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Trip12 thyroid hormone receptor interactor 12 [ Mus musculus (house mouse) ]

Gene ID: 14897, updated on 21-Apr-2024

Summary

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Official Symbol
Trip12provided by MGI
Official Full Name
thyroid hormone receptor interactor 12provided by MGI
Primary source
MGI:MGI:1309481
See related
Ensembl:ENSMUSG00000026219 AllianceGenome:MGI:1309481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtl6; TRIP-12; 1110036I07Rik; 6720416K24Rik
Summary
Predicted to enable thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Involved in regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 27.8), placenta adult (RPKM 25.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C5; 1 43.42 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (84698910..84818285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (84721189..84850004, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene STARR-seq mESC enhancer starr_01515 Neighboring gene predicted gene, 57795 Neighboring gene microRNA 5126 Neighboring gene predicted gene, 51637 Neighboring gene STARR-seq mESC enhancer starr_01519 Neighboring gene STARR-seq mESC enhancer starr_01525 Neighboring gene F-box protein 36 Neighboring gene STARR-seq mESC enhancer starr_01531 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 14 Neighboring gene predicted gene, 39669 Neighboring gene predicted pseudogene 15433

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Chen D, et al. Mol Cell, 2013 Jul 11. PMID 23747016, Free PMC Article
  2. Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells. An CI, et al. Skelet Muscle, 2013 May 10. PMID 23663701, Free PMC Article
  3. The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. Kajiro M, et al. PLoS One, 2011. PMID 22028794, Free PMC Article
  4. Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation. Tang Y, et al. Free Radic Biol Med, 2020 Dec. PMID 33080340
  5. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Chio II, et al. Nat Cell Biol, 2012 May 6. PMID 22561347

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of TGFbeta signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12.
    Title: Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12.
  2. Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
    Title: Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
  3. data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
    Title: TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
  4. Trip12 is involved in global gene expression and plays an important role in mouse development.
    Title: The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31615

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin boundary formation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIP12
Names
HECT-type E3 ubiquitin transferase TRIP12
TR-interacting protein 12
gene trap locus 6
thyroid receptor interactor TRIP12
thyroid receptor-interacting protein 12
NP_598736.4
XP_006496472.1
XP_006496477.1
XP_006496479.1
XP_006496485.1
XP_006496490.1
XP_006496492.1
XP_011236956.1
XP_011236957.1
XP_011236959.1
XP_011236960.1
XP_011236961.1
XP_011236963.1
XP_011236964.1
XP_011236965.1
XP_011236966.1
XP_011236968.1
XP_011236969.1
XP_011236970.1
XP_011236971.1
XP_011236972.1
XP_011236975.1
XP_017172116.1
XP_017172162.1
XP_030104755.1
XP_030104782.1
XP_030104802.1
XP_030104858.1
XP_030104872.1
XP_030104920.1
XP_030105028.1
XP_030105040.1
XP_030105055.1
XP_030105107.1
XP_030105119.1
XP_030105145.1
XP_030105170.1
XP_030105185.1
XP_036016722.1
XP_036016773.1
XP_036016798.1
XP_036016802.1
XP_036016854.1
XP_036016870.1
XP_036016899.1
XP_036017009.1
XP_036017145.1
XP_036017160.1
XP_036017182.1
XP_036017235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133975.4 → NP_598736.4  E3 ubiquitin-protein ligase TRIP12

    See identical proteins and their annotated locations for NP_598736.4

    Status: VALIDATED

    Source sequence(s)
    AC123882, AK158807, AW543112, BG695625, CA319321, CF747879, CN536706, DV647354
    Consensus CDS
    CCDS35633.1
    UniProtKB/Swiss-Prot
    G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
    UniProtKB/TrEMBL
    A0A087WNZ7
    Related
    ENSMUSP00000027421.7, ENSMUST00000027421.13
    Conserved Domains (3) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1623 → 2023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    84698910..84818285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238658.4 → XP_011236960.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_011236960.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  2. XM_011238673.4 → XP_011236975.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1627 → 2027
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 832
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  3. XM_036160961.1 → XP_036016854.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:461 → 686
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1644 → 2044
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:786 → 848
    WWE; WWE domain

  4. XM_011238669.4 → XP_011236971.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

    See identical proteins and their annotated locations for XP_011236971.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1630 → 2030
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:770 → 835
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  5. XM_011238655.4 → XP_011236957.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_011236957.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  6. XM_030249180.2 → XP_030105040.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1627 → 2027
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 832
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  7. XM_030249310.2 → XP_030105170.1  E3 ubiquitin-protein ligase TRIP12 isoform X30

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:418 → 643
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1598 → 1998
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:738 → 803
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  8. XM_030249285.2 → XP_030105145.1  E3 ubiquitin-protein ligase TRIP12 isoform X29

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:418 → 643
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1601 → 2001
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:741 → 806
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  9. XM_030249325.2 → XP_030105185.1  E3 ubiquitin-protein ligase TRIP12 isoform X33

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1591 → 1991
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 804
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  10. XM_006496429.3 → XP_006496492.1  E3 ubiquitin-protein ligase TRIP12 isoform X31

