstructured region on MAGI

  11. XM_030255184.2 → XP_030111044.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1143 → 1225
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:988 → 1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 797
    MAGI_u5; Unstructured region on MAGI

  12. XM_006505583.3 → XP_006505646.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1144 → 1226
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1202 → 1451
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:988 → 1083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 797
    MAGI_u5; Unstructured region on MAGI

  13. XM_036165876.1 → XP_036021769.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

    UniProtKB/TrEMBL
    Q4VBG2
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1105 → 1187
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:961 → 1044
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:717 → 805
    MAGI_u5; Unstructured region on MAGI

  14. XM_006505588.3 → XP_006505651.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1116 → 1198
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1174 → 1423
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:961 → 1055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  15. XM_006505587.3 → XP_006505650.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1117 → 1199
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1175 → 1424
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:961 → 1056
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  16. XM_036165872.1 → XP_036021765.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1117 → 1199
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:961 → 1056
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:717 → 805
    MAGI_u5; Unstructured region on MAGI

  17. XM_006505589.3 → XP_006505652.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1077 → 1159
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1135 → 1384
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:840 → 915
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  18. XM_017321400.3 → XP_017176889.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1077 → 1159
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:840 → 915
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  19. XM_036165873.1 → XP_036021766.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1077 → 1159
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:840 → 915
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:717 → 799
    MAGI_u5; Unstructured region on MAGI

  20. XM_006505585.3 → XP_006505648.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1133 → 1215
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1191 → 1440
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:989 → 1072
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  21. XM_017321399.3 → XP_017176888.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1133 → 1215
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:989 → 1072
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  22. XM_006505582.3 → XP_006505645.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1144 → 1226
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1202 → 1451
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:989 → 1083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  23. XM_006505593.4 → XP_006505656.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1144 → 1226
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:989 → 1083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  24. XM_006505580.3 → XP_006505643.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (7) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1145 → 1227
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:1203 → 1452
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:989 → 1084
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:302 → 331
    WW; WW domain
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  25. XM_006505592.3 → XP_006505655.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1145 → 1227
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:989 → 1084
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  26. XM_006505591.3 → XP_006505654.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

    UniProtKB/TrEMBL
    B9EKC0
    Conserved Domains (6) summary
    smart00456
    Location:362 → 393
    WW; Domain with 2 conserved Trp (W) residues
    smart00072
    Location:122 → 293
    GuKc; Guanylate kinase homologues
    smart00228
    Location:1145 → 1227
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:303 → 332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:989 → 1084
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16666
    Location:715 → 798
    MAGI_u5; Unstructured region on MAGI

  27. XM_036165874.1 → XP_036021767.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:122 → 153
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:905 → 987
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:963 → 1212
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:749 → 844
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:477 → 559
    MAGI_u5; Unstructured region on MAGI

  28. XM_006505599.5 → XP_006505662.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

    See identical proteins and their annotated locations for XP_006505662.1

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:917 → 999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:975 → 1224
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:761 → 856
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  29. XM_006505594.5 → XP_006505657.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

    See identical proteins and their annotated locations for XP_006505657.1

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:918 → 1000
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:976 → 1225
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:762 → 857
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:488 → 571
    MAGI_u5; Unstructured region on MAGI

  30. XM_030255181.2 → XP_030111041.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:917 → 999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:975 → 1224
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:761 → 856
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  31. XM_006505596.4 → XP_006505659.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

    See identical proteins and their annotated locations for XP_006505659.1

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:918 → 1000
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:976 → 1225
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:762 → 857
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:488 → 571
    MAGI_u5; Unstructured region on MAGI

  32. XM_006505597.5 → XP_006505660.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

    See identical proteins and their annotated locations for XP_006505660.1

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:135 → 166
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:918 → 1000
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:976 → 1225
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:762 → 857
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:488 → 571
    MAGI_u5; Unstructured region on MAGI

  33. XM_030255183.2 → XP_030111043.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:916 → 998
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:974 → 1223
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:761 → 855
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  34. XM_006505598.5 → XP_006505661.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

    See identical proteins and their annotated locations for XP_006505661.1

    UniProtKB/TrEMBL
    Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:917 → 999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:975 → 1224
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:761 → 856
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:487 → 570
    MAGI_u5; Unstructured region on MAGI

  35. XM_036165871.1 → XP_036021764.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

    UniProtKB/TrEMBL
    E9PZ12, Q5DTM1
    Conserved Domains (7) summary
    smart00456
    Location:134 → 165
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:916 → 998
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PRK12678
    Location:974 → 1223
    PRK12678; transcription termination factor Rho; Provisional
    cd00992
    Location:760 → 855
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:75 → 104
    WW; WW domain
    pfam16663
    Location:1 → 34
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:489 → 570
    MAGI_u5; Unstructured region on MAGI
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RHR9.1 GenPept UniProtKB/Swiss-Prot:Q6RHR9

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