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Gucy2c guanylate cyclase 2c [ Mus musculus (house mouse) ]

Gene ID: 14917, updated on 21-Apr-2024

Summary

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Official Symbol
Gucy2cprovided by MGI
Official Full Name
guanylate cyclase 2cprovided by MGI
Primary source
MGI:MGI:106903
See related
Ensembl:ENSMUSG00000042638 AllianceGenome:MGI:106903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcc; GC-C
Summary
Enables guanylate cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system and liver. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 40.4), colon adult (RPKM 29.3) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 66.67 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136674282..136758740, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136697284..136781742, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 1 Neighboring gene predicted gene, 40409 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene protein S100-A10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136692382-136692565 Neighboring gene predicted gene, 40411 Neighboring gene H4 histone 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C. Mishra V, et al. J Exp Med, 2021 Nov 1. PMID 34546338, Free PMC Article
  2. The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model. Lan D, et al. Acta Biochim Pol, 2020 Sep 7. PMID 32894825
  3. Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent. Habek N, et al. Pflugers Arch, 2020 Mar. PMID 31940065
  4. Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes. Mann EA, et al. Genes Brain Behav, 2019 Jun. PMID 30953414
  5. TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C. Abraham TS, et al. J Immunol, 2019 Feb 15. PMID 30642983, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal neuropod cell GUCY2C regulates visceral pain.
    Title: Intestinal neuropod cell GUCY2C regulates visceral pain.
  2. Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
    Title: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
  3. The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
    Title: The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
  4. Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
    Title: Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
  5. Study reveals two discrete neuronal circuits expressing GUCY2C originating in the ventral premammillary nucleus in the hypothalamus and in the ventral tegmental area and substantia nigra in midbrain, which separately project to other sites throughout the brain.
    Title: Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.
  6. Gucy2c knockout mice have a moderate cognitive and startle phenotype but have no ADHD-like phenotype.
    Title: Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes.
  7. This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity.
    Title: TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
  8. Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
    Title: Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
  9. Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival.
    Title: Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.
  10. Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome.
    Title: GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107510

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylyl cyclase C
Names
STA receptor
heat-stable enterotoxin receptor
intestinal guanylate cyclase
NP_001120790.1
NP_659504.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127318.1 → NP_001120790.1  guanylyl cyclase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1).
    Source sequence(s)
    AK136496, CF353627
    Consensus CDS
    CCDS51941.1
    UniProtKB/Swiss-Prot
    Q3UWA6, Q499D2, Q8JZQ6
    Related
    ENSMUSP00000032338.8, ENSMUST00000032338.10
    Conserved Domains (5) summary
    smart00044
    Location:787 → 978
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    smart00221
    Location:502 → 744
    STYKc; Protein kinase; unclassified specificity
    pfam00211
    Location:814 → 1001
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl10011
    Location:35 → 415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21453
    Location:480 → 749
    PKc_like; Protein Kinases, catalytic domain

  2. NM_145067.3 → NP_659504.2  guanylyl cyclase C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK136496, CF353627
    Consensus CDS
    CCDS20653.1
    UniProtKB/Swiss-Prot
    Q3UWA6
    Related
    ENSMUSP00000077236.7, ENSMUST00000078095.11
    Conserved Domains (4) summary
    smart00044
    Location:763 → 954
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:790 → 977
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl10011
    Location:35 → 415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21453
    Location:480 → 725
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136674282..136758740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UWA6.1 GenPept UniProtKB/Swiss-Prot:Q3UWA6

Gene LinkOut

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