    UniProtKB/TrEMBL
    A0A087WNZ7
    Related
    ENSMUSP00000139563.2, ENSMUST00000186648.7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1596 → 1996
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 804
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  11. XM_006496427.4 → XP_006496490.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

    See identical proteins and their annotated locations for XP_006496490.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1626 → 2026
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 831
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  12. XM_030249168.2 → XP_030105028.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1627 → 2027
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 832
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  13. XM_011238668.4 → XP_011236970.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

    See identical proteins and their annotated locations for XP_011236970.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1630 → 2030
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:770 → 835
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  14. XM_036160829.1 → XP_036016722.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  15. XM_006496416.5 → XP_006496479.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1665 → 2065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:811 → 872
    WWE; WWE domain

  16. XM_030249247.2 → XP_030105107.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1618 → 2018
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain

  17. XM_036161342.1 → XP_036017235.1  E3 ubiquitin-protein ligase TRIP12 isoform X32

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:418 → 643
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1594 → 1994
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:740 → 801
    WWE; WWE domain

  18. XM_030248998.2 → XP_030104858.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1641 → 2041
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 846
    WWE; WWE domain

  19. XM_006496414.5 → XP_006496477.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1668 → 2068
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 873
    WWE; WWE domain

  20. XM_030248922.2 → XP_030104782.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1661 → 2061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 874
    WWE; WWE domain

  21. XM_030248895.2 → XP_030104755.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1666 → 2066
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 874
    WWE; WWE domain

  22. XM_006496409.5 → XP_006496472.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1669 → 2069
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 874
    WWE; WWE domain

  23. XM_011238666.4 → XP_011236968.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1644 → 2044
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:812 → 849
    WWE; WWE domain

  24. XM_036160909.1 → XP_036016802.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1663 → 2063
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 875
    WWE; WWE domain

  25. XM_036160880.1 → XP_036016773.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1668 → 2068
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 875
    WWE; WWE domain

  26. XM_011238661.4 → XP_011236963.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1671 → 2071
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:812 → 876
    WWE; WWE domain

  27. XM_011238664.4 → XP_011236966.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1664 → 2064
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:812 → 877
    WWE; WWE domain

  28. XM_011238663.4 → XP_011236965.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1667 → 2067
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:812 → 877
    WWE; WWE domain

  29. XM_011238662.4 → XP_011236964.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1669 → 2069
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:812 → 877
    WWE; WWE domain

  30. XM_011238654.4 → XP_011236956.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_011236956.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  31. XM_006496422.5 → XP_006496485.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1638 → 2038
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 846
    WWE; WWE domain

  32. XM_030248942.2 → XP_030104802.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1660 → 2060
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 873
    WWE; WWE domain

  33. XM_030249012.2 → XP_030104872.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1639 → 2039
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:809 → 847
    WWE; WWE domain

  34. XM_036161267.1 → XP_036017160.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

    UniProtKB/Swiss-Prot
    G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1623 → 2023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain

  35. XM_030249259.2 → XP_030105119.1  E3 ubiquitin-protein ligase TRIP12 isoform X28

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:432 → 657
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1611 → 2011
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:752 → 816
    WWE; WWE domain

  36. XM_030249060.2 → XP_030104920.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:460 → 685
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1631 → 2031
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:780 → 844
    WWE; WWE domain

  37. XM_036161116.1 → XP_036017009.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:460 → 685
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1636 → 2036
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:782 → 843
    WWE; WWE domain

  38. XM_011238667.4 → XP_011236969.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:460 → 685
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1643 → 2043
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:785 → 847
    WWE; WWE domain

  39. XM_017316673.3 → XP_017172162.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:461 → 686
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1637 → 2037
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:781 → 845
    WWE; WWE domain

  40. XM_017316627.3 → XP_017172116.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:461 → 686
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1644 → 2044
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:786 → 848
    WWE; WWE domain

  41. XM_011238659.3 → XP_011236961.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_011236961.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  42. XM_036160977.1 → XP_036016870.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:461 → 686
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1644 → 2044
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:786 → 848
    WWE; WWE domain

  43. XM_036161006.1 → XP_036016899.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:460 → 685
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1643 → 2043
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:785 → 847
    WWE; WWE domain

  44. XM_011238657.4 → XP_011236959.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_011236959.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1672 → 2072
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:814 → 876
    WWE; WWE domain

  45. XM_011238670.4 → XP_011236972.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

    See identical proteins and their annotated locations for XP_011236972.1

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1630 → 2030
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:770 → 835
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  46. XM_030249195.2 → XP_030105055.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1627 → 2027
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 832
    WWE; WWE domain
    pfam07263
    Location:12 → 165
    DMP1; Dentin matrix protein 1 (DMP1)

  47. XM_036161252.1 → XP_036017145.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

    UniProtKB/Swiss-Prot
    G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1623 → 2023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain

  48. XM_036160905.1 → XP_036016798.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1665 → 2065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:811 → 872
    WWE; WWE domain

  49. XM_036161289.1 → XP_036017182.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

    UniProtKB/TrEMBL
    A0A087WNZ7
    Conserved Domains (3) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1618 → 2018
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E870.1 GenPept UniProtKB/Swiss-Prot:G5E870

